Results 91 to 100 of about 47,059 (243)

The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models

Microorganisms
Cocaine use disorder remains a major global health concern, with growing evidence that the gut microbiome modulates drug-related behaviors. This study examines the microbiome’s role in cocaine-induced psychomotor activation and context-dependent reward ...
Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez   +5 more
doaj   +1 more source

The psychometric properties of validated tools to assess cannabis use disorder: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Aims To systematically review the evidence on the psychometric performance and accuracy of screening or diagnostic tools for cannabis use disorder. Method Systematic review and meta‐analysis which included studies conducted in clinical settings, schools, universities, community settings and population‐based surveys in multiple countries and ...
Janni Leung, Daniel Stjepanovic, Stephanie Fong, Danielle Dawson, Giang Vu, Tesfa Yimer, Caitlin McClure‐Thomas, Wayne Denis Hall, Gary Chung Kai Chan   +8 more
wiley   +1 more source

The feasibility of mindfulness‐based relapse prevention for adults with substance use disorders (illicit drugs) in a Chinese population: A pilot randomized controlled trial

Addiction, EarlyView.
Abstract Background and aims Mindfulness‐based relapse prevention (MBRP) has been shown to be beneficial to individuals with substance use disorder (SUD) in the West. The current pilot study aimed at testing the feasibility of MBRP in a Chinese population.
Ka Tsun Ting, Ivan Chun Him Leung, Dicken Cheong Chun Chan, Ken On Tai Yu, Wai Kwong Tang, Fu Chan, Alan Ka Lam Tang, Helen Shuk Wah Ma, Benjamin Hon Kei Yip, Daisy Dexing Zhang, Sarah Bowen, Samuel Yeung Shan Wong   +11 more
wiley   +1 more source

Alcohol vs. Cocaine: Impulsivity and Alexithymia in Substance Use Disorder

Behavioral Sciences
Substance Use Disorders (SUDs) are frequently associated with impairments in emotional regulation and behavioural control. Among the most prevalent substances of abuse, alcohol and cocaine are known to exert distinct effects on neuropsychological ...
Alessio Mosca, Giovanna Bubbico, Clara Cavallotto, Stefania Chiappini, Rita Allegretti, Andrea Miuli, Carlotta Marrangone, Nicola Ciraselli, Mauro Pettorruso, Giovanni Martinotti   +9 more
doaj   +1 more source

Substance‐related intrusive memories in cocaine use disorder are different from but associated with craving

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is a significant global health concern, characterized by persistent craving despite severe consequences. Recent theories highlight maladaptive memory processes – such as intrusive, vivid recollections of past substance use that arise spontaneously in daily life – as key contributors to craving and
Amelie Zacher, Lina Dietiker, Victoria Häffner, Francesco Bavato, Birgit Kleim, Boris B. Quednow   +5 more
wiley   +1 more source

Context, mechanisms and outcomes of a social enterprise model of residential rehabilitation for problem substance use: A realist‐informed process evaluation

Addiction, EarlyView.
Abstract Background and aims This study evaluated a three‐year residential rehabilitation programme, which aimed to support recovery from problem substance use via peer support and social enterprise activities. The aims were to clarify programme mechanisms and identify contextual factors associated with variation in outcomes.
Martin Anderson, Lucy Pickering, Mark McCann   +2 more
wiley   +1 more source

Charting the decline of the fourth wave: US overdose deaths by race, ethnicity and substance involvement

Addiction, EarlyView.
Abstract Aims To characterize decreases in overdose death rates in the United States (US) between 2023 and 2024 by race/ethnicity, and substance involvement. Design Population‐based study of national death records accessed via the Centers for Disease Control and Prevention (CDC) Wide‐ranging ONline Data for Epidemiologic Research (WONDER) platform ...
Joseph R. Friedman, Joseph J. Palamar, Daniel Ciccarone, Tommi L. Gaines, Annick Borquez, Chelsea L. Shover, Steffanie A. Strathdee   +6 more
wiley   +1 more source

Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens

Communications Biology
Cocaine use disorder is characterized by persistent drug-seeking behavior and a high risk of relapse, driven in part by lasting molecular and circuit adaptations in the nucleus accumbens. To explore the transcriptomic changes underlying these alterations,
Philipp Mews, Autumn VA Mason, Emily G. Kirchner, Molly Estill, Eric J. Nestler   +4 more
doaj   +1 more source

Hematological inflammatory biomarkers in patients with alcohol and cocaine use disorders

Trends in Psychiatry and Psychotherapy
Objective Neutrophil-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelets-lymphocyte ratio (PLR) are biomarkers easy-to-obtain and could be used in clinical practice to verify an inflammatory status and are associated with alcohol ...
Andressa Goldman Ruwel, Juliana Nichterwitz Scherer, Daiane Silvello, Felix Henrique Paim Kessler, Lisia von Diemen, Jaqueline Bohrer Schuch   +5 more
doaj   +1 more source

Characteristics of deaths due to drug‐related causes among individuals recently released from prison in the United Kingdom, 1997–2025

Addiction, EarlyView.
Abstract Background and aims There has been an extensive literature describing the elevated risk of drug‐related death following an individual's release from prison; however, few previous studies have reported nationally representative samples or provided granular detail as to which individual drugs were deemed implicated in death.
Emmert Roberts, John Strang, Caroline Copeland   +2 more
wiley   +1 more source