Results 41 to 50 of about 47,059 (243)

Low doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical model

JCIS Open, 2023
Anti-cocaine vaccines are a promising therapeutic strategy for treating cocaine use disorders. Here we hypothesize that nanoemulsions (NE) or suspensions (SS) loaded with the calix [4]arene-based immunogen UFMG-V4N2 can induce the production of anti ...
Bruna Rodrigues Dias Assis, Paulo Sérgio de Almeida Augusto, Raissa Lima Gonçalves Pereira, Sordaini Maria Caligiorni, Brian Sabato, Larissa Pires do Espírito Santo, Karine Dias dos Reis, Leonardo da Silva Neto, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Maila Castro Lourenço das Neves, Ângelo de Fátima, Frederico Duarte Garcia, Gisele Assis Castro Goulart   +13 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Computational modelling of reinforcement learning and functional neuroimaging of probabilistic reversal for dissociating compulsive behaviours in gambling and cocaine use disorders

BJPsych Open
Background Individuals with cocaine use disorder or gambling disorder demonstrate impairments in cognitive flexibility: the ability to adapt to changes in the environment.
Katharina Zühlsdorff, Juan Verdejo-Román, Luke Clark, Natalia Albein-Urios, Carles Soriano-Mas, Rudolf N. Cardinal, Trevor W. Robbins, Jeffrey W. Dalley, Antonio Verdejo-García, Jonathan W. Kanen   +9 more
doaj   +1 more source

Gene Network Dysregulation in Dorsolateral Prefrontal Cortex Neurons of Humans with Cocaine Use Disorder

Scientific Reports, 2017
Metabolic and functional alterations of neurons in the dorsolateral prefrontal cortex (dlPFC) are thought to contribute to impulsivity, which is a hallmark of addictive behaviors that underlie compulsive drug seeking and taking in humans. To determine if
Efrain A. Ribeiro, Joseph R. Scarpa, Susanna P. Garamszegi, Andrew Kasarskis, Deborah C. Mash, Eric J. Nestler   +5 more
doaj   +1 more source

Detecting Small Vessel Pathology in Cocaine Use Disorder

Frontiers in Neuroscience, 2022
BackgroundCocaine use is associated with an increased risk of cerebrovascular accidents. Small vessel pathology has been linked to the risk of stroke in cocaine users, but can be challenging to detect on conventional magnetic resonance (MR) scans.
Marco Öchsner, Elijah Mak, Karen D. Ersche, Karen D. Ersche   +3 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Inclusion Complexations of Levamisole and Cocaine With Molecular Baskets. Fluorescence Displacement Assay for Detection of Cocaine and Its Adulterant Levamisole in Aqueous Media

Chemistry – A European Journal, EarlyView.
Levamisole is a common adulterant found in street‐distributed cocaine. Molecular baskets have been shown to form stable inclusion complexes with both substances. While levamisole inserts its benzene into the basket's cavity, cocaine utilizes its bicyclic ring for encapsulation.
Christopher T. Mortensen, Carson E. Ward, Nitesh Kumar, Logan Willemann, Ryan Lutz, Kailey Hughes, Zheng Zheng, Jovica D. Badjić   +7 more
wiley   +1 more source

Severe maternal and neonatal morbidity or mortality in forceps versus cesarean birth in the second stage of labor: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Approximately one in four first‐time mothers reach the second stage of labor but cannot have a spontaneous vaginal birth, necessitating an intervention such as forceps to facilitate birth. Objective This study synthesizes evidence comparing severe maternal morbidity (SMM) and neonatal morbidity or mortality (SNMM) following forceps ...
Irina I. Oltean, Abirami Kirubarajan, Giulia M. Muraca   +2 more
wiley   +1 more source

Dysfunctional Personality Beliefs Linked to Emotion Recognition Deficits in Individuals With Cocaine Addiction and Personality Disorders

Frontiers in Psychiatry, 2019
Background: Facial emotion recognition is impaired in addiction and personality disorders. Dysfunctional personality beliefs reflect negative interpersonal schemas that may underpin emotion recognition deficits.
Natalia Albein-Urios, Jose M. Martinez-Gonzalez, Oscar Lozano-Rojas, Oscar Lozano-Rojas, Antonio Verdejo-Garcia   +4 more
doaj   +1 more source

Gender‐based violence during pregnancy and adverse perinatal outcomes in an urban low‐ and middle‐income setting: A prospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the association between gender‐based violence (GBV) assessed in early pregnancy and adverse perinatal outcomes using relative and absolute effect measures in an urban low‐ and middle‐income setting. Methods We conducted a prospective cohort study including 3890 singleton pregnancies recruited from two public healthcare ...
Elsa Romelia Moreno‐Verduzco, Javier Perez Duran, Irma Eloisa Monroy‐Muñoz, Juan Mario Solis‐Paredes, Salvador Espino‐y‐Sosa, Raigam Martinez‐Portilla, Johnatan Torres‐Torres   +6 more
wiley   +1 more source