Results 111 to 120 of about 67,013 (327)
Scientific Reports, 2015 Pannexin1 (Panx1) is a gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface. Panx1 channels can release ATP under physiological conditions and play critical roles in many physiological and ...
Jin Chen +4 more
semanticscholar +1 more source
Ipsilateral cochlear implantation in cases with vestibular schwannoma
Eye &ENT Research, EarlyView.Abstract Background Vestibular schwannomas (VS) are the most common tumors in the cerebellopontine angle, which can lead to hearing loss, particularly following tumor resection. For patients with bilateral VS associated with neurofibromatosis type 2 (NF2), hearing loss significantly undermines their quality of life.
Qian Wan +7 more
wiley +1 more source
PLoS Genetics, 2019 The mouse organ of Corti, housed inside the cochlea, contains hair cells and supporting cells that transduce sound into electrical signals. These cells develop in two main steps: progenitor specification followed by differentiation.
Lu M Yang +3 more
doaj +1 more source
Intracochlear PLGA based implants for dexamethasone release: Challenges and solutions
International Journal of Pharmaceutics: X, 2019 The effective treatment of diseases of the inner ear is currently an unmet medical need. Local controlled drug delivery to the cochlea is challenging due to the hidden location, small volume and high sensitivity of this organ.
E. Lehner +4 more
doaj +1 more source
Investigating the mechanisms of capsicum in age‐related hearing loss: Based on network pharmacology
Eye &ENT Research, EarlyView.Abstract Background To explore the material basis and action mechanism of the chemical component gene of pepper on presbycusis, and to provide a reference for the traditional Chinese medicine treatment of age‐related hearing loss (ARHL). Methods The chemical composition and action targets of traditional Chinese medicine flavor of pepper were searched ...
Yan Wang +9 more
wiley +1 more source
Eye &ENT Research, EarlyView.Abstract Background Hearing loss, affecting 20% of the global population, disproportionately impacts low‐ and middle‐income countries, including Africa. Sensorineural hearing loss (SNHL) is prevalent among hemodialysis patients. In Tanzania, the growing number of hemodialysis patients highlights the need for hearing assessments.
Abdallah Jonas +6 more
wiley +1 more source
Food Frontiers, EarlyView.Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz +3 more
wiley +1 more source
β-Catenin Is Required for Hair-Cell Differentiation in the Cochlea
Journal of Neuroscience, 2014 The development of hair cells in the auditory system can be separated into steps; first, the establishment of progenitors for the sensory epithelium, and second, the differentiation of hair cells.
Fuxin Shi +5 more
semanticscholar +1 more source
New insights into applications of base editor in hereditary disorders
Interdisciplinary Medicine, EarlyView.Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai +8 more
wiley +1 more source