Results 41 to 50 of about 14,134 (199)

Relationship between serum cobalamin concentration and endoscopic ileal appearance and histology in dogs with chronic inflammatory enteropathy

open access: yesJournal of Veterinary Internal Medicine, 2022
Background It has not been determined whether ileal appearance differs among dogs with chronic inflammatory enteropathy (CIE) and different serum concentrations of cobalamin.
Eva M. Pérez‐Merino   +5 more
doaj   +1 more source

Cost‐Effectiveness of Ferritin Screening Thresholds for Iron Deficiency in Reproductive‐Age Women

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Iron deficiency (ID) is a top five leading cause of disability‐adjusted life‐years in women of reproductive age around the world. Despite its enormous health burden, no screening guidelines exist for the detection and treatment of ID in women of reproductive age.
Daniel Wang   +7 more
wiley   +1 more source

Phenotypical Characterization of Gastroenterological and Metabolic Manifestations in Patients With Williams–Beuren Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gastrointestinal (GI) symptoms are common in patients with Williams–Beuren syndrome (WBS), but their prevalence and possible causes are not yet fully known. This study assessed GI symptoms' prevalence and their possible origin by performing a predefined set of tests in adult WBS patients.
Maria Francesca Bedeschi   +10 more
wiley   +1 more source

The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus

open access: yesScientific Reports, 2021
Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This study aimed to determine whether or not metformin is a risk factor for DPN.
Manal Mohammed Hashem   +3 more
doaj   +1 more source

Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults

open access: yesAnnals of Neurology, EarlyView.
At low levels of B12, specifically when bound to transcobalamin for cellular uptake, evidence of slower conductivity in the brain could point toward impaired myelin. At high levels of B12, specifically when bound to the biologically inert transport protein haptocorrin, biomarkers of neurodegeneration appear in the serum, indicating neuroaxonal injury ...
Alexandra Beaudry‐Richard   +22 more
wiley   +1 more source

A dodecylamine derivative of cyanocobalamin potently inhibits the activities of cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase of Caenorhabditis elegans

open access: yesFEBS Open Bio, 2014
In this study, we showed that cyanocobalamin dodecylamine, a ribose 5′-carbamate derivative of cyanocobalamin, was absorbed and accumulated to significant levels by Caenorhabditis elegans and was not further metabolized.
Tomohiro Bito   +4 more
doaj   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

open access: yesChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source

Serial Measurement of Serum Pancreatic Lipase Immunoreactivity, Feline Trypsin-like Immunoreactivity, and Cobalamin Concentrations in Kittens

open access: yesVeterinary Sciences, 2022
Serum concentrations of feline pancreatic lipase immunoreactivity (fPLI), feline trypsin-like immunoreactivity (fTLI), and cobalamin are commonly used for the diagnostic investigation of cats with gastrointestinal signs.
Evangelia M. Stavroulaki   +5 more
doaj   +1 more source

Cobalamin coenzyme forms are not likely to be superior to cyano‐ and hydroxyl‐cobalamin in prevention or treatment of cobalamin deficiency [PDF]

open access: yesMolecular Nutrition & Food Research, 2015
Methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) are coenzymes for methionine synthase and methylmalonyl‐CoA mutase, respectively. Hydroxylcobalamin (HOCbl) and cyanocobalamin (CNCbl) are frequently used for supplementation. MeCbl and AdoCbl have recently emerged as alternative forms in supplements. In the light of metabolic transformation of Cbl
Rima Obeid   +3 more
openaire   +4 more sources

Recent Advances in Heterogenization of Photocatalysts on Polymer Supports and Applications in Organic Synthesis

open access: yesChemPhotoChem, EarlyView.
This review focuses on recent developments in heterogenization of photocatalysts into polymers, highlighting methods like photocatalyst polymerization, post‐grafting, and 3D printing. Discussion about these different approaches of heterogeneous photocatalysis (advantages and drawbacks) is provided.
Cloé Delacourt   +3 more
wiley   +1 more source

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