Results 111 to 120 of about 36,767 (171)
Update on Gene Therapy in the Treatment of Hereditary Hearing Loss
Sensory Neuroscience, EarlyView.Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He +7 more
wiley +1 more source
Biomimetic Robotics and Intelligence: A Survey
SmartBot, EarlyView.Biomimetic robotics and intelligence, inspired by biological systems, integrate biology, engineering, and AI, develops robots capable of adapting to complex environments. By mimicking natural structures and cognitive processes, and employing algorithms like neural networks and genetic algorithms, these systems enhance autonomy and problem‐solving. This
Yixuan Sheng +6 more
wiley +1 more source
Veterinary Record, EarlyView.Abstract Background Disorders of the vestibular system are frequent in cats. This study aimed to describe the clinical presentation, diagnostic findings, underlying aetiologies and outcome of cats with peripheral vestibular syndrome (PVS). Methods This was a retrospective study of cats presented with PVS at four referral hospitals.
Jordina Caldero Carrete +5 more
wiley +1 more source
Designer breed dogs (canis lupus familiaris) with aggression and hyperactivity
Veterinary Record Case Reports, EarlyView.Abstract We describe two cases of designer breed dogs presented for behavioural issues to the Animal Behavioural Clinic of Utrecht University. A 1.5‐year‐old, entire cockapoo male was presented for aggression towards people, hyperactivity and separation‐related behaviour.
Silvia M. A. Gardeweg +3 more
wiley +1 more source
Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
A High‐Throughput Ancient DNA Extraction Method for Large‐Scale Sample Screening
Molecular Ecology Resources, Volume 25, Issue 4, May 2025.ABSTRACT Large‐scale DNA screening of palaeontological and archaeological collections remains a limiting and costly factor for ancient DNA studies. Several DNA extraction protocols are routinely used in ancient DNA laboratories and have even been automated on robotic platforms.
Alexandre Gilardet +11 more
wiley +1 more source
Molecular Ecology Resources, EarlyView.ABSTRACT Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high‐frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis
Xue Wang +14 more
wiley +1 more source
Aging Cell, EarlyView.TAK1‐mediated necroptotic pathways play an important role in the pathogenesis of ARHL. ABSTRACT Inflammation plays an important role in age‐related hearing loss (ARHL). Transforming growth factor‐β‐activated protein 1 (TAK1), a key factor upstream of inflammatory pathways, mediates various cell death pathways, potentially influencing the survival and ...
Hanjing Wang +10 more
wiley +1 more source
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy
Aging Cell, EarlyView.In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding +8 more
wiley +1 more source