Results 11 to 20 of about 11,001,215 (252)

An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system [PDF]

Science Advances, 2021
The addictive effects of cocaine are regulated by an autophagy protein and can be prevented by autophagy inhibitors. Drug abuse is a foremost public health problem. Cocaine is a widely abused drug worldwide that produces various reward-related behaviors.
Yoon-Jin Kim, Qing-Yao Kong, Soh Yamamoto, K. Kuramoto, Mei Huang, Nan Wang, Jung-Hwa Hong, Tong Xiao, B. Levine, Xian-Xiu Qiu, Yan-Xiang Zhao, Richard J. Miller, Hong-Xin Dong, H. Meltzer, Ming Xu, Cong-Cong He   +15 more
semanticscholar   +2 more sources

Cannabidiol Treatment Might Promote Resilience to Cocaine and Methamphetamine Use Disorders: A Review of Possible Mechanisms [PDF]

Molecules, 2019
Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors
Claudia Calpe-López, M. Pilar García-Pardo, Maria A. Aguilar   +2 more
doaj   +4 more sources

An investigation of the relationship between borderline personality disorder and cocaine-related attentional bias following trauma cue exposure: The moderating role of gender [PDF]

Comprehensive Psychiatry, 2014
Elevated rates of borderline personality disorder (BPD) have been found among individuals with substance use disorders (SUDs), especially cocaine-dependent patients. Evidence suggests that cocaine-dependent patients with BPD are at greater risk for negative clinical outcomes than cocaine-dependent patients without BPD and BPD-SUD patients dependent on ...
Joseph R, Bardeen, Katherine L, Dixon-Gordon, Matthew T, Tull, Judith A, Lyons, Kim L, Gratz   +4 more
openaire   +3 more sources

Homeopathy on the integrative care of cocaine-related disorders (Cocacrack-3 Study): Updated Protocol for a randomized, placebo-controlled, double-blind, crossover clinical trial

International Journal of High Dilution Research - ISSN 1982-6206
Background: Effective pharmacotherapy for Cocaine Use Disorder is needed. The Cocacrack-2 study showed that homeopathic fifty-millesimal potencies of Opium and Erythroxylum coca were more effective than a placebo in reducing cocaine/crack use. However, the study experienced high dropout rates, which are common in the study population but could ...
Ubiratan Cardinalli Adler, Karen Berenice Denez, Maria Ligia dos Reis Bellaguarda, Lia Lira Olivier Sanders, Eugênio de Moura Campos, Matheus de Matos Dourado Simões, Tainá Rocha Josino, Marcos Alan Sousa Barbosa, Heloisa São Thiago da Costa Pereira, Rinaldo Ferreira, Erlandson Uchôa Lacerda, Elaine Cristina Coelho Baptista, Javier Salvador Gamarra Junior, Maristela Schiabel Adler, Edson Zangiacomi Martinez   +14 more
openaire   +2 more sources

Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity.

PLoS ONE, 2015
Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders.
María Pedraz, Ana Isabel Martín-Velasco, Nuria García-Marchena, Pedro Araos, Antonia Serrano, Pablo Romero-Sanchiz, Juan Suárez, Estela Castilla-Ortega, Vicente Barrios, Rafael Campos-Cloute, Juan Jesús Ruiz, Marta Torrens, Julie Ann Chowen, Jesús Argente, Rafael de la Torre, Luis Javier Santín, María Ángeles Villanúa, Fernando Rodríguez de Fonseca, Francisco Javier Pavón   +18 more
doaj   +2 more sources

Inflammatory mediators and dual depression: Potential biomarkers in plasma of primary and substance-induced major depression in cocaine and alcohol use disorders.

PLoS ONE, 2019
Major depressive disorder (MDD) is the most prevalent comorbid mental disorder among people with substance use disorders. The MDD can be both primary and substance-induced and its accurate diagnosis represents a challenge for clinical practice and ...
Nuria García-Marchena, Marta Barrera, Joan Ignasi Mestre-Pintó, Pedro Araos, Antonia Serrano, Clara Pérez-Mañá, Esther Papaseit, Francina Fonseca, Juan Jesús Ruiz, Fernando Rodríguez de Fonseca, Magí Farré, Francisco Javier Pavón, Marta Torrens   +12 more
doaj   +2 more sources

Homeopathy for Cocaine-Related Disorders: Implementing a Study Protocol in Primary Care (Cocacrack-3 Study Protocol)

Journal of Addiction Science, 2020
Introduction: Previous results showed a significant decrease in cocaine-using days among cocaine users treated homeopathic fifty-millesimal (LM) potencies of Opium and Erythroxylum coca, as compared to placebo. Those results might have been biased by low
Ubiratan Cardinalli Adler, Noemia Liege Maria da Cunha Bernardo, Karen Berenice Denez, João Gabriel Bernardo Bueno, Clarice Maria Specht, Maria Celina Ribeiro Lenzi, Angela Maria da Silva Hoepfner, Janayna Sobota, Simone do Nascimento Gonçalves, Amarilys de Toledo Cesar, Maristela Schiabel Adler, Erlandson Uchoa Lacerda, Edson Zangiacomi Martinez, José Carlos Fernandes Galduróz   +13 more
openaire   +2 more sources

B-10SPECT Imaging in Adults with Cocaine-Related Disorders [PDF]

Archives of Clinical Neuropsychology, 2016
J Garcia, R Okolichany, M Blose, G Vitale, C Golden, D Amen, K Willeumier, D Taylor   +7 more
openaire   +2 more sources

Main mental disorders in crack-cocaine users treated at Psychosocial Care Centers for Alcohol and Drugs in the city of Recife, Brazil

Trends in Psychiatry and Psychotherapy
Introduction: Brazil's Northeast region has the highest crack-cocaine consumption in the country. Crack-cocaine has more intense effects than cocaine powder and can cause greater chemical dependence.
Antonio Gomes de Castro Neto, Diego César Nunes da Silva, Magda da Silva Figueiroa   +2 more
doaj   +2 more sources

Levetiracetam Has Opposite Effects on Alcohol- and Cocaine-Related Behaviors in C57BL/6J Mice [PDF]

Neuropsychopharmacology, 2013
The antiepileptic drug levetiracetam (LEV) is a potential treatment for alcohol use disorders, yet few preclinical studies exist on its effects in animal models relevant to drug or alcohol abuse.
J. E. Robinson, Meng Chen, A. M. Stamatakis, Michael C. Krouse, Elaina C. Howard, S. Faccidomo, C. Hodge, E. Fish, C. J. Malanga   +8 more
semanticscholar   +2 more sources