Results 31 to 40 of about 47,059 (243)
Frontiers in Psychiatry, 2021 The treatment of patients with schizophrenia and substance use disorder poses a challenge for clinicians. Continued use of cannabis and cocaine can exacerbate psychotic symptoms and worsen the course of disease.
Maximilian Meyer +5 more
doaj +1 more source
Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells
Frontiers in Physiology, 2020 Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301 ...
Luigia Rossi +13 more
doaj +1 more source
Sex Specific Sleep Parameters Among People With Substance Use Disorder
Frontiers in Psychiatry, 2022 IntroductionSleep can have substantial impacts in substance use disorder (SUD) pathogenesis, treatment, and recovery. Sex differences exist in both sleep and SUD, but how sleep is uniquely associated with SUD by sex is not known.
Caitlin E. Martin +7 more
doaj +1 more source
Frontiers in Psychiatry, 2018 AimsDespite alcohol being the most often used addictive substance among addicted patients, use of other substances such as cocaine has increased over recent years, and the combination of both drugs aggravates health impairment and complicates clinical ...
Nuria García-Marchena +11 more
doaj +1 more source
BDNF as a therapeutic candidate for cocaine use disorders
Addiction Neuroscience, 2022 Cocaine self-administration disturbs intracellular signaling in multiple reward circuitry neurons that underlie relapse to drug seeking. Cocaine-induced deficits in prelimbic (PL) prefrontal cortex change during abstinence, resulting in different neuroadaptations during early withdrawal from cocaine self-administration than after one or more weeks of ...
openaire +3 more sources
Brain Sciences, 2023 Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive, drug-free, neural-circuit-based therapeutic tool that was recently cleared by the United States Food and Drug Associate for the treatment of smoking cessation.
Tal Harmelech +2 more
doaj +1 more source
Novel role of AMPK in cocaine reinforcement via regulating CRTC1
Translational Psychiatry, 2022 Repeated cocaine exposure causes compensatory neuroadaptations in neurons in the nucleus accumbens (NAc), a region that mediates reinforcing effects of drugs.
Xiao-Xing Liu +11 more
doaj +1 more source
Risky decisions in a lottery task are associated with an increase of cocaine use
Frontiers in Psychology, 2016 Cocaine use disorder is associated with maladaptive decision-making behaviour, which strongly contributes to the harmful consequences of chronic drug use.
Amrei eWittwer +4 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2020 Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this ...
M. Carmen Arenas +3 more
doaj +1 more source
Advanced Science, EarlyView.ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source