Results 81 to 90 of about 14,800 (170)

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Daidzein-betaine cocrystal alleviates high-energy and low-protein diet induced fatty liver hemorrhagic syndrome in laying hens through gut-liver axis

Poultry Science
Fatty liver hemorrhagic syndrome (FLHS) severely endangers the health and productivity of laying hens, marked by hepatic steatosis and impaired lipid metabolism. Daidzein-betaine cocrystal improves lipid metabolism in the diet-induced obesity mice.
Yanling Sun, Tiantian Wang, Yu Zhang, Ning Ma, Xinghua Zhao, Xin He   +5 more
doaj   +1 more source

Engineering cocrystal and polymorph architecture via pseudoseeding

, 2009
We use a cocrystal with components arranged in a 1D hydrogen-bonded chain as a pseudoseed to template the components of a cocrystal that otherwise forms a photoactive 0D assembly to form a photostable 1D chain structure.
Friščić, Tomislav; id_orcid, MacGillivray, Leonard R.   +1 more
core   +1 more source

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch- to the Large-Scale Extrusion Processing [PDF]

, 2018
We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents.
Tomislav, Stolar, Irena, Kereković, Stipe, Lukin, Martina, Tireli, Gordana, Matijašić, Krunoslav, Užarević, Ivan, Halasz, Zvonimir, Katančić, Igor, Dejanović, Irena, Sović, Bahar, Karadeniz, Matija, Gretić, Marco, Di Michiel   +12 more
core   +2 more sources

Spectral characterization and vibrational mode study of cocrystal of acetaminophen and aspirin based on terahertz/Raman spectroscopy combined with DFT theory calculation

Results in Chemistry
In recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun, Bo Peng, Xinyi Bai, Bo Su, Cunlin Zhang, Hailin Cui, Shengbo Zhang, Kai Li   +7 more
doaj   +1 more source

–Cubane Cocrystal with Charge Transfer

, 2020
According to the laws of thermodynamics, materials normally exhibit contraction or expansion along the directions of the applied pressure or tension. Here, we show that a man-made cocrystal of a metallofullerene and highly energetic cubane, with strained
Yao, Zhen, Bertil Sundqvist, Éva Kováts, Ying Zhang, Mingguang Yao, Sándor Pekker, Mingrun Du, Liu, Bingbing, Yang, Zhenxing, Wang, Yan, Kovats, Eva, Pekker, Sandor, Zhenxing Yang, Jiajun Dong, Sundqvist, Bertil,, Du, Mingrun, Zhen Yao, Zhang, Ying, Bingbing Liu, Yan Wang, Yao, Mingguang, Dong, Jiajun   +21 more
core   +1 more source

Scientific Coformer Screening, Preparation and Evaluation of Fenofibrate Tartaric Acid Cocrystal [PDF]

, 2019
Objective: This present study aims to screen pharmaceutical cocrystal of Fenofibrate and coformers. Further the preparation and evaluation of  fenofibrate-coformer cocrystal and In-Vitro drug release and Ex-Vivo Permeation study was done.
Pradhan, Sumedh Bandu, Bhalekar, Mangesh
core   +1 more source

Research progress of high energy CL-20/HMX cocrystal explosive

Results in Chemistry
Cocrystal belongs to supramolecular chemistry and it is generally composed of different components including molecules, ions with certain molecular ratio and typical structure.
Guiyun Hang, Jintao Wang, Haijian Xue, Tao Wang, Wenli Yu, Huiming Shen   +5 more
doaj   +1 more source

Structural Characterization of Febuxostat/l-Pyroglutamic Acid Cocrystal Using Solid-State 13C-NMR and Investigational Study of Its Water Solubility

Crystals, 2017
Febuxostat (FB) is a poorly water-soluble drug that belongs to BCS class II. The drug is employed for the treatment of inflammatory disease arthritis urica (gout), and the free base, FB form-A, is most preferred for drug formulation.
Ji-Hun An, Changjin Lim, Hyung Chul Ryu, Jae Sun Kim, Hyuk Min Kim, Alice Nguvoko Kiyonga, Minho Park, Young-Ger Suh, Gyu Hwan Park, Kiwon Jung   +9 more
doaj   +1 more source