Results 21 to 30 of about 346,320 (307)
Frontiers in Neuroscience, 2020 Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying cocaine seeking and to screen medications to reduce seeking.
Bethany A. Stennett +3 more
doaj +1 more source
Mandatory Minimum Sentencing Policies and Cocaine Use in the U.S., 1985–2013 [PDF]
, 2018 Background: As of May 2017, the United States federal government renewed its prioritization for the enforcement of mandatory minimum sentences for illicit drug offenses.
Mezuk, Briana, Walker, Lauryn Saxe
core +3 more sources
Heliyon, 2023 A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measure ...
Dakota B. Zinani +2 more
doaj +1 more source
mGluR5 knockout mice exhibit normal conditioned place-preference to cocaine [PDF]
, 2011 Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine.
Andrew L. Varnell +2 more
core +2 more sources
Cocaine vaccine dAd5GNE protects against moderate daily and high-dose "binge" cocaine use.
PLoS ONE, 2020 The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching ...
David F Havlicek +6 more
doaj +1 more source
Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]
, 2012 This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J. +6 more
core +2 more sources
Addiction Neuroscience, 2023 Drug associated cues are a common relapse trigger for individuals recovering from cocaine use disorder. Sex and ovarian hormones influence patterns of cocaine use and relapse vulnerability, with studies indicating that females show increased cue-induced ...
Claire M. Corbett +2 more
doaj +1 more source
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
core +2 more sources
Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. [PDF]
PLoS ONE, 2014 Cocaine exposure during gestation causes protracted neurobehavioral changes consistent with a compromised glutamatergic system. Although cocaine profoundly disrupts glutamatergic neurotransmission and in utero cocaine exposure negatively affects ...
Kalindi Bakshi +5 more
doaj +1 more source
Toxicology Reports, 2019 Crack cocaine smokers inhale, alongside with cocaine, its pyrolysis product, anhydroecgonine methyl ester (AEME). We have previously described AEME neurotoxic effect and its additive effect when co-incubated with cocaine.
Raphael Caio Tamborelli Garcia +6 more
doaj +1 more source