Results 41 to 50 of about 43,643 (334)

Metagenomic and chemical characterization of soil cobalamin production

The ISME Journal, 2019
Cobalamin (vitamin B12) is an essential enzyme cofactor for most branches of life. Despite the potential importance of this cofactor for soil microbial communities, the producers and consumers of cobalamin in terrestrial environments are still unknown ...
Xinda Lu, K. Heal, A. Ingalls, A. Doxey, J. Neufeld   +4 more
semanticscholar   +1 more source

An on-line solid phase extraction procedure for the routine quantification of urinary methylmalonic acid by liquid chromatography-tandem mass spectrometry [PDF]

, 2010
Background: The goal of this study was to develop and to validate an improved isotope-dilution-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of methylmalonic acid (MMA) in urine.
Bolann BJ, Klee GG, Kushnir MM, Magera M, Rasmussen K   +4 more
core   +1 more source

To B12 or not to B12: Five questions on the role of cobalamin in host-microbial interactions

PLoS Pathogens, 2019
Vitamins are organic compounds that are essential to the health of an organism. Humans cannot synthesize vitamins but obtain vitamins through dietary intake.
Carol A. Rowley, M. M. Kendall
semanticscholar   +1 more source

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme. [PDF]

, 2019
Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Mok, Kenny, Park, Jong, Quanstrom, Kathryn, Sokolovskaya, Olga, Taga, Michi, Tran, Jennifer   +5 more
core   +1 more source

Retroconversion of estrogens into androgens by bacteria via a cobalamin-mediated methylation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Steroids are mainly produced by animals, while bacteria are major steroid consumers in the biosphere. Anaerobic environments are major reservoirs for estrogens; however, prior to this study, biochemical mechanisms involved in anaerobic ...
Pong Wang, Yi-Lung Chen, S. Wei, Kan Wu, Tzong-Huei Lee, Tien-Yu Wu, Yin-Ru Chiang   +6 more
semanticscholar   +1 more source

Identification and quantitation of cobalamin and cobalamin analogues in human feces [PDF]

The American Journal of Clinical Nutrition, 2008
Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the amounts present have not been determined.We aimed to develop a liquid chromatography-mass spectrometry method for cobalamin and cobalamin analogues and to identify and quantitiate the amounts present in human ...
Robert H. Allen, Sally P. Stabler
openaire   +3 more sources

Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency

Journal of Inherited Metabolic Disease, 2016
BackgroundRemethylation defects are rare inherited disorders in which impaired remethylation of homocysteine to methionine leads to accumulation of homocysteine and perturbation of numerous methylation reactions.ObjectiveTo summarise clinical and ...
M. Huemer, D. Diodato, B. Schwahn, M. Schiff, A. Bandeira, J. Benoist, A. Burlina, R. Cerone, M. Couce, Á. García-Cazorla, G. la Marca, E. Pasquini, L. Vilarinho, J. Weisfeld-Adams, V. Kožich, H. Blom, M. Baumgartner, C. Dionisi-Vici   +17 more
semanticscholar   +1 more source

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR) [PDF]

, 2014
Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt
Alan Scott, Andrew D. Lawrence, Banerjee, Blanche, Cheng, Cheung, Christopher M. Johnson, Dalhus, Daragan, Debussche, Delaglio, Delaglio, Emsley, Evans, Fogh, Fonseca, Johnson, Kim, Lawrence, Leslie, Lexa, Mark J. Howard, Martin J. Warren, Mera, Michael A. Geeves, Michelle L. Rowe, Monera, Murshudov, Pace, Parsons, Piotto, Rashid, Richard W. Pickersgill, Samantha L. Taylor, Sampson, States, Stephen E. J. Rigby, Stich, Stich, Vagin, van den Heuvel, Vranken, Warren, Webb, Wishart, Wittung-Stafshede   +45 more
core   +3 more sources

Cobalamin deficiency resulting in a rare haematological disorder: a case report

Journal of Medical Case Reports, 2009
Introduction We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. Case presentation A 52-year-old man from the Democratic Republic of Congo
Chapuis Thomas M, Favrat Bernard, Bodenmann Patrick   +2 more
doaj   +1 more source

Genetic testing is necessary for correct diagnosis and treatment in patients with isolated methylmalonic aciduria: a case report

BMC Pediatrics, 2021
Background Isolated methylmalonic aciduria can be caused by pathogenic mutations in the gene for methylmalonyl-CoA mutase or in the genes encoding enzymes involved in the intracellular metabolism of cobalamin.
Katarína Brennerová, Martina Škopková, Mária Ostrožlíková, Jana Šaligová, Juraj Staník, Vladimír Bzdúch, Daniela Gašperíková   +6 more
doaj   +1 more source