Results 101 to 110 of about 16,526 (214)

Neutron Crystallography Study of Host–Pathogen Recognition Enhanced by Hydrogen/Deuterium Exchange on Carbohydrates

ChemistryEurope, Volume 4, Issue 3, March 2026.
Neutron macromolecular crystallography enabled by deuteration of biomolecules reveals how the opportunistic pathogen Pseudomonas aeruginosa utilizes calcium‐dependent lectin for binding to human sugars. Neutron diffraction on the complex highlights hydrogen bond network, protonation of amino acids and role of calcium ion.
Theodore Arnaud, Chloé Tatol, Juliette M. Devos, Lukas Gajdos, Sébastien Vidal, Marek Korsak, Annabelle Varrot, Michaela Wimmerova, Sophie Feuillastre, Matthew P. Blakeley, Anne Imberty   +10 more
wiley   +1 more source

Resolution of a Chiral β‐Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular‐Level Insights Into Solution‐Phase Clusters

Chirality, Volume 38, Issue 3, March 2026.
Subtle but significant differences between the heterochiral and homochiral salts during the prenucleation stage, revealed by molecular simulations, are related to the enantiomeric separation of a β‐aminoketone through the precipitation of its corresponding diastereomeric salts. ABSTRACT The classical diastereomeric salt resolution approach was employed
Caterina Momoli, Laura Palombi, Isabella Daidone, Erica Scarel, Massimiliano Aschi   +4 more
wiley   +1 more source

Double Salts and Racemate in Mefloquine–Ibuprofen and Mefloquine–Ketoprofen Systems. A Structural and Thermochemical Analysis

Chirality, Volume 38, Issue 3, March 2026.
(S)‐ibuprofen or ketoprofen were used to resolve mefloquine, forming double salts structurally similar to the racemic forms. ABSTRACT The formation of salts remains a highly sought‐after yet unpredictable strategy for resolving chiral drugs. Using a drug–drug approach, we have investigated the crystallization behavior of Mefloquine (Mf), a racemic ...
Juliana B. Martins, João V. Segatto, Juan C. Tenorio, Paulo S. Carvalho Jr   +3 more
wiley   +1 more source

Investigation of the Storage and Stability as Well as the Dissolution Rate of Novel Ilaprazole/Xylitol Cocrystal

Pharmaceutics
Reflux esophagitis, a treatment for gastric ulcers known as Ilaprazole (Ila), is not stable during storage and handling at room temperature, requiring storage at 5 degrees Celsius. In this study, to address these issues with Ila, coformers rich in oxygen
Sihyun Nam, Changjin Lim, Yongdae Kim, Bokyoung Yoon, Taewoo Park, Woo-Sik Kim, Ji-Hun An   +6 more
doaj   +1 more source

Mechanochemical Synthesis of a Cocrystal of Two Supramolecular Hydrogen-Bonded Aggregates of 1,3,6,8-Tetraazatricyclo[4.3.1.13,8]undecane (TATU) with 4-tert-Butylphenol Bearing Different Hydrogen Bonding Interactions

Crystals, 2018
The synthesis and single crystal structure of a new cocrystal, which is composed of OHphenolic∙∙∙OHphenolic∙∙∙Naminalic supramolecular heterosynthons assembled from 4-tert-butylphenol and the macrocyclic aminal TATU, is presented.
Augusto Rivera, Jicli José Rojas, Jaime Ríos-Motta, Michael Bolte   +3 more
doaj   +1 more source

Chiral Symmetry Breaking in Gelation

Small Structures, Volume 7, Issue 3, March 2026.
Although chiral symmetry breaking in gelation is usually regarded as a rare phenomenon, this might not be true. Rather, recent studies suggest that its probability to emerge in gelation can be higher than that in crystallization, indicating the presence of rich science to be uncovered in the corresponding research fields.
Kentaro Tashiro
wiley   +1 more source

4-Acetylpyridine–fumaric acid (2/1)

Acta Crystallographica Section E, 2009
In the crystal structure of the title cocrystal, 2C7H7NO·C4H4O4, the complete fumaric acid molecule is generated by a crystallographic inversion centre. The two components of the cocrystal are linked by an O—H...N hydrogen bond.
Kan Xu, Bing-Yu Zhang, Jing-Jing Nie, Duan-Jun Xu   +3 more
doaj   +1 more source

Ionic Cocrystals of Etiracetam and Levetiracetam: The Importance of Chirality for Ionic Cocrystals

Crystal Growth & Design, 2019
A striking variety of anhydrous and hydrated ionic cocrystals (ICCs) of the enantiopure antiepileptic drug (AED) levetiracetam and of its racemic intermediate etiracetam with the pharmaceutically acceptable salts CaCl2 and MgCl2 was synthesized and structurally characterized.
Lixing Song, Oleksii Shemchuk, Koen Robeyns, Dario Braga, Fabrizia Grepioni, Tom Leyssens   +5 more
openaire   +3 more sources

Fluorescent proteins: A journey from the cell to extreme environments in material science

Photochemistry and Photobiology, Volume 102, Issue 2, Page 290-302, March/April 2026.
Applications of proteins and microorganisms as tools or effectors in material science. Abstract This review presents the progression from the use of fluorescent proteins (FPs) and chromoproteins as bioimaging labels and sensors to the strategic engineering of their properties for robust functionality in synthetic and non‐biological environments ...
Bianca Menchicchi, Andre C. Stiel, Mattia Nieddu, J. P. Fuenzalida‐Werner   +3 more
wiley   +1 more source

Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley   +1 more source