Results 121 to 130 of about 67,013 (327)

Hair Cell Regeneration after ATOH1 Gene Therapy in the Cochlea of Profoundly Deaf Adult Guinea Pigs

open access: yesPLoS ONE, 2014
The degeneration of hair cells in the mammalian cochlea results in permanent sensorineural hearing loss. This study aimed to promote the regeneration of sensory hair cells in the mature cochlea and their reconnection with auditory neurons through the ...
Patrick J Atkinson   +4 more
semanticscholar   +1 more source

Six Hundred and Sixty Nanometer Light Exposure‐Induced Alterations in Actin Filament, Mitochondrial Morphological Dynamics, and Migration in Mesenchymal Stem Cells

open access: yesJournal of Biophotonics, EarlyView.
Six hundred and sixty nanometer light‐induced alteration of actin filament cytoskeleton, mitochondrial morphological dynamics, and enhanced migration in adipose‐derived mesenchymal stem cells. ABSTRACT Actin cytoskeleton alteration and cell homing/migration are crucial determinants for the success of stem cell (SC) based therapy.
Mahima Rastogi   +2 more
wiley   +1 more source

Systematic Review of Quality of Life in Bone Anchored Hearing: Conductive vs. Unilateral Sensorineural Hearing Loss

open access: yesThe Laryngoscope, EarlyView.
The literature demonstrates that bone‐anchored hearing implants have a positive impact on auditory performance and quality of life (QoL), but these outcomes may not always correlate. This systematic review analyzed 56 articles to identify discrepancies in self‐reported, disease‐specific QoL benefits among patients with either unilateral sensorineural ...
Karina Théorêt   +4 more
wiley   +1 more source

Synchrotron‐Based Trauma Assessment of Robotic Electrode Insertions in Cochlear Implantation

open access: yesThe Laryngoscope, EarlyView.
Minimizing intraoperative trauma during cochlear implant electrode insertion is crucial for preserving residual hearing, and efforts have been made to introduce robotic systems for electrode insertion. On temporal bone specimens, the OTODRIVE system demonstrated its ability to enable consistent and controlled electrode placement while minimizing trauma
Joseph M. Chen   +7 more
wiley   +1 more source

Fate of Embryonic Stem Cells Transplanted into the Deafened Mammalian Cochlea

open access: yesCell Transplantation, 2006
Spiral ganglion neurons (SGNs), the primary afferent neurons of the cochlea, degenerate following a sensorineural hearing loss (SNHL) due to lack of trophic support normally received from hair cells.
B. Coleman   +6 more
doaj   +1 more source

Long‐Term Cochlear Implant Sensitivity in Patients With Far Advanced Otosclerosis

open access: yesThe Laryngoscope, EarlyView.
This study aimed to evaluate mid‐ and long‐term cochlear implant fitting in otosclerosis patients compared to a control group. It suggested significant tissue remodeling at the cochlear apex in otosclerosis patients, likely increasing resistance to electrical currents delivered by the implant.
Raphaële Quatre   +3 more
wiley   +1 more source

Robotic‐Assisted Electrode Array Insertion Improves Rates of Hearing Preservation

open access: yesThe Laryngoscope, EarlyView.
The purpose of our study is to understand the extent to which robotic‐assisted electrode array (EA) insertion improves hearing preservation. Our results show that robotic‐assisted EA insertion is associated with improved hearing preservation over 1 year compared with manual insertion.
Uzair A. Khan   +6 more
wiley   +1 more source

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