PLoS ONE, 2015 Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders.
María Pedraz +18 more
doaj +4 more sources
Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms [PDF]
Molecules, 2019 Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors
Claudia Calpe-López +2 more
doaj +6 more sources
Threat Conditioning Prior to Cocaine or Sucrose Exposure Alters Reward-Seeking Behavior in a Sex-Dependent Manner [PDF]
Psychiatry InternationalBackground/Objectives: Research has shown a high prevalence of co-occurring trauma-related disorders and cocaine use disorder (CUD). However, there remains a need for preclinical studies to determine how traumatic event exposure influences vulnerability ...
Yobet Perez-Perez +11 more
doaj +2 more sources
Cocaine Upregulates Microglial Lipid Droplet Formation Through Increasing Lipid Synthesis Activity In Vitro and In Vivo [PDF]
BiomoleculesA novel subtype of microglia, lipid droplet accumulation microglia (LDAMs), has been identified in the aged brain, which is characterized by sustained inflammation and senescent-like phenotypes.
Yan Cheng +5 more
doaj +2 more sources
Cocaine use disorder, mental health diagnoses, and serious mental illness characteristics in mental health treatment. [PDF]
PLOS Mental HealthOver half of treatment-seeking individuals with a cocaine use disorder have a co-occurring mental health disorder. Mental health disorder symptoms may impact an individual's functioning so severely that they are classified as a serious mental illness ...
Orrin D Ware +2 more
doaj +2 more sources
ECM remodeling in the mPFC exacerbates cocaine-induced hyperactivity and impairs threat vigilance [PDF]
Translational PsychiatryThe extracellular matrix (ECM) plays a crucial role in addiction-related neuroplasticity. While chondroitinase ABC (chABC)-mediated ECM degradation has been shown to impair drug-conditioned place preference, its effects on cocaine-induced locomotor ...
Xiaorui Lin +11 more
doaj +2 more sources
Assessment of cognitive functioning using the Mini Mental State Examination in men with alcohol and crack cocaine use disorder [PDF]
Trends in Psychiatry and Psychotherapy, 2023 Introduction Consumption of substances has been associated with cognitive impairment. The Mini Mental State Examination (MMSE) is an easy-to-apply screening tool used to assess cognitive functions.
Jaqueline B. Schuch +9 more
doaj +1 more source
Severe rhabdomyolysis induced by cocaine contaminated with caffeine: a case report [PDF]
Asia Pacific Journal of Medical Toxicology, 2020 Background: Global consumption of illicit substances has increased, and cocaine dependence remains an important public health problem. Currently, the use of adulterants can overlap or exacerbate the symptoms of cocaine intoxication hindering the ...
Maria Monotya-Giraldo +3 more
doaj +1 more source
Pancreatitis aguda asociada a cocaína, una complicación inusual. Serie de casos
Medicina U.P.B., 2023 La cocaína es una de las sustancias ilegales más consumidas y Colombia no es la excepción. Dentro de las sustancias ilegales es la segunda más consumida después del cannabis.
Juan David Blanco +2 more
doaj +1 more source
Drug abuse and serum nutritional biomarkers: A retrospective cohort study
Revista Española de Nutrición Humana y Dietética, 2021 Introduction: Drug abuse is a public health problem around the globe. Its implications in human health are harmful, compromising nutritional status.
Alfonso Daniel Silva Ochoa +5 more
doaj +1 more source