Results 81 to 90 of about 47,220 (255)

Change of substance‐related hospitalisation in adolescents after cannabis legalisation in Thailand in 2022

Addiction, EarlyView.
Abstract Background and aims On 9 June 2022, Thailand changed its cannabis legislation, expanding access to individuals aged >18 years. Evidence suggests that such changes could increase the risk of cannabis use and related harms, and could influence patterns of use of other substances among adolescents.
Sirada Puetpaiboon, Songyos Rajborirug, Vorthunju Nakhonsri, Chumpol Ngamphiw, Peerapat Khunkham, Sissades Tongsima, Watcharapot Janpoung, Virasakdi Chongsuvivatwong   +7 more
wiley   +1 more source

Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement

Frontiers in Genetics, 2016
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied.
Caitlin E Carey, Arpana Agrawal, Kathleen K Bucholz, Sarah M Hartz, Michael T Lynskey, Elliot C Nelson, Laura J Bierut, Ryan Bogdan   +7 more
doaj   +1 more source

Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cocaine use disorder (CUD) is an increasingly widespread concern worldwide. Various pharmacological treatments have been investigated for CUD, but their efficacy remains unclear, and none have been licensed for treatment.
Craig Paterson, Thomas Parkhouse, Chloe Burke, Monika Halicka, Jennifer C. Palmer, Hend Gabr, Rebecca Wilson, Katie E. Webster, Francesca Spiga, Sarah Dawson, Deborah M. Caldwell, Jennifer Scott, Julian P. T. Higgins, Jelena Savović   +13 more
wiley   +1 more source

Brain reward function in young people with cannabis use disorder: A functional magnetic resonance imaging study

Addiction, EarlyView.
Abstract Background and Aims Cannabis use disorder (CUD) affects ~50 million people globally. Neuroscientific theories suggest that a blunted neural response to non‐drug rewards is a hallmark of substance use disorders; however, this remains untested in CUD. The current study tested whether brain reward system responses to the anticipation and feedback
Martine Skumlien, Lisa‐Marie Greenwood, Arush Honnedevasthana Arun, Isabella Goodwin, Anastasia Paloubis, Tribikram Thapa Rana, Marianna Quinones Valera, Eugene McTavish, Gabrielle Abbott, Suraya Dunsford, Antonio Verdejo‐Garcia, Jessica Ramamurthy, Mark M. Schira, Nadia Solowij, Chao Suo, Valentina Lorenzetti   +15 more
wiley   +1 more source

Impact of SMAASH-C, a novel nutritional supplement, on drug-seeking and toxicity in female and male rats

Translational Psychiatry
Relapse to drug use after abstinence is a major challenge in treating substance use disorder. Exposure to drug-associated cues during abstinence can trigger intense craving and precipitate relapse.
Eleanor Blair Towers, Ivy L. Williams, Ariadne S. K. Aristidou, Ajibike O. Salako-Akande, Wendy J. Lynch   +4 more
doaj   +1 more source

Impulsiveness as a predictor of topiramate response for cocaine use disorder

The American Journal on Addictions, 2019
Background/ObjectivesTopiramate has been studied in the treatment of substance use disorders and is often used off‐label in the treatment of other disorders with impaired impulse control. We sought to determine whether impulsiveness could predict topiramate treatment response in individuals with cocaine use disorder (CUD).MethodsIn a post‐hoc analysis ...
Derek, Blevins, Xin-Qun, Wang, Sana, Sharma, Nassima, Ait-Daoud   +3 more
openaire   +3 more sources

Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial

Addiction, EarlyView.
Abstract Background and aims Individuals who engage in illicit or nonmedical opioid use may have elevated risk of health and social consequences, including progression to opioid use disorder (OUD). Preventive interventions to reduce this risk are lacking. This trial tested the impact of a primary care‐integrated collaborative care approach for reducing
Jennifer McNeely, Geetha A. Subramaniam, Rebecca Stone, Shayna Mazel, Noa Appleton, Yasna Rostam‐Abadi, Amanda M. Bunting, Yidan Shi, Travis I. Lovejoy, Lillian Gelberg, Donna Beers, Margaret Kline, Song Zhang, Tobie Kim, Ashley Case, Jennifer McCormack, Michael A. Incze, Jane M. Liebschutz, the STOP trial site principal investigators, Karen Alexander, Seuli Bose Brill, Sarah Kawasaki, Adam J. Gordon, Hyunouk Hong   +23 more
wiley   +1 more source

Craving and personal functioning as mediators of extended‐release buprenorphine efficacy: A four‐way decomposition analysis from a randomised trial

Addiction, EarlyView.
Abstract Aims To investigate whether the treatment effect of extended‐release buprenorphine (BUP‐XR) on opioid‐free days in opioid use disorder (OUD) is mediated by reductions in opioid craving and improvements in personal functioning. Design and setting Exploratory causal mediation analysis using VanderWeele's four‐way decomposition framework in a 24 ...
John Marsden, Mike Kelleher, Fiona Cowden, Edward Day, Jonathan Dewhurst, Rachel Evans, Eilish Gilvarry, Natalie Lowry, Luke Mitcheson, Robert Murray, Sophie Quarshie, Zoë Hoare   +11 more
wiley   +1 more source

Overdose reversal through peer intervention: Findings from the naloxone prospective outcome research study (NalPORS) on the effectiveness of overdose response by people who use opioids in the United Kingdom and Sweden

Addiction, EarlyView.
Abstract Background/aims Take‐home naloxone (THN) programmes have been introduced in many European countries to provide non‐medically trained people who are likely to witness an opioid overdose, including people who use opioids, with a naloxone kit and training.
Nicola Metrebian, Teodora Dascal, Clare Mackie, Rose Tinch‐Taylor, Ben Carter, Joanne Neale, Mariana Gonzalez Utrilla, Ed Day, Joar Guterstam, Kirsten Horsburgh, Martin Kåberg, Mike Kelleher, Soraya Mayet, Josie Smith, Desiree Eide, Elin Holmén, Rebecca McDonald, Stephen Parkin, Henrik Thiesen, John Strang, NalPORS Research Team, Dean Acreman, Shabana Akhtar, Louise Aitken, Martin Anderson, James Cassidy, Sarah Cosgrove, Jo Grayer, Michelle Hughes, Louise Horn, Anika Miah, John Pratt   +31 more
wiley   +1 more source

The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models

Microorganisms
Cocaine use disorder remains a major global health concern, with growing evidence that the gut microbiome modulates drug-related behaviors. This study examines the microbiome’s role in cocaine-induced psychomotor activation and context-dependent reward ...
Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez   +5 more
doaj   +1 more source