Results 41 to 50 of about 15,480,873 (292)

Risky decisions in a lottery task are associated with an increase of cocaine use

Frontiers in Psychology, 2016
Cocaine use disorder is associated with maladaptive decision-making behaviour, which strongly contributes to the harmful consequences of chronic drug use.
Amrei eWittwer, Lea M Hulka, Hans R. Heinimann, Matthias eVonmoos, Boris B Quednow   +4 more
doaj   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

Advanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine

Frontiers in Behavioral Neuroscience, 2020
Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this ...
M. Carmen Arenas, María Carmen Blanco-Gandía, José Miñarro, Carmen Manzanedo   +3 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Computational modelling of reinforcement learning and functional neuroimaging of probabilistic reversal for dissociating compulsive behaviours in gambling and cocaine use disorders

BJPsych Open
Background Individuals with cocaine use disorder or gambling disorder demonstrate impairments in cognitive flexibility: the ability to adapt to changes in the environment.
Katharina Zühlsdorff, Juan Verdejo-Román, Luke Clark, Natalia Albein-Urios, Carles Soriano-Mas, Rudolf N. Cardinal, Trevor W. Robbins, Jeffrey W. Dalley, Antonio Verdejo-García, Jonathan W. Kanen   +9 more
doaj   +1 more source

Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder

Scientific Reports, 2017
Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seeking and taking in humans. To determine if
Efrain A. Ribeiro, Joseph R. Scarpa, Susanna P. Garamszegi, Andrew Kasarskis, Deborah C. Mash, Eric J. Nestler   +5 more
doaj   +1 more source

Low doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical model

JCIS Open, 2023
Anti-cocaine vaccines are a promising therapeutic strategy for treating cocaine use disorders. Here we hypothesize that nanoemulsions (NE) or suspensions (SS) loaded with the calix [4]arene-based immunogen UFMG-V4N2 can induce the production of anti ...
Bruna Rodrigues Dias Assis, Paulo Sérgio de Almeida Augusto, Raissa Lima Gonçalves Pereira, Sordaini Maria Caligiorni, Brian Sabato, Larissa Pires do Espírito Santo, Karine Dias dos Reis, Leonardo da Silva Neto, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Maila Castro Lourenço das Neves, Ângelo de Fátima, Frederico Duarte Garcia, Gisele Assis Castro Goulart   +13 more
doaj   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

'A blizzard': Regional services fear growing scale of cocaine use.

, 2023
When it comes to Ireland's problems with cocaine, Joe Treacy does not mince his words. "I made the comment last year that it was snowing in Galway. You could 'up that’ and say it is now blowing a blizzard.
Cummins, Barry
core  

Cocaine or methamphetamine use during young adulthood following stimulant use for attention-deficit/hyperactivity disorder during adolescence.

, 2023
Importance: The prescribing of stimulant medications for attention-deficit/hyperactivity disorder (ADHD) has increased in the US. Prescription stimulants are one of the most commonly misused controlled substances during adolescence.
Schepis, Ty S, Wilens, Timothy E, Veliz, Phil T, McCabe, Vita V, Schulenberg, John E, McCabe, Sean Esteban   +5 more
core   +1 more source