Results 21 to 30 of about 14,134 (199)

Extracellular loops of BtuB facilitate transport of vitamin B12 through the outer membrane of E. coli.

PLoS Computational Biology, 2020
Vitamin B12 (or cobalamin) is an enzymatic cofactor essential both for mammals and bacteria. However, cobalamin can be synthesized only by few microorganisms so most bacteria need to take it up from the environment through the TonB-dependent transport ...
Tomasz Pieńko, Joanna Trylska
doaj   +1 more source

Serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or other acute enteropathies

Journal of Veterinary Internal Medicine, 2023
Background Low serum cobalamin concentrations have been associated with ileal malabsorption in dogs with chronic enteropathy. Increased serum methylmalonic acid (MMA) concentrations indicate cobalamin deficiency on a cellular level.
Michael Hung, Justin Heinz, Jӧrg M. Steiner, Jan Suchodolski, Jonathan Lidbury   +4 more
doaj   +1 more source

Vitamin B12 in Cats: Nutrition, Metabolism, and Disease

Animals, 2023
Cobalamin is a water-soluble molecule that has an important role in cellular metabolism, especially in DNA synthesis, methylation, and mitochondrial metabolism. Cobalamin is bound by intrinsic factor (IF) and absorbed in the ileal tract.
Gerardo Siani, Beatrice Mercaldo, Maria Chiara Alterisio, Antonio Di Loria   +3 more
doaj   +1 more source

In Dogs With Chronic Enteropathies, Can Oral B12 Tablets Be Used to Treat Hypocobalaminaemia?

Veterinary Evidence, 2019
PICO question In dogs with chronic enteropathy does treatment with oral cobalamin compared to parenteral cobalamin provide serum cobalamin levels greater than 270 ng/L?
Avril McGinn
doaj   +1 more source

Cobalamin Scarcity Modifies Carbon Allocation and Impairs DMSP Production Through Methionine Metabolism in the Haptophyte Microalgae Tisochrysis lutea

Frontiers in Marine Science, 2020
Cobalamin (vitamin B12) is a cobalt-containing enzymatic cofactor involved in methionine synthesis. Provided only by select bacteria and archaea in marine systems, this vitamin is known to limit primary production in different oceanic areas ...
Charlotte Nef, Céline Henry, Élodie Nicolau, Jean-Baptiste Bérard, Fabienne Hervé, Amandine M. N. Caruana, Raymond Kaas, Francis Mairet, Matthieu Garnier   +8 more
doaj   +1 more source

Effect of Administration Route on the Pharmacokinetics of Cobalamin in Elderly Patients: A Randomized Controlled Trial

Current Therapeutic Research, 2014
Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD, Eline M.V.J. Donders, MD, Sjoerd L. Verweij, PharmD, Ruud T.M. Van der Hoeven, PharmD, Kees J. Kalisvaart, MD, PhD   +4 more
doaj   +1 more source

Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 126-132, January/February 2023., 2023
Abstract Background After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato‐ and myelotoxic mycotoxins T‐2, HT‐2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were ...
Barbara Glanemann, Karen Humm, Mariana Abreu, Sophie Aspinall, David Buckeridge, Hope Carveth, Hannah Darcy, Jessica Florey, Polly Frowde, Isuru Gajanayake, Kate Green, Emma Holmes, Alenka Hrovat, Anne‐Katherine Jasensky, Bryn A Jones, Vasiliki Lantzaki, Eve JY Lo, Kirsty MacDonald, Kevin O'Brien, Alejandro Suárez‐Bonnet, Nele Van den Steen, Balazs Szladovits, Annelies Willems, Helen Wilson   +23 more
wiley   +1 more source

Identification and quantitation of cobalamin and cobalamin analogues in human feces [PDF]

The American Journal of Clinical Nutrition, 2008
Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined.We aimed to develop a liquid chromatography-mass spectrometry method for cobalamin and cobalamin analogues and to identify and quantitiate the amounts present in human ...
Robert H. Allen, Sally P. Stabler
openaire   +3 more sources

An investigation into an outbreak of pancytopenia in cats in the United Kingdom

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 117-125, January/February 2023., 2023
Abstract Background In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats.
Barbara Glanemann, Karen Humm, Camilla Pegram, Daniel L. Chan   +3 more
wiley   +1 more source

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

Nature Communications, 2023
Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for ...
Johnny Mendoza, Meredith Purchal, Kazuhiro Yamada, Markos Koutmos   +3 more
doaj   +1 more source