Results 31 to 40 of about 47,220 (255)

Sex Specific Sleep Parameters Among People With Substance Use Disorder

Frontiers in Psychiatry, 2022
IntroductionSleep can have substantial impacts in substance use disorder (SUD) pathogenesis, treatment, and recovery. Sex differences exist in both sleep and SUD, but how sleep is uniquely associated with SUD by sex is not known.
Caitlin E. Martin, Caitlin E. Martin, Joseph M. Dzierzewski, Lori Keyser-Marcus, Emily K. Donovan, Tatiana Ramey, Dace S. Svikis, F. Gerard Moeller   +7 more
doaj   +1 more source

Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders

Frontiers in Psychiatry, 2018
AimsDespite alcohol being the most often used addictive substance among addicted patients, use of other substances such as cocaine has increased over recent years, and the combination of both drugs aggravates health impairment and complicates clinical ...
Nuria García-Marchena, David Ladrón de Guevara-Miranda, María Pedraz, Pedro Fernando Araos, Pedro Fernando Araos, Gabriel Rubio, Juan Jesús Ruiz, Francisco Javier Pavón, Antonia Serrano, Estela Castilla-Ortega, Luis J. Santín, Fernando Rodríguez de Fonseca   +11 more
doaj   +1 more source

BDNF as a therapeutic candidate for cocaine use disorders

Addiction Neuroscience, 2022
Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in different neuroadaptations during early withdrawal from cocaine self-administration than after one or more weeks of ...
openaire   +3 more sources

Transcranial Magnetic Stimulation as a Tool to Promote Smoking Cessation and Decrease Drug and Alcohol Use

Brain Sciences, 2023
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation.
Tal Harmelech, Colleen A. Hanlon, Aron Tendler   +2 more
doaj   +1 more source

Novel role of AMPK in cocaine reinforcement via regulating CRTC1

Translational Psychiatry, 2022
Repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs.
Xiao-Xing Liu, Fang-Lin Liu, Xin Li, Tang-Sheng Lu, Yi-Xiao Luo, Min Jian, Kai Yuan, Shi-Qiu Meng, Yan-Ping Bao, Jie Shi, Lin Lu, Ying Han   +11 more
doaj   +1 more source

Risky decisions in a lottery task are associated with an increase of cocaine use

Frontiers in Psychology, 2016
Cocaine use disorder is associated with maladaptive decision-making behaviour, which strongly contributes to the harmful consequences of chronic drug use.
Amrei eWittwer, Lea M Hulka, Hans R. Heinimann, Matthias eVonmoos, Boris B Quednow   +4 more
doaj   +1 more source

Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine

Frontiers in Behavioral Neuroscience, 2020
Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this ...
M. Carmen Arenas, María Carmen Blanco-Gandía, José Miñarro, Carmen Manzanedo   +3 more
doaj   +1 more source

Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis. [PDF]

Drug Alcohol Depend
There is limited research on the course of drug craving in treatment trials of stimulant use disorders. This study examined trajectories of cocaine craving and use and their associations with other outcomes of cocaine use disorder in pharmacotherapy trials of cocaine use disorder.In 1070 participants from 6 randomized controlled trials testing ...
Mojtabai R, Susukida R, Farokhnia M, Nguyen TQ, Leggio L, Bergeria C, Dunn KE, Aminesmaeili M.   +7 more
europepmc   +3 more sources

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Low doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical model

JCIS Open, 2023
Anti-cocaine vaccines are a promising therapeutic strategy for treating cocaine use disorders. Here we hypothesize that nanoemulsions (NE) or suspensions (SS) loaded with the calix [4]arene-based immunogen UFMG-V4N2 can induce the production of anti ...
Bruna Rodrigues Dias Assis, Paulo Sérgio de Almeida Augusto, Raissa Lima Gonçalves Pereira, Sordaini Maria Caligiorni, Brian Sabato, Larissa Pires do Espírito Santo, Karine Dias dos Reis, Leonardo da Silva Neto, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Maila Castro Lourenço das Neves, Ângelo de Fátima, Frederico Duarte Garcia, Gisele Assis Castro Goulart   +13 more
doaj   +1 more source