Results 11 to 20 of about 40,355 (156)

Estimating the incidence of cocaine use and mortality with music lyrics about cocaine

npj Digital Medicine, 2021
In the United States, cocaine use and mortality have surged in the past 5 years. Considering cocaine’s reputation as a fashionable social drug, the rise of cocaine mentions in popular music may provide a signal of epidemiological trends of cocaine use ...
Yulin Hswen, Amanda Zhang, John S. Brownstein   +2 more
doaj   +1 more source

Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder: A Phase I Randomized Clinical Trial

Frontiers in Psychiatry, 2021
Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT2CR agonist lorcaserin administered with cocaine in participants with
Sade E. Johns, Lori Keyser-Marcus, Antonio Abbate, Edward Boone, Benjamin Van Tassell, Benjamin Van Tassell, Kathryn A. Cunningham, Noelle C. Anastasio, Justin L. Poklis, Tatiana Ramey, F. Gerard Moeller, F. Gerard Moeller   +11 more
doaj   +1 more source

Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice

Pharmacology Research & Perspectives, 2022
The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice.
Mackenzie E. Turner, Hanna N. Wetzel, Dakota B. Zinani, Christopher A. Crutchfield, Andrew B. Norman   +4 more
doaj   +1 more source

Chronic inhibition of dopamine β-hydroxylase facilitates behavioral responses to cocaine in mice. [PDF]

PLoS ONE, 2012
The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown.
Meriem Gaval-Cruz, Larry Cameron Liles, Paul Michael Iuvone, David Weinshenker   +3 more
doaj   +1 more source

The Src-Kinase Fyn is Required for Cocaine-Associated Memory Through Regulation of Tau

Frontiers in Pharmacology, 2022
Drug-associated context-induced relapse of cocaine-seeking behaviour requires the retrieval of drug-associated memory. Studies exploring the underlying neurobiological mechanism of drug memory formation will likely contribute to the development of ...
Hongchun Li, Xinglong Zhou, Rong Chen, Yuzhou Xiao, Tao Zhou   +4 more
doaj   +1 more source

A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens

Frontiers in Neuroscience, 2020
Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying cocaine seeking and to screen medications to reduce seeking.
Bethany A. Stennett, Bethany A. Stennett, Lori A. Knackstedt, Lori A. Knackstedt   +3 more
doaj   +1 more source

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry, 2021
Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn2+) also binds to the DAT, but the in vivo relevance of this interaction is unknown.
Juan L. Gomez, Jordi Bonaventura, Jacqueline Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez, Sherry Lam, Meghan L. Carlton, Randall J. Ellis, Chloe J. Jordan, Guo-hua Bi, Oscar Solis, Marco Pignatelli, Michael J. Bannon, Zheng-Xiong Xi, Gianluigi Tanda, Michael Michaelides   +16 more
doaj   +1 more source

Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.

PLoS ONE, 2020
The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching ...
David F Havlicek, Jonathan B Rosenberg, Bishnu P De, Martin J Hicks, Dolan Sondhi, Stephen M Kaminsky, Ronald G Crystal   +6 more
doaj   +1 more source

Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. [PDF]

PLoS ONE, 2014
Cocaine exposure during gestation causes protracted neurobehavioral changes consistent with a compromised glutamatergic system. Although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects ...
Kalindi Bakshi, Raminder Parihar, Satindra K Goswami, Melissa Walsh, Eitan Friedman, Hoau-Yan Wang   +5 more
doaj   +1 more source

The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice. [PDF]

PLoS ONE, 2014
The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states of ...
Jonathan S Miller, Jeffrey L Barr, Lauren J Harper, Rachel L Poole, Thomas J Gould, Ellen M Unterwald   +5 more
doaj   +1 more source