Results 31 to 40 of about 14,134 (199)

Cobalamin deficiency resulting in a rare haematological disorder: a case report

Journal of Medical Case Reports, 2009
Introduction We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. Case presentation A 52-year-old man from the Democratic Republic of Congo
Chapuis Thomas M, Favrat Bernard, Bodenmann Patrick   +2 more
doaj   +1 more source

Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report

BMC Pediatrics, 2021
Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch, Daniela Gašperíková   +6 more
doaj   +1 more source

Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats. [PDF]

Journal of Clinical Investigation, 1991
To determine which parts of the cobalamin (cbl) molecule are required for enzyme activity and which parts, if altered, might inhibit cbl-dependent enzyme activity, we synthesized 16 cbl analogues and administered them to nutritionally normal rats. The cbl analogues, with either modifications of the propionamide side chains of the A-, B-, and C-rings ...
Sally P. Stabler, Eric P. Brass, Robert H. Allen, Paul D. Marcell   +3 more
openaire   +3 more sources

Enhanced cobalamin biosynthesis in Ensifer adhaerens by regulation of key genes with gradient promoters

Synthetic and Systems Biotechnology, 2022
Cobalamin is an essential human vitamin widely used in the pharmaceutical, food, and feed additive industries and currently produced by bacteria or archaea. Ensifer adhaerens HY-1 is an industrial strain that also produces cobalamin.
Sha Xu, Zhiqiang Xiao, Shiqin Yu, Weizhu Zeng, Yongming Zhu, Jingwen Zhou   +5 more
doaj  

Fat digestibility is reduced in old cats with subnormal cobalamin concentrations

Journal of Nutritional Science, 2014
Fat digestibility is decreased in old cats for unknown reasons. Subclinical gastrointestinal diseases and pancreatic dysfunction, both related to ageing, can affect food digestibility.
Anna Salas, Carmen-Loreto Manuelian, Marta Garganté, Núria Sanchez, Sonia Fernández, Marco Compagnucci, Jose Joaquín Cerón, Isabelle Jeusette, Lluís Vilaseca, Celina Torre   +9 more
doaj   +1 more source

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

EFSA Journal, 2015
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12).
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)
doaj   +1 more source

Sinorhizobium meliloti Requires a Cobalamin-Dependent Ribonucleotide Reductase for Symbiosis With Its Plant Host

Molecular Plant-Microbe Interactions, 2010
Vitamin B12 (cobalamin) is a critical cofactor for animals and protists, yet its biosynthesis is limited to prokaryotes. We previously showed that the symbiotic nitrogen-fixing alphaproteobacterium Sinorhizobium meliloti requires cobalamin to establish a
Michiko E. Taga, Graham C. Walker
doaj   +1 more source

Prevalence of serum cobalamin and folate deficiency among children aged 6–59 months: A hospital-based cross-sectional study from Northern India

Journal of Family Medicine and Primary Care, 2022
Context: Cobalamin and folate are essential for the synthesis of nucleic acids and in the maintenance of myelin. They are required during the period of the rapid growth of infancy and childhood.
Surbhi Gupta, Partha Haldar, Archana Singh, Sumit Malhotra, Shashi Kant   +4 more
doaj   +1 more source

Dynamics and interactions of cobalamin and folate status during advanced aging – a longitudinal study in a community-dwelling cohort with multiple follow-ups

Nutrition Journal, 2020
Background Older people are reported to be prone to imbalances between cobalamin and folate status with possible adverse effects on health. This longitudinal study investigates dynamics and interactions of cobalamin and folate status in a cohort of ...
Alexandra Jungert, Carola Zenke-Philippi, Monika Neuhäuser-Berthold   +2 more
doaj   +1 more source

Cobalamin and folate status in 6 to 35 months old children presenting with acute diarrhea in Bhaktapur, Nepal.

PLoS ONE, 2014
BackgroundCobalamin and folate are essential micronutrients and are important in DNA and RNA synthesis, cell proliferation, growth, hematopoiesis, and cognitive function.
Manjeswori Ulak, Ram K Chandyo, Ramesh K Adhikari, Pushpa R Sharma, Halvor Sommerfelt, Helga Refsum, Tor A Strand   +6 more
doaj   +1 more source