Results 61 to 70 of about 47,220 (255)

Stress as a Risk Factor for Substance Use Disorders: A Mini-Review of Molecular Mediators

Frontiers in Behavioral Neuroscience, 2018
The extant literature supports the role of stress in enhancing the susceptibility of drug abuse progressing to a substance use disorder diagnosis. However, the molecular mediators by which stress enhances the progression from cocaine abuse to cocaine use
Deepika Mukhara, Matthew L. Banks, Gretchen N. Neigh   +2 more
doaj   +1 more source

Clavulanic Acid Attenuated Cocaine Craving in Individuals with Cocaine Use Disorder

Psychopharmacology Bulletin
This randomized, controlled trial examined the safety of clavulanic acid (CLAV), a GLT-1 (astrocytic glutamate transporter) modulator, in combination with intravenous cocaine to determine whether CLAV can be safely studied in outpatients with cocaine use disorder who may continue to use cocaine.
Morrison, Mary F, Cunningham, Ronan, Walters, M Ingre, Yu, Daohai, Lu, Xiaoning, Maser, Joya, Kampman, Kyle M   +6 more
openaire   +2 more sources

Opportunities and Alliances: The Relational Dynamics of Criminal Collusion in Latin America

The British Journal of Sociology, EarlyView.
ABSTRACT Based on ethnographic fieldwork in Mexico and judicial wiretap analysis in Argentina, this paper shows that collusion between state actors and violent non‐state actors operates through fluid and competitive relational networks rather than stable hierarchies or fixed institutional arrangements.
Eldad J. Levy, Javier Auyero
wiley   +1 more source

Differences in Risk Factors for Severe Preeclampsia and HELLP Syndrome in Singleton Versus Twin Pregnancies: A Population‐Based Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether the associations between pre‐pregnancy risk factors and severe preeclampsia/eclampsia (SPE) and/or HELLP syndrome differ between singleton and twin pregnancies. Design A population‐based retrospective cohort study. Setting British Columbia (BC), Canada.
Mackenzie Campbell, Johanna Koegl, Jeffrey N. Bone, Sofia Nicolls, Janet Lyons, Chantal Mayer, Kenneth I Lim, Julie Van Schalkwyk, K. S. Joseph, Sarka Lisonkova, the ORQA group, A. Christoffersen‐Deb, S. Derikvand, S. John, L. Richter, M. Rougerie, Y. Sabr, M. Vidler   +17 more
wiley   +1 more source

Orbitofrontal sulcogyral morphology in patients with cocaine use disorder

Psychiatry Research: Neuroimaging, 2020
Orbitofrontal cortex (OFC) is thought to be involved in appropriate processing of rewarding stimuli, and abnormal OFC structure and function has been found in patients with substance use disorders. Atypical patterns of the H-sulcus in the OFC have been primarily identified with schizophrenia, but also with bipolar disorder, both of which are associated
Marisa A, Patti, Sarah, Wochele, Yirui, Hu, Paul S, Regier, Anna Rose, Childress, Vanessa, Troiani   +5 more
openaire   +3 more sources

From Conflicting Outcomes to Mutual Losses: How Punitive Responses to Problematic Substance Use Suppress Help‐Seeking and Cause Harm

Human Resource Management Journal, EarlyView.
ABSTRACT Problematic substance use (PSU) is a significant, inadequately managed people management challenge. Drawing on the conflicting outcomes and mutual losses perspectives on HRM and employee wellbeing, and using Job Demands‐Resources theory to explain underlying strain‐driven loss cycles, we examine factors shaping PSU and help‐seeking among 575 ...
Karen Maher, Aoife M. McDermott, Andrew Clements, Emmert Roberts, Sally Pezaro   +4 more
wiley   +1 more source

Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats

Pharmaceuticals
Background/Objectives: Cocaine use disorder is an intersecting issue in populations with HIV-1, further exacerbating the clinical course of the disease and contributing to neurotoxicity and neuroinflammation.
Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel   +5 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Independent associations and effect modification between lifetime substance use and recent mood disorder diagnosis with household food insecurity.

PLoS ONE, 2018
Poor mental health and substance use are associated with food insecurity, however, their potential combined effects have not been studied. This study explored independent associations and effect modification between lifetime substance use and mood ...
Karen M Davison, Cliff Holloway, Lovedeep Gondara, Anne S Hatcher   +3 more
doaj   +1 more source

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source