Results 81 to 90 of about 107,745 (350)

Spontaneous Ca²⁺ signals in the developing mammalian cochlea of live mice under different anaesthetic regimes. [PDF]

Exp Physiol
Abstract The pre‐hearing mouse cochlea undergoes critical periods of spontaneous Ca2+‐dependent activity that spreads across non‐sensory supporting cells and inner hair cells (IHCs). These signals have been shown to regulate not only the refinement of neural circuits along the auditory pathway towards functional maturity, but also the maturation of the
De Faveri F, Marcotti W, Ceriani F.
europepmc   +2 more sources

Purinergic Signalling in the Cochlea

International Journal of Molecular Sciences, 2022
The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised structure that supports unique operating mechanisms. ATP release from the secretory tissues of the cochlear lateral wall (stria vascularis) triggers numerous physiological responses by activating P2 receptors in sensory, supporting and neural tissues.
Srdjan M. Vlajkovic, Peter R. Thorne
openaire   +2 more sources

Perception space - The final frontier [PDF]

, 2005
Mapping the complex sensory behavior of animals, such as smell in bees, to relevant neural activity provides clues into how animals perceive and respond to the world through their ...
Brockmann, A, Chittka, L
core   +3 more sources

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice. [PDF]

PLoS ONE, 2008
Connexin26 (Cx26) and connexin30 (Cx30) are two major protein subunits that co-assemble to form gap junctions (GJs) in the cochlea. Mutations in either one of them are the major cause of non-syndromic prelingual deafness in humans. Because the mechanisms
Qing Chang, Wenxue Tang, Shoeb Ahmad, Binfei Zhou, Xi Lin   +4 more
doaj   +1 more source

Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea

Journal of Neuroscience, 2016
Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea.
Tejbeer Kaur, V. Borse, Sandeep Sheth, Kelly Sheehan, Sumana Ghosh, Srinivasan Tupal, S. Jajoo, D. Mukherjea, L. Rybak, V. Ramkumar   +9 more
semanticscholar   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source

Effect of Dielectric Properties of Cochlea on Electrode Insertion Guidance Based on Impedance Variation

Applied Sciences
The cochlear neuromodulator provides substantial auditory perception to those with impaired hearing. The accurate insertion of electrodes into the cochlea is an important factor, as misplaced may lead to further damage.
Enver Salkim
doaj   +1 more source

Localization of the cochlear amplifier in living sensitive ears. [PDF]

PLoS ONE, 2011
To detect soft sounds, the mammalian cochlea increases its sensitivity by amplifying incoming sounds up to one thousand times. Although the cochlear amplifier is thought to be a local cellular process at an area basal to the response peak on the spiral ...
Tianying Ren, Wenxuan He, Edward Porsov
doaj   +1 more source

Neuro-electronic technology in medicine and beyond [PDF]

, 2000
This dissertation looks at the technology and social issues involved with interfacing electronics directly to the human nervous system, in particular the methods for both reading and stimulating nerves.
Ward, Jamie A
core