Results 101 to 110 of about 307,196 (303)

Increased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration [PDF]

, 2009
In humans, cocaine use has long been associated with poor attentional control and decreased efficiency in goal-oriented behavior. Animal models of these stereotypic drug effects, however, have thus far failed to produce quantifiable data sets in part ...
Olsen, Adam
core  

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +3 more
core   +1 more source

An interdisciplinary review of the interplay of conflict, socio‐economic factors, and land cover and vegetation dynamics in Colombia

PLANTS, PEOPLE, PLANET, EarlyView.
Colombia's forests play a crucial role in preserving biodiversity and mitigating climate change, but they are currently facing severe degradation, particularly after the 2016 Peace Agreement. Our literature review highlights a growing research interest in this topic and demonstrates how interdisciplinary approaches combining diverse methods can enhance
Estefanía Muñoz, Jesús A. Anaya, Nicola Clerici, Lina M. Estupinan‐Suarez, Isabel Lopera, Solveig Richter, Alejandro Salazar, Carlos A. Sierra, Andrés Tangarife‐Escobar, Miguel D. Mahecha, David Montero, Pablo Palacios‐Rodríguez, Pablo Ramos, Santiago Botía   +13 more
wiley   +1 more source

Reduced frontal brain volume in non-treatment seeking cocaine dependent individuals: exploring the role of impulsivity, depression and smoking

Frontiers in Human Neuroscience, 2014
In cocaine-dependent patients, grey matter (GM) volume reductions have been observed in the frontal lobes that are associated with duration of cocaine use.
Cleo Lina Crunelle, Cleo Lina Crunelle, Anne Marije eKaag, Guido eVan Wingen, Hanna E. van den Munkhof, Judith eHomberg, Liesbeth eReneman, Wim eVan Den Brink, Wim eVan Den Brink   +8 more
doaj   +1 more source

Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD [PDF]

, 2016
Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD). Impulsivity is expressed as reduced response inhibition capacity, an executive control mechanism that prevents premature execution of an intermittently ...
Bardo, M. T., Dwoskin, L. P., Kantak, K. M., Somkuwar, S. S.   +3 more
core   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]

, 2017
Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A., Bohn, Austin T., Ebben, Amanda L., Gasser, Paul J., Jasek, Isabella A., Kurtoglu, Beliz, Lovell, Marissa E., Mantsch, John R., Wheeler, Daniel S., Wheeler, Robert A.   +9 more
core   +2 more sources

Development of a Novel Polyleucine‐Based Immunopotentiator for Subunit Vaccines Against Group A Streptococcus

Small, EarlyView.
Self‐assembling amphiphilic peptide L15K6 is used as a novel immunoadjuvant for the development of a Group A Streptococcus vaccine. Robust antigen‐specific IgG responses are generated and manage to kill isolated strains of Group A Streptococcus. Cellular and bulk RNA sequencing data reveals that L15K6 regulates immune responses potentially through TLR ...
Lantian Lu, Jazmina L. Gonzalez Cruz, Rabina Giri, Yuexiao Zhang, Sahra Bashiri, Leslie C. Domínguez Cadena, Shuhang Li, Zeinab G. Khalil, Waleed M. Hussein, Jingwen Wang, Jolynn Kiong, Xuehan Lu, Jiahui Zhang, Miao Lu, Wenbin Huang, Wei Yang Kong, Ummey Jannatun Nahar, Prashamsa Koirala, Zhong Guo, Patricia Walden, Antje Blumenthal, Jakob Begun, Kirill Alexandrov, Istvan Toth, Rachel J. Stephenson, Mariusz Skwarczynski   +25 more
wiley   +1 more source

From Tobacco to Ultraprocessed Food: How Industry Engineering Fuels the Epidemic of Preventable Disease

The Milbank Quarterly, EarlyView.
Policy Points Ultraprocessed foods (UPFs) are engineered to heighten reward and accelerate delivery of reinforcing ingredients, driving compulsive consumption and disrupting appetite regulation. This is a growing challenge for health policy. UPFs share key engineering strategies adopted from the tobacco industry, such as dose optimization and hedonic ...
ASHLEY N. GEARHARDT, KELLY D. BROWNELL, ALLAN M. BRANDT   +2 more
wiley   +1 more source

Preventive Strength of Dyadic Social Interaction against Reacquisition/Reexpression of Cocaine Conditioned Place Preference

Frontiers in Behavioral Neuroscience, 2017
The reorientation away from drugs of abuse and toward social interaction is a highly desirable but as yet elusive goal in the therapy of substance dependence. We could previously show that cocaine preferring Sprague-Dawley rats which engaged in only four
Tanja Bregolin, Barbara S. Pinheiro, Rana El Rawas, Gerald Zernig   +3 more
doaj   +1 more source