Results 31 to 40 of about 15,480,873 (292)
Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells
Frontiers in Physiology, 2020 Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301 ...
Luigia Rossi +13 more
doaj +1 more source
Sex Specific Sleep Parameters Among People With Substance Use Disorder
Frontiers in Psychiatry, 2022 IntroductionSleep can have substantial impacts in substance use disorder (SUD) pathogenesis, treatment, and recovery. Sex differences exist in both sleep and SUD, but how sleep is uniquely associated with SUD by sex is not known.
Caitlin E. Martin +7 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Frontiers in Psychiatry, 2018 AimsDespite alcohol being the most often used addictive substance among addicted patients, use of other substances such as cocaine has increased over recent years, and the combination of both drugs aggravates health impairment and complicates clinical ...
Nuria García-Marchena +11 more
doaj +1 more source
Matrix‐Activated Aptamer Sensors for Human Serum Analysis
Angewandte Chemie, EarlyView.The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux +8 more
wiley +2 more sources
BDNF as a therapeutic candidate for cocaine use disorders
Addiction Neuroscience, 2022 Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in different neuroadaptations during early withdrawal from cocaine self-administration than after one or more weeks of ...
openaire +3 more sources
Brain Sciences, 2023 Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation.
Tal Harmelech +2 more
doaj +1 more source
Hypospadias and cocaine use in pregnancy.
, 2021 A case study involving male dichorionic-diamniotic twins where hypospadias was noted in the delivery suite. First pass urine samples for toxicology was requested and both twins tested positive for cocaine metabolites in their urine.
Boyle, MA, Finnegan, J, O'Sullivan, D
core
Baseline cocaine demand predicts contingency management treatment outcomes for cocaine-use disorder.
, 2020 Cocaine use disorder (CUD) is a significant public health issue. Behavioral interventions such as contingency management (CM) have been demonstrated to be highly effective in promoting cocaine abstinence.
Stotts, Angela L +10 more
core +1 more source
Novel role of AMPK in cocaine reinforcement via regulating CRTC1
Translational Psychiatry, 2022 Repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs.
Xiao-Xing Liu +11 more
doaj +1 more source