Results 81 to 90 of about 8,500 (189)
Results in ChemistryIn recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun +7 more
doaj +1 more source
Cocrystals of Fenamic Acids with Nicotinamide
Crystal Growth & Design, 2011 Cocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic acid, tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid–aromatic nitrogen heterosynthon would provide a sufficient driving ...
Fabian, Laszlo +6 more
openaire +3 more sources
Protein Science, Volume 35, Issue 6, June 2026.Abstract The intrinsic dynamic asymmetry between homologous PDZ domains in multidomain scaffold proteins offers insight into how they achieve multivalent partner recognition. Through a systematic x‐ray crystallographic analysis of tandem PDZ1–PDZ2 domains in human syntenin‐1 (SDCBP/MDA‐9), we solved nine high‐resolution structures and uncovered ...
Natsuno Ando +8 more
wiley +1 more source
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.Water activity (aw) was measured in eight DESs (10–90 wt% water). Strong DES–water interactions persist to ∼50 wt%, after which structure collapses toward aqueous‐like behavior. Redlich–Kister, Wilson, and COSMO‐RS models showed limited performance, whereas QSAR modeling using COSMOtherm‐derived σ‐profile descriptors significantly improved aw ...
Marko Rogošić +6 more
wiley +1 more source
Poultry ScienceFatty liver hemorrhagic syndrome (FLHS) severely endangers the health and productivity of laying hens, marked by hepatic steatosis and impaired lipid metabolism. Daidzein-betaine cocrystal improves lipid metabolism in the diet-induced obesity mice.
Yanling Sun +5 more
doaj +1 more source
Crystals, 2017 Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation.
Ji-Hun An +9 more
doaj +1 more source
Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
Research progress of high energy CL-20/HMX cocrystal explosive
Results in ChemistryCocrystal belongs to supramolecular chemistry and it is generally composed of different components including molecules, ions with certain molecular ratio and typical structure.
Guiyun Hang +5 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 12, Page 3601-3620, June 2026.Genetic encoding of noncanonical amino acids (ncAA) enables their site‐specific installation in proteins. This work compares the nuclear magnetic resonance (NMR) performance of different ncAAs in a large protein−DNA complex (~ 100 kDa) without isotope labelling. The ncAAs deliver readily detectable NMR signals in the complex between E.
Sreelakshmi Mekkattu Tharayil +7 more
wiley +1 more source
ChemBioChem, Volume 27, Issue 10, 27 May 2026.We developed fluorescent molecular rotors (FMRs) that respond sensitively to intracellular viscosity. Based on the dye scaffold of GFP, we systematically investigated molecular rigidity and surface area, and discovered FMRs with remarkably high viscosity sensitivity.
Takashi Kanamori +7 more
wiley +1 more source