Results 11 to 20 of about 307,196 (303)

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: Pharmacological and behavioral genetics evidence [PDF]

Frontiers in Behavioral Neuroscience, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Jonathan eHollander, Don ePham, Christie eFowler, Paul J Kenny   +3 more
doaj   +5 more sources

Rabies screen reveals GPe control of cocaine-triggered plasticity [PDF]

Nature, 2017
Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results.
Kevin T Beier, Paul Hoerbelt, Boris D Heifets   +2 more
exaly   +3 more sources

Estimating the incidence of cocaine use and mortality with music lyrics about cocaine

npj Digital Medicine, 2021
In the United States, cocaine use and mortality have surged in the past 5 years. Considering cocaine’s reputation as a fashionable social drug, the rise of cocaine mentions in popular music may provide a signal of epidemiological trends of cocaine use ...
Yulin Hswen, Amanda Zhang, John S. Brownstein   +2 more
doaj   +1 more source

Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder: A Phase I Randomized Clinical Trial

Frontiers in Psychiatry, 2021
Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT2C receptor (5-HT2CR) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT2CR agonist lorcaserin administered with cocaine in participants with
Sade E. Johns, Lori Keyser-Marcus, Antonio Abbate, Edward Boone, Benjamin Van Tassell, Benjamin Van Tassell, Kathryn A. Cunningham, Noelle C. Anastasio, Justin L. Poklis, Tatiana Ramey, F. Gerard Moeller, F. Gerard Moeller   +11 more
doaj   +1 more source

Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice

Pharmacology Research & Perspectives, 2022
The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice.
Mackenzie E. Turner, Hanna N. Wetzel, Dakota B. Zinani, Christopher A. Crutchfield, Andrew B. Norman   +4 more
doaj   +1 more source

Chronic inhibition of dopamine β-hydroxylase facilitates behavioral responses to cocaine in mice. [PDF]

PLoS ONE, 2012
The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown.
Meriem Gaval-Cruz, Larry Cameron Liles, Paul Michael Iuvone, David Weinshenker   +3 more
doaj   +1 more source

The Src-Kinase Fyn is Required for Cocaine-Associated Memory Through Regulation of Tau

Frontiers in Pharmacology, 2022
Drug-associated context-induced relapse of cocaine-seeking behaviour requires the retrieval of drug-associated memory. Studies exploring the underlying neurobiological mechanism of drug memory formation will likely contribute to the development of ...
Hongchun Li, Xinglong Zhou, Rong Chen, Yuzhou Xiao, Tao Zhou   +4 more
doaj   +1 more source

Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats

Brain Stimulation, 2022
Background: Cocaine addiction is a major public health problem. Despite decades of intense research, no effective treatments are available. Both preclinical and clinical studies strongly suggest that deep brain stimulation of the nucleus accumbens (NAcc)
Marsida Kallupi, Jenni Kononoff, Philippe A. Melas, Johanna S. Qvist, Giordano de Guglielmo, Eric R. Kandel, Olivier George   +6 more
doaj   +1 more source

A Rat Model of Cocaine-Alcohol Polysubstance Use Reveals Altered Cocaine Seeking and Glutamate Levels in the Nucleus Accumbens

Frontiers in Neuroscience, 2020
Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying cocaine seeking and to screen medications to reduce seeking.
Bethany A. Stennett, Bethany A. Stennett, Lori A. Knackstedt, Lori A. Knackstedt   +3 more
doaj   +1 more source

Mandatory Minimum Sentencing Policies and Cocaine Use in the U.S., 1985–2013 [PDF]

, 2018
Background: As of May 2017, the United States federal government renewed its prioritization for the enforcement of mandatory minimum sentences for illicit drug offenses.
Mezuk, Briana, Walker, Lauryn Saxe
core   +3 more sources