Results 21 to 30 of about 51,500 (320)

The cobalamin-binding protein in zebrafish is an intermediate between the three cobalamin-binding proteins in human.

PLoS ONE, 2012
In humans, three soluble extracellular cobalamin-binding proteins; transcobalamin (TC), intrinsic factor (IF), and haptocorrin (HC), are involved in the uptake and transport of cobalamin.
Eva Greibe, Sergey Fedosov, Ebba Nexo
doaj   +1 more source

Crystal structure of an atypical cobalamin riboswitch reveals RNA structural adaptability as basis for promiscuous ligand binding

Nucleic Acids Research, 2020
Cobalamin riboswitches encompass a structurally diverse group of cis-acting, gene regulatory elements found mostly in bacterial messenger RNA and are classified into subtypes based on secondary and tertiary characteristics.
Clarence W Chan, A. Mondragón
semanticscholar   +1 more source

Gene identification for the cblD defect of vitamin B12 metabolism [PDF]

, 2008
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the ...
Baumgartner, M R, Coelho, D, Fowler, B, Lerner-Ellis, J P, Newbold, R F, Rosenblatt, D S, Stucki, M, Suormala, T   +7 more
core   +1 more source

In Dogs With Chronic Enteropathies, Can Oral B12 Tablets Be Used to Treat Hypocobalaminaemia?

Veterinary Evidence, 2019
PICO question In dogs with chronic enteropathy does treatment with oral cobalamin compared to parenteral cobalamin provide serum cobalamin levels greater than 270 ng/L?
Avril McGinn
doaj   +1 more source

Cobalamin Scarcity Modifies Carbon Allocation and Impairs DMSP Production Through Methionine Metabolism in the Haptophyte Microalgae Tisochrysis lutea

Frontiers in Marine Science, 2020
Cobalamin (vitamin B12) is a cobalt-containing enzymatic cofactor involved in methionine synthesis. Provided only by select bacteria and archaea in marine systems, this vitamin is known to limit primary production in different oceanic areas ...
Charlotte Nef, Céline Henry, Élodie Nicolau, Jean-Baptiste Bérard, Fabienne Hervé, Amandine M. N. Caruana, Raymond Kaas, Francis Mairet, Matthieu Garnier   +8 more
doaj   +1 more source

De Novo Cobalamin Biosynthesis, Transport, and Assimilation and Cobalamin-Mediated Regulation of Methionine Biosynthesis in Mycobacterium smegmatis

Journal of Bacteriology, 2020
Alterations in cobalamin-dependent metabolism have marked the evolution of Mycobacterium tuberculosis into a human pathogen. However, the role(s) of cobalamin in mycobacterial physiology remain poorly understood.
Terry Kipkorir, Gabriel T M Mashabela, Timothy J. De Wet, A. Koch, L. Wiesner, V. Mizrahi, D. Warner   +6 more
semanticscholar   +1 more source

Is Cobalt Joining the σ‑/π-Hole Crown? Exploring Noncovalent Interactions in Cobalamin. [PDF]

JACS Au
Burguera S, Bauzá A.
europepmc   +2 more sources

Utilization of Cobalamin Is Ubiquitous in Early-Branching Fungal Phyla

bioRxiv, 2020
Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of life.
M. Orłowska, Kamil Steczkiewicz, A. Muszewska   +2 more
semanticscholar   +1 more source

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme. [PDF]

, 2019
Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Mok, Kenny, Park, Jong, Quanstrom, Kathryn, Sokolovskaya, Olga, Taga, Michi, Tran, Jennifer   +5 more
core   +1 more source

Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutase

bioRxiv, 2020
Cobalamin, commonly known as vitamin B12, is an essential micronutrient for humans because of its role as an enzyme cofactor. Cobalamin is one of over a dozen structurally related compounds – cobamides – that are found in food and are produced by ...
O. Sokolovskaya, Tanja Plessl, H. Bailey, S. Mackinnon, M. Baumgartner, W. Yue, D. Froese, M. Taga   +7 more
semanticscholar   +1 more source