Results 31 to 40 of about 39,443 (213)

Decreased cobalamin sensitivity and biological aging acceleration in the general population

The Journal of Nutrition, Health and Aging
Background: The evidence on the association between cobalamin (Cbl) and aging or relevant outcomes is limited and controversial. We aimed to investigate the relationships between cobalamin intake- and function-related biomarkers and biological aging ...
Fan Tang, Hongbin Qiu, Yan Liu, Junchen Guo, Zheming Huang, Shaohong Fang, Yiying Zhang, Shanjie Wang   +7 more
doaj   +1 more source

Prevalence of serum cobalamin and folate deficiency among children aged 6–59 months: A hospital-based cross-sectional study from Northern India

Journal of Family Medicine and Primary Care, 2022
Context: Cobalamin and folate are essential for the synthesis of nucleic acids and in the maintenance of myelin. They are required during the period of the rapid growth of infancy and childhood.
Surbhi Gupta, Partha Haldar, Archana Singh, Sumit Malhotra, Shashi Kant   +4 more
doaj   +1 more source

Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report

BMC Pediatrics, 2021
Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch, Daniela Gašperíková   +6 more
doaj   +1 more source

Transcriptomic and proteomic changes associated with cobalamin-dependent propionate production by the rumen bacterium Xylanibacter ruminicola

mSystems
Xylanibacter ruminicola is an abundant rumen bacterium that produces propionate in a cobalamin (vitamin B12)-dependent manner via the succinate pathway.
Sam C. Mahoney-Kurpe, Nikola Palevich, Dragana Gagic, Patrick J. Biggs, Peter M. Reid, Ianina Altshuler, Phillip B. Pope, Graeme T. Attwood, Christina D. Moon   +8 more
doaj   +1 more source

Fat digestibility is reduced in old cats with subnormal cobalamin concentrations

Journal of Nutritional Science, 2014
Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility.
Anna Salas, Carmen-Loreto Manuelian, Marta Garganté, Núria Sanchez, Sonia Fernández, Marco Compagnucci, Jose Joaquín Cerón, Isabelle Jeusette, Lluís Vilaseca, Celina Torre   +9 more
doaj   +1 more source

Cobalamin deficiency resulting in a rare haematological disorder: a case report

Journal of Medical Case Reports, 2009
Introduction We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. Case presentation A 52-year-old man from the Democratic Republic of Congo
Chapuis Thomas M, Favrat Bernard, Bodenmann Patrick   +2 more
doaj   +1 more source

Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups

Nutrition Journal, 2020
Background Older people are reported to be prone to imbalances between cobalamin and folate status with possible adverse effects on health. This longitudinal study investigates dynamics and interactions of cobalamin and folate status in a cohort of ...
Alexandra Jungert, Carola Zenke-Philippi, Monika Neuhäuser-Berthold   +2 more
doaj   +1 more source

Alterations in serum amino acid concentrations in dogs with protein-losing enteropathy [PDF]

, 2018
BackgroundCertain amino acids are decreased in humans with inflammatory bowel disease (IBD) and supplementation with the same amino acids has shown beneficial effects in animal models of IBD.
Allenspach, Beeken, Bettenworth, Clayton, Coburn, Dąbrowski, Gupta, Hashimoto, Hou, Kim, Kim, Li, Liu, Liu, Middleton, Morgan, Nikolaus, Ren, Richard, Ruth, Schrocksnadel, Tsune, Walser, Wang, Widner, Xin   +25 more
core   +4 more sources

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) [PDF]

, 2013
It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes.
Biedendieck, Rebekka, Deery, Evelyne, Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Moore, Simon J., Rigby, Stephen E. J., Warren, Martin J.   +7 more
core   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source