Results 1 to 10 of about 47,059 (243)

Ibrutinib as a potential therapeutic for cocaine use disorder [PDF]

Translational Psychiatry, 2021
Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity.
Spencer B. Huggett, Jeffrey S. Hatfield, Joshua D. Walters, John E. McGeary, Justine W. Welsh, Trudy F. C. Mackay, Robert R. H. Anholt, Rohan H. C. Palmer   +7 more
doaj   +4 more sources

Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder [PDF]

Frontiers in Psychiatry
BackgroundCocaine use disorder (CUD) is characterized by the continued use of cocaine despite serious impacts on life. This study focused on understanding the perspective of individuals with current CUD, individuals in CUD remission, and their supporters
Suzanne Maahs, Denise Leclair, Baltazar Gomez-Mancilla, Baltazar Gomez-Mancilla, Brian D. Kiluk, Velusamy Shanmuganathan Muthusamy, Partha S. Banerjee, Shyamashree Dasgupta, Katherine M. Waye   +8 more
doaj   +4 more sources

Subtypes of cocaine use disorder and their neurobehavioral profiles. [PDF]

Transl Psychiatry
Cocaine Use Disorder (CUD) afflicts over 1.4 million individuals in the United States alone. However, current treatments are largely ineffective, with up to 85% returning to use long-term. We posit that addressing functional heterogeneity underlying CUD is crucial for improving treatment success.
Brucar LR, Drossel G, Garza-Villarreal EA, Zilverstand A.   +3 more
europepmc   +3 more sources

Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence [PDF]

Frontiers in Psychiatry
Transcranial magnetic stimulation (TMS) has emerged as a promising intervention for cocaine use disorder (CUD). However, a key concern when employing TMS in CUD is the potential risk of seizures.
Caesar G. Imperio, Caesar G. Imperio, Eric Parmon, Eric Parmon, Vaughn R. Steele, Vaughn R. Steele, Vaughn R. Steele, Derek Blevins, Derek Blevins, Rebecca Chalme, Rebecca Chalme, Jonathan M. Wai, Jonathan M. Wai, Kathleen Brady, Markus Heilig, Colleen A. Hanlon, Colleen A. Hanlon, Frances R. Levin, Frances R. Levin, Diana Martinez, Diana Martinez   +20 more
doaj   +2 more sources

Trends and correlates of cocaine use and cocaine use disorder in the United States from 2011 to 2015 [PDF]

Drug and Alcohol Dependence, 2017
Recent epidemiological data suggest a resurgence in cocaine use (CU) and cocaine-related problems in the United States. Demographic trends and correlates of problem CU are needed to determine potential factors that may be influencing the increased trend and to inform targeted prevention and intervention strategies.Trends in any past-year CU, weekly CU,
Li-Tzy Wu
exaly   +3 more sources

Cocaine Use Disorder (CUD): Current Clinical Perspectives

Substance Abuse and Rehabilitation, 2022
Elizabeth KC Schwartz,1,2 Noah R Wolkowicz,1,2 Joao P De Aquino,1,2 R Ross MacLean,1,2 Mehmet Sofuoglu1,2 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; 2Department of Psychiatry, VA Connecticut Healthcare System, West
Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M   +4 more
doaj   +2 more sources

A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities [PDF]

Communications Biology
The biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. Prior work on the development and maintenance of substance use has largely focused on cortico-striatal circuits ...
Jocelyn A. Ricard, Loïc Labache, Ashlea Segal, Elvisha Dhamala, Carrisa V. Cocuzza, Grant Jones, Sarah W. Yip, Sidhant Chopra, Avram J. Holmes   +8 more
doaj   +2 more sources

N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder [PDF]

Frontiers in Psychiatry
BackgroundIndividuals with cocaine use disorder experience heightened motivation to pursue rewards tied to cocaine, often triggered by associated cues.
Etna J. E. Engeli, Katrin H. Preller, Nathalie M. Rieser, Nathalie M. Rieser, Johanna Klar, Johanna Klar, Philipp Staempfli, Lea M. Hulka, Matthias Kirschner, Matthias Kirschner, Erich Seifritz, Erich Seifritz, Marcus Herdener   +12 more
doaj   +2 more sources

Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis. [PDF]

Drug Alcohol Depend
There is limited research on the course of drug craving in treatment trials of stimulant use disorders. This study examined trajectories of cocaine craving and use and their associations with other outcomes of cocaine use disorder in pharmacotherapy trials of cocaine use disorder.In 1070 participants from 6 randomized controlled trials testing ...
Mojtabai R, Susukida R, Farokhnia M, Nguyen TQ, Leggio L, Bergeria C, Dunn KE, Aminesmaeili M.   +7 more
europepmc   +3 more sources

Connectome-based prediction of craving in gambling disorder and cocaine use disorder. [PDF]

Dialogues Clin Neurosci, 2023
Craving, involving intense and urgent desires to engage in specific behaviours, is a feature of addictions. Multiple studies implicate regions of salience/limbic networks and basal ganglia, fronto-parietal, medial frontal regions in craving in addictions.
Antons S, Yip SW, Lacadie CM, Dadashkarimi J, Scheinost D, Brand M, Potenza MN.   +6 more
europepmc   +4 more sources