Results 81 to 90 of about 307,196 (303)

A latent class analysis of the past-30-day substance use patterns among lifetime cocaine users: Findings from a community sample in North Central Florida

Addictive Behaviors Reports, 2019
Objectives: Cocaine use is increasing and many cocaine users engage in polysubstance use. Within polysubstance use, relationships among use of individual substances are necessarily complex.
Yiyang Liu, Amy L. Elliott, Mirsada Serdarevic, Robert F. Leeman, Linda B. Cottler   +4 more
doaj   +1 more source

Ibrutinib as a potential therapeutic for cocaine use disorder

Translational Psychiatry, 2021
Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity.
Spencer B. Huggett, Jeffrey S. Hatfield, Joshua D. Walters, John E. McGeary, Justine W. Welsh, Trudy F. C. Mackay, Robert R. H. Anholt, Rohan H. C. Palmer   +7 more
doaj   +1 more source

The Effects of Cocaine on Different Redox Forms of Cysteine and Homocysteine, and on Labile, Reduced Sulfur in the Rat Plasma Following Active versus Passive Drug Injections [PDF]

, 2013
Received: 28 November 2012 / Revised: 19 April 2013 / Accepted: 6 May 2013 / Published online: 16 May 2013 The Author(s) 2013. This article is published with open access at Springerlink.comThe aim of the present studies was to evaluate cocaine ...
A Madayag, A Meister, AA Tambe, AJ Cooper, CQ Chen, DA Baker, DA Baker, Danuta Kowalczyk-Pachel, DC Carter, DP Jones, E Bald, E Bald, Elżbieta Lorenc-Koci, G Chwatko, G Lund, GJ McBean, GJ McBean, Grażyna Chwatko, H Refsum, H Sato, H Turhan, HJ Forman, HJ Forman, HL Wiener, I Barutcu, I Dalle-Donne, I Dalle-Donne, JB Dietrich, JD Uys, JE Schnitzer, JI Toohey, JJ Mieyal, JM Mato, Joanna Czyżyk, K Fijał, KM Humphries, KS Kau, KS McCully, L Pomierny-Chamioło, L Włodek, LH Lash, Lidia Włodek, M Conrad, M Iciek, M Kemp, M Muriach, MA Evans, Małgorzata Filip, Małgorzata Iciek, NL Reynaert, O Stanger, P Klatt, P Kovacic, PN Mardikian, PW Beatty, PW Kalivas, R Banerjee, R Castro, R Labib, R Labib, RA Kloner, RC Twining, S Githens, S Kandil, S Sengupta, S Zaina, SA Everett, SC Lu, SD LaRowe, SE Hyman, SH Rezkalla, SL Amen, SZ Mehanny, T Fiaschi, T Visalli, V Vitvitsky, W Tian, W Zhou, YI Kim, YM Go, YM Kupchik   +80 more
core   +2 more sources

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Trends in cocaine use and cocaine-related harms in Ireland: a retrospective, multi-source database study

BMC Public Health
Background Increased cocaine supply has coincided with increased global cocaine use. In 2019 Ireland had one of the highest last-year rates of cocaine use in Europe.
Deirdre Mongan, Seán R. Millar, Anne Marie Carew, Cathy Kelleher, Antoinette Daly, Suzi Lyons, Brian Galvin, Bobby P. Smyth   +7 more
doaj   +1 more source

Deletion of the GABAA α2-subunit does not alter self dministration of cocaine or reinstatement of cocaine seeking [PDF]

, 2014
Rationale GABAA receptors containing α2-subunits are highly represented in brain areas that are involved in motivation and reward, and have been associated with addiction to several drugs, including cocaine.
A Agrawal, AC Barrett, B. Halbout, C Schwarzer, C. I. Dixon, CI Dixon, CI Dixon, CI Dixon, D. N. Stephens, DM Dick, DM Thompson, EM Weerts, G Brown, HC Fox, HJ Edenberg, HN Katz, HV Morris, HV Morris, J Covault, J Merrer Le, JD Salamone, JR Taylor, K Low, KL Conrad, LA Knackstedt, LJ Herberg, LM Reynolds, LO Bauer, M Filip, M Filip, MA Enoch, MA Enoch, MJ Thomas, ND Volkow, P Waelti, PA Broderick, PA Lind, R Keiflin, R Sinha, RA Wise, RW Keller Jr, S Erb, S Pirker, S Taverna, S Villafuerte, S. L. King, SA Kushner, SH Ahmed, SL Dewey, SS Negus, TE Robinson, TW Robbins, TW Robbins, TW Robbins, W Schultz, Y Kawaguchi   +55 more
core   +1 more source

Decision‐making and risk‐taking as predictors of health risk behaviors in the Millennium Cohort Study

JCPP Advances, EarlyView.
Abstract Background Facets of decision‐making and risk‐taking are implicated in adolescent health risk behaviors; however, whether they may lead to adolescent engagement in substance use, gambling, and self‐harm is unknown. Methods We used the Millennium Cohort Study to test whether a task‐based measure of decision‐making and risk‐taking predicts ...
Nicole G. Hammond, Georgia Condran, Elise E. DeVito, Marie‐Claude Geoffroy, Ian Colman   +4 more
wiley   +1 more source

Long-lasting blocking of interoceptive effects of cocaine by a highly efficient cocaine hydrolase in rats

Scientific Reports
Cocaine dependence is a serious world-wide public health problem without an FDA-approved pharmacotherapy. We recently designed and discovered a highly efficient long-acting cocaine hydrolase CocH5-Fc(M6).
Huimei Wei, Johnathan E. LeSaint, Zhenyu Jin, Chang-Guo Zhan, Fang Zheng   +4 more
doaj   +1 more source

Stressor- and Corticotropin releasing Factor-induced Reinstatement and Active Stress-related Behavioral Responses are Augmented Following Long-access Cocaine Self-administration by Rats [PDF]

, 2008
Rationale Stressful events during periods of drug abstinence likely contribute to relapse in cocaine-dependent individuals. Excessive cocaine use may increase susceptibility to stressor-induced relapse through alterations in brain corticotropin-releasing
AM Basso, B Costall, B Costall, B Lee, B Wang, B Wang, BA Sorg, BA Sorg, CJ Sanchez, David A. Baker, David M. Francis, DJ Lodge, EB Souza De, EP Zorrilla, Eric S. Katz, G Paxinos, HC Fox, J Liu, John R. Mantsch, Joseph P. Serge, JR Mantsch, JR Mantsch, K McFarland, L Lu, L Lu, LJMJ Vanderschuren, LM Najavits, LW Swanson, MA Sutton, MA Ungless, Michael A. Hoks, N Capriles, NE Goeders, NE Goeders, NH Mutschler, PW Kalivas, PW Kalivas, R Sinha, R Sinha, RA Fuchs, RE Sorge, RM Richter, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Erb, S Pellow, S Pollandt, SH Ahmed, SH Ahmed, SH Ahmed, SH Ahmed, TE Kippin, TM Korotkova, V Deroche-Gamonet, Y Shaham, Y Zhou, Z Sarnyai, Z Sarnyai   +62 more
core   +2 more sources

Indirect effects of Seeking Safety plus sertraline on alcohol use: The mediating role of reductions in posttraumatic stress disorder symptom severity

Journal of Traumatic Stress, EarlyView.
Abstract Posttraumatic stress disorder (PTSD) symptoms and alcohol use frequently co‐occur and are mutually reinforcing. Few studies have examined how changes in PTSD severity influence subsequent changes in alcohol use, particularly in the context of comorbidity treatments. This secondary analysis utilized data from a clinical trial comparing 12 weeks
Lesia M. Ruglass, Jordan A. Gette, Antonio A. Morgan‐López, Ai Ye, Kathryn Z. Smith, Skye Fitzpatrick, Teresa López‐Castro, Lissette M. Saavedra, Sonya B. Norman, Therese K. Killeen, Sudie E. Back, Denise A. Hien   +11 more
wiley   +1 more source