Results 21 to 30 of about 15,480,873 (292)

The Distribution of opiates, cocaine and their metabolites in skeletal muscle tissue and vitreous humour as an aid to post-mortem toxicological interpretation. [PDF]

Post-mortem blood drug concentrations vary greatly and as a consequence of post-mortem change and redistribution may not reflect the concentration at the time of death.
Rees, Kelly-Ann
core   +8 more sources

Pharmacotherapy for Cocaine Use Disorders

, 2021
Cocaine is one of the most commonly used substances worldwide. It has a strong addictive potential, which often leads to excessive consumption causing pronounced physical and psychological harm to users. There is currently no approved or effective medication to treat cocaine use disorders.
Quednow, Boris B, Engeli, Etna J E, Herdener, Marcus   +2 more
openaire   +2 more sources

Cocaine use disorder in females is associated with altered social decision-making: a study with the prisoner’s dilemma and the ultimatum game

BMC Psychiatry, 2019
Background Chronic cocaine use is associated with cognitive deficits, including poor performance on neuropsychological tasks of memory, executive functions, theory of mind and decision-making.
Thiago Wendt Viola, João Paulo Otolia Niederauer, Bruno Kluwe-Schiavon, Breno Sanvicente-Vieira, Rodrigo Grassi-Oliveira   +4 more
doaj   +1 more source

Calix[n]arene-based immunogens: A new non-proteic strategy for anti-cocaine vaccine

Journal of Advanced Research, 2022
Introduction: Cocaine use disorder is a significant public health issue without a current specific approved treatment. Among different approaches to this disorder, it is possible to highlight a promising immunologic strategy in which an immunogenic agent
Leonardo da Silva Neto, Angélica Faleiros da Silva Maia, Adriana Martins Godin, Paulo Sérgio de Almeida Augusto, Raissa Lima Gonçalves Pereira, Sordaini Maria Caligiorne, Rosemeire Brondi Alves, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Gisele Assis Castro Goulart, Felipe Terra Martins, Maila de Castro Lourenço das Neves, Frederico Duarte Garcia, Ângelo de Fátima   +13 more
doaj   +1 more source

Smoked cocaine in socially-depressed areas [PDF]

, 2010
Background: The main objectives of this study are to describe the smoked cocaine user's profile in socially-depressed areas and their needs from a harm-reduction perspective, to investigate their use of smoking crack and compare the acute effects between
Pons-Prat, Montserrat, Olga Díaz, Delás, Jordi, Elena Adán, Pons Montserrat, Díaz Olga, Aguas Compaired, M. (Margarita), Adan, Elena, Adán Elena, Margarita Aguas, Diaz, Olga, Montserrat Pons, Aguas Margarita, Jordi Delas, Delas Jordi, Fuertes Ricardo, Ricardo Fuertes, Fuertes, Ricardo   +17 more
core   +1 more source

Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial.

JAMA Netw Open
Importance Cocaine use disorder is a serious public health problem and no medications have been proven effective for its treatment. Objective To evaluate psilocybin in the treatment of cocaine use disorder.
Hendricks PS, Lappan SN, Shelton RC, Lahti AC, Cropsey KL, Johnson MW, Bradley M, Simonsson O, Davis LL, Grossman DH, Ortiz CE.   +10 more
europepmc   +2 more sources

Cocaine and Marijuana Polysubstance Use and Cocaine Use Disorder: Investigating Mediated Effects through Patterns of Cocaine Use

Journal of Dual Diagnosis, 2020
Cocaine use is on the rise and it is comorbid with marijuana use. We examined the association between lifetime cocaine + marijuana polysubstance use (CM PSU) versus cocaine only and lifetime cocaine use disorder (CocUD) and examined the potential mediation by cocaine use patterns.
Yiyang Liu, JeeWon Cheong, Barry Setlow, Linda B. Cottler   +3 more
openaire   +3 more sources

Case Report: CBD Cigarettes for Harm Reduction and Adjunctive Therapy in a Patient With Schizophrenia and Substance Use Disorder

Frontiers in Psychiatry, 2021
The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease.
Maximilian Meyer, Marc Walter, Stefan Borgwardt, Alexandra Scheidegger, Elisabeth Lang, Patrick Köck   +5 more
doaj   +1 more source

Bile acids modulate reinstatement of cocaine conditioned place preference and accumbal dopamine dynamics without compromising appetitive learning

Scientific Reports, 2023
Psychostimulants target the dopamine transporter (DAT) to elicit their psychomotor actions. Bile acids (BAs) can also bind to DAT and reduce behavioral responses to cocaine, suggesting a potential therapeutic application of BAs in psychostimulant use ...
Daniele Zanella, Nicholas K. Smith, J. Andrew Hardaway, Anna Marie Buchanan, Clarence H. Mullins, Aurelio Galli, Angela M. Carter   +6 more
doaj   +1 more source

Growing use of valproic acid in substance use disorders

European Psychiatry, 2022
Introduction Valproic acid is an antiepileptic drug used in different fields of Psychiatry. It is known mostly for its use in managing patients with bipolar affective disorder.
J. Romão, M. Gonçalves, M. Ribeiro, R. André, R. Saraiva, M. Abreu   +5 more
doaj   +1 more source