Results 41 to 50 of about 33,619 (290)

Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) [PDF]

, 2013
It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes.
Biedendieck, Rebekka, Deery, Evelyne, Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Moore, Simon J., Rigby, Stephen E. J., Warren, Martin J.   +7 more
core   +1 more source

An investigation into an outbreak of pancytopenia in cats in the United Kingdom

Journal of Veterinary Internal Medicine, Volume 37, Issue 1, Page 117-125, January/February 2023., 2023
Abstract Background In spring 2021 increasing numbers of cats presenting with severe pancytopenia were noted in United Kingdom (UK). Objective To describe process and outcome of the investigation performed into the outbreak of pancytopenia in cats.
Barbara Glanemann, Karen Humm, Camilla Pegram, Daniel L. Chan   +3 more
wiley   +1 more source

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo

Nature Communications, 2023
Cobalamin-dependent methionine synthase (MS) is a key enzyme in methionine and folate one-carbon metabolism. MS is a large multi-domain protein capable of binding and activating three substrates: homocysteine, folate, and S-adenosylmethionine for ...
Johnny Mendoza, Meredith Purchal, Kazuhiro Yamada, Markos Koutmos   +3 more
doaj   +1 more source

Whole-Blood Taurine Concentrations in Cats With Intestinal Disease [PDF]

, 2017
BackgroundIncreased delivery of taurine-conjugated bile acids to the distal bowel can lead to dysbiosis resulting in colitis in mouse models of inflammatory bowel disease.
Awwad, Backus, Backus, Devkota, Duboc, Heinze, Hickman, Hickman, Huxtable, Jacobs, Jergens, Kim, Laflamme, NRC, Rau, Schuller-Levis, Schuller-Levis, Stratton-Phelps, Sugano, Testa, Theisen, Vrieze, Zhang   +22 more
core   +3 more sources

14C-Cobalamin Absorption from Endogenously Labeled Chicken Eggs Assessed in Humans Using Accelerator Mass Spectrometry. [PDF]

, 2019
Traditionally, the bioavailability of vitamin B-12 (B12) from in vivo labeled foods was determined by labeling the vitamin with radiocobalt (57Co, 58Co or 60Co).
Allen, Lindsay H, Buchholz, Bruce A, Calvert, Christopher C, Garrod, Marjorie G, Green, Ralph, Miller, Joshua W, Rossow, Heidi A   +6 more
core   +2 more sources

Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats. [PDF]

Journal of Clinical Investigation, 1991
To determine which parts of the cobalamin (cbl) molecule are required for enzyme activity and which parts, if altered, might inhibit cbl-dependent enzyme activity, we synthesized 16 cbl analogues and administered them to nutritionally normal rats. The cbl analogues, with either modifications of the propionamide side chains of the A-, B-, and C-rings ...
Sally P. Stabler, Eric P. Brass, Robert H. Allen, Paul D. Marcell   +3 more
openaire   +3 more sources

Enhanced cobalamin biosynthesis in Ensifer adhaerens by regulation of key genes with gradient promoters

Synthetic and Systems Biotechnology, 2022
Cobalamin is an essential human vitamin widely used in the pharmaceutical, food, and feed additive industries and currently produced by bacteria or archaea. Ensifer adhaerens HY-1 is an industrial strain that also produces cobalamin.
Sha Xu, Zhiqiang Xiao, Shiqin Yu, Weizhu Zeng, Yongming Zhu, Jingwen Zhou   +5 more
doaj  

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

EFSA Journal, 2015
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12).
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)
doaj   +1 more source

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) [PDF]

, 2014
Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt
Alan Scott, Andrew D. Lawrence, Banerjee, Blanche, Cheng, Cheung, Christopher M. Johnson, Dalhus, Daragan, Debussche, Delaglio, Delaglio, Emsley, Evans, Fogh, Fonseca, Johnson, Kim, Lawrence, Leslie, Lexa, Mark J. Howard, Martin J. Warren, Mera, Michael A. Geeves, Michelle L. Rowe, Monera, Murshudov, Pace, Parsons, Piotto, Rashid, Richard W. Pickersgill, Samantha L. Taylor, Sampson, States, Stephen E. J. Rigby, Stich, Stich, Vagin, van den Heuvel, Vranken, Warren, Webb, Wishart, Wittung-Stafshede   +45 more
core   +3 more sources

Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report

BMC Pediatrics, 2021
Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch, Daniela Gašperíková   +6 more
doaj   +1 more source