Results 111 to 120 of about 66,419 (330)

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

PLoS ONE, 2014
The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promote the regeneration of sensory hair cells in the mature cochlea and their reconnection with auditory neurons through the ...
Patrick J Atkinson, A. Wise, B. Flynn, B. Nayagam, R. Richardson   +4 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

Advanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma, Weiping Wen, Dongdong Ren, Tianyu Zhang, Zhaoxu Tu   +13 more
wiley   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

IV. The cochlea of the ornithorhynchus platypus compared with that of ordinary mammals and of birds [PDF]

, 1881
Urban Pritchard
openalex   +1 more source

Bioinspired Intelligent Soft Robotics: From Multidisciplinary Integration to Next‐Generation Intelligence

Advanced Science, EarlyView.
Soft robotics, featuring intrinsic compliance and biomimetic adaptability, emerges as transformative in next‐generation intelligent systems. This review outlines how advancements in four foundational domains—actuation, materials, manufacturing, and control—drive the evolution of bioinspired intelligent soft robotics, poised to redefine the boundaries ...
Xiaopeng Wang, Ruilai Wei, Zhongming Chen, Hao Pang, Haotian Li, Yang Yang, Qilin Hua, Guozhen Shen   +7 more
wiley   +1 more source

Parametric Design of Continuum Robots Using Interlocking Ball Joints

Advanced Intelligent Systems, EarlyView.
Herein, a parametric design methodology is introduced for producing a wide variety of modular ball joint‐based continuum robots. It is demonstrate by designing a magnetically actuated continuum robot for cardiac ablations. The methodology is released as an open‐source computer‐assisted design extension that automatically designs continuum robots based ...
Alexandre Mesot, Quentin Boehler, Florian Heemeyer, Sean Lyttle, Buse Aktaş, Bradley J. Nelson   +5 more
wiley   +1 more source

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

Molecular Therapy: Methods & Clinical Development, 2022
The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively ...
Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti   +12 more
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