Results 81 to 90 of about 346,320 (307)

Adolescent D-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood [PDF]

, 2016
RATIONALE: Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Lemay, Carley   +3 more
core   +1 more source

Indirect effects of Seeking Safety plus sertraline on alcohol use: The mediating role of reductions in posttraumatic stress disorder symptom severity

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) symptoms and alcohol use frequently co‐occur and are mutually reinforcing. Few studies have examined how changes in PTSD severity influence subsequent changes in alcohol use, particularly in the context of comorbidity treatments. This secondary analysis utilized data from a clinical trial comparing 12 weeks
Lesia M. Ruglass, Jordan A. Gette, Antonio A. Morgan‐López, Ai Ye, Kathryn Z. Smith, Skye Fitzpatrick, Teresa López‐Castro, Lissette M. Saavedra, Sonya B. Norman, Therese K. Killeen, Sudie E. Back, Denise A. Hien   +11 more
wiley   +1 more source

Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study

BMC Public Health
Background Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe.
Deirdre Mongan, Seán R. Millar, Anne Marie Carew, Cathy Kelleher, Antoinette Daly, Suzi Lyons, Brian Galvin, Bobby P. Smyth   +7 more
doaj   +1 more source

On the atomic structure of cocaine in solution [PDF]

, 2016
Cocaine is an amphiphilic drug which has the ability to cross the blood–brain barrier (BBB). Here, a combination of neutron diffraction and computation has been used to investigate the atomic scale structure of cocaine in aqueous solutions.
Biggin, Philip C., Busch, Sebastian, Callear, Samantha K., Johnston, Andrew J, McLain, Sylvia E., Pardo Soto, Luis Carlos   +5 more
core   +1 more source

Cold EI—The Way to Improve GC‐MS and Increase Its Range of Applications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Gas chromatography‐mass spectrometry (GC‐MS) with Cold electron ionization (EI) is based on interfacing the GC and MS with a supersonic molecular beam (SMB) along with electron ionization of vibrationally cold sample compounds in the SMB in a contact‐free fly‐through ion source (hence the name Cold EI).
Aviv Amirav, Benny Neumark, Oneg Elkabets, Alex Yakovchuk   +3 more
wiley   +1 more source

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

Scientific Reports
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6).
Huimei Wei, Johnathan E. LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng   +4 more
doaj   +1 more source

Corticostriatal cocaine-seeking ensembles are defined by differing gene expression from sucrose-seeking ensembles using a within-subject dual self-administration and seeking mouse model

Addiction Neuroscience
Recurrent cocaine seeking is a hallmark of cocaine use disorder. To develop therapeutic targets, it is critical to understand the neurobiological changes specific to cocaine-seeking in context with the seeking of non-drug rewards, e.g., sucrose.
Carl G. Litif, Levi T. Flom, Kathryn L. Sandum, Skylar L. Hodgins, Lucio Vaccaro, Jerry A. Stitzel, Nathan Ungerleider, Maria Constanza Mannino, Jason P. Gigley, Todd A. Schoborg, Ana-Clara Bobadilla   +10 more
doaj   +1 more source

Treading the fine white line: cocaine trafficking [PDF]

, 2016
The illicit drug’s trade is a highly profitable business that grasps the interest of millions of people and equally affects millions of others. Cocaine is a highly addictive drug that plagues many countries.
McNicholl, S, O'Hagan, A
core   +1 more source

Chemical Ionization Mass Spectrometry: Fundamental Principles, Diverse Applications, and the Latest Technological Frontiers

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The review examines the evolution of chemical ionization mass spectrometry (CI‐MS), a technique developed in 1966 by Field and Munson. CI is a soft‐ionization method that produces more intense molecular ions with less fragmentation than electron ionization (EI).
Malvika Dutt, Adriana Arigò, Giorgio Famiglini, Pierangela Palma, Achille Cappiello   +4 more
wiley   +1 more source

The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]

, 2013
Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag, A Meister, AA Tambe, AJ Cooper, CQ Chen, DA Baker, DA Baker, Danuta Kowalczyk-Pachel, DC Carter, DP Jones, E Bald, E Bald, Elżbieta Lorenc-Koci, G Chwatko, G Lund, GJ McBean, GJ McBean, Grażyna Chwatko, H Refsum, H Sato, H Turhan, HJ Forman, HJ Forman, HL Wiener, I Barutcu, I Dalle-Donne, I Dalle-Donne, JB Dietrich, JD Uys, JE Schnitzer, JI Toohey, JJ Mieyal, JM Mato, Joanna Czyżyk, K Fijał, KM Humphries, KS Kau, KS McCully, L Pomierny-Chamioło, L Włodek, LH Lash, Lidia Włodek, M Conrad, M Iciek, M Kemp, M Muriach, MA Evans, Małgorzata Filip, Małgorzata Iciek, NL Reynaert, O Stanger, P Klatt, P Kovacic, PN Mardikian, PW Beatty, PW Kalivas, R Banerjee, R Castro, R Labib, R Labib, RA Kloner, RC Twining, S Githens, S Kandil, S Sengupta, S Zaina, SA Everett, SC Lu, SD LaRowe, SE Hyman, SH Rezkalla, SL Amen, SZ Mehanny, T Fiaschi, T Visalli, V Vitvitsky, W Tian, W Zhou, YI Kim, YM Go, YM Kupchik   +80 more
core   +2 more sources