Results 121 to 130 of about 36,767 (171)

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Severe‐to‐Profound Hearing Loss and Mental Health: Initial Evidence That Cochlear Implantation Helps Alleviate Symptoms of Anxiety and Stress

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Mental‐health issues accounted for 418 million disability‐adjusted life years in 2019, costing the world economy approximately $5 trillion. Untreated hearing loss is a well‐known modifiable risk factor for mental‐health issues, with severe‐to‐profound hearing loss having the largest impact. Therefore, treatment of severe‐to‐profound
Paul McIlhiney, Osvaldo P. Almeida, Catherine M. Sucher, Robert H. Eikelboom, Dona M. P. Jayakody   +4 more
wiley   +1 more source

Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review

Clinical Otolaryngology, EarlyView.
ABSTRACT Objective Sudden sensorineural hearing loss (SSNHL) is an otologic emergency and is treated with steroid therapy. Despite adverse events (AEs) associated with long‐term steroid use being well evidenced, there is sparsity of literature regarding the AEs of short‐course prescriptions in the SSNHL cohort, which limits the quality of patient ...
M. Achanta, P. Kasetti, M. Fortune‐Ely, T. Ross, T. Magos, J. G. Manjaly   +5 more
wiley   +1 more source

Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors

Cell Proliferation, Volume 58, Issue 4, April 2025.
A combination of Ascl1, Pou4f1 and Myt1l was identified to promote functional reprogramming of cochlear spiral ganglion neurons based on biochemical, electrophysiological and single‐cell transcriptomic analyses. Abstract Degeneration of the cochlear spiral ganglion neurons (SGNs) is one of the major causes of sensorineural hearing loss and ...
Yuhang Huang, Zhen Chen, Jiang Chen, Jingyue Liu, Cui Qiu, Qing Liu, Linqing Zhang, Guang‐Jie Zhu, Xiaofeng Ma, Shuohao Sun, Yun Stone Shi, Guoqiang Wan   +11 more
wiley   +1 more source

Conditional Overexpression of Net1 Enhances the Trans‐Differentiation of Lgr5+ Progenitors into Hair Cells in the Neonatal Mouse Cochlea

Cell Proliferation, Volume 58, Issue 4, April 2025.
This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin, Qiuyue Zhang, Wei Tong, Yintao Wang, Leilei Wu, Hairong Xiao, Xujun Tang, Mingchen Dai, Zixuan Ye, Renjie Chai, Shasha Zhang   +10 more
wiley   +1 more source

Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells

Cell Proliferation, EarlyView.
Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai, Kun Huang, Wenrui Li, Tianming Wang, Shen Yue, Zhibin Chen, Guangqian Xing, Qinjun Wei, Jun Yao, Xin Cao   +9 more
wiley   +1 more source

The complete absence of cytoplasmic γ‐actin results in no discernible phenotype in mice or primary fibroblasts

The FEBS Journal, EarlyView.
Mice and mouse embryonic fibroblasts homozygous for an Actg1 allele edited to translate β‐actin instead of γ‐actin (Actg1‐coding beta) are devoid of γ‐actin protein. We demonstrate that these Actg1c‐b/c‐b mice present with no measurable phenotype in survival, body mass, activity, muscle contractility, or auditory function.
Lauren J. Sundby, Katelin M. Hawbaker, Jacob Powers, William M. Southern, Erynn E. Johnson, Xiaobai Patrinostro, Benjamin J. Perrin, James M. Ervasti   +7 more
wiley   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Evaluation of the endocranial anatomy of the early Paleogene north African gavialoid crocodylian Argochampsa krebsi and evolutionary implications for adaptation to salinity tolerance in marine crocodyliforms

Journal of Anatomy, Volume 246, Issue 6, Page 974-986, June 2025.
Abstract Argochampsa krebsi is a gavialoid crocodylian from the early Paleogene of North Africa. Based on its recovered phylogenetic relationship with South American species, it has been inferred to have been capable of transoceanic dispersal, but potential anatomical correlates for a marine lifestyle have yet to be identified.
Carly C. Pligersdorffer, Paul M. J. Burke, Philip D. Mannion   +2 more
wiley   +1 more source

Semicircular canal morphology in Rodentia and its relationship to locomotion

Journal of Anatomy, EarlyView.
Here, we present a selection of rodent inner ear 3D models in the lateral view, with rodents from seven locomotor categories (left to right: fossorial, semifossorial, semiaquatic, terrestrial, ricochetal, arboreal, and gliding). Semicircular canal (SCC) morphology, including radius of curvature and shape, can be differentiated between specialized forms
Lily Hou, Ornella C. Bertrand, Hiruni N. Mudannayake, Campbell Rolian, Susanne Cote   +4 more
wiley   +1 more source