Results 71 to 80 of about 14,340 (184)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

PHARMACEUTICAL COCRYSTAL OF PRULIFLOXACIN WITH NICOTINAMIDE [PDF]

, 2014
Objective: Cocrystals have been increasingly recognized as an attractive alternative for solid forms of drug products. In this work nicotinamide (NCT) was employed to form the cocrystal with the active pharmaceutical ingredient prulifloxacin (PF ...
Khanduri, Chandra Has, ALAM, MOHAMMAD SARWAR, RAGHURAM, MORAMPUDI, Prasad, Mohan   +3 more
core   +1 more source

Supramolecular Behaviour of Heterochiral Dipeptides With Ile

Journal of Peptide Science, Volume 32, Issue 10, October 2026.
This study describes the supramolecular behaviour and gelation of heterochiral, aliphatic dipeptides d‐Ile‐l‐Xaa (Xaa = Ala, Val, Leu or Ile) in various solvents and buffered water at neutral pH. Metastable gels rapidly crystallised. X‐ray diffraction analysis was conducted to unveil the dipeptides' packing modes in amphipathic layers.
Erica Scarel, Paola Alletto, Simone Adorinni, Fabio Fazio, Giovanni Pierri, Consiglia Tedesco, Silvia Marchesan   +6 more
wiley   +1 more source

Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

, 2006
The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal ...
Burley, Jonathan C., Motherwell, W. D. Samuel, Friščić, Tomislav, Jones, William, Fabian, Laszlo   +4 more
core   +1 more source

Preparation of Cocrystal Nanofibres of Cobalt Octaethylporphyrin and Tetracyanoquinodimethane with Good Photoresponse

, 2014
Cocrystal nanofibres of cobalt octaethylporphyrin and tetracyanoquinodimethane were prepared by a facile solution method and fully characterized by SEM, AFM, XRD, Raman, EDX, and UV-vis-NIR.
Xiao Y(肖燕), 潘革波, Pan GB(潘革波), Wu HD(吴浩迪), Wang FX(王凤霞)   +4 more
core  

Daidzein-betaine cocrystal alleviates high-energy and low-protein diet induced fatty liver hemorrhagic syndrome in laying hens through gut-liver axis

Poultry Science
Fatty liver hemorrhagic syndrome (FLHS) severely endangers the health and productivity of laying hens, marked by hepatic steatosis and impaired lipid metabolism. Daidzein-betaine cocrystal improves lipid metabolism in the diet-induced obesity mice.
Yanling Sun, Tiantian Wang, Yu Zhang, Ning Ma, Xinghua Zhao, Xin He   +5 more
doaj   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

Spectral characterization and vibrational mode study of cocrystal of acetaminophen and aspirin based on terahertz/Raman spectroscopy combined with DFT theory calculation

Results in Chemistry
In recent years, pharmaceutical cocrystal has become a hot field in drug development, which improves the solubility, stability, and bioavailability of drugs.
Haofei Sun, Bo Peng, Xinyi Bai, Bo Su, Cunlin Zhang, Hailin Cui, Shengbo Zhang, Kai Li   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, Volume 16, Issue 9, Page 1708-1725, September 2026.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Structure determination of the theophylline-nicotinamide cocrystal: a combined powder XRD, 1D solid-state NMR, and theoretical calculation study

, 2014
The crystal structure of a powder pharmaceutical cocrystal, theophylline-nicotinamide (1 : 1) crystal complex, is determined for the first time by using a combination of X-ray powder diffraction (XRPD), 1D solid state NMR, as well as density functional ...
Wenslow, RM (Wenslow, Robert M., Jr.), Yu, KC (Yu, Kaichao), Zhang, HL (张海禄), Chu, YY (Chu, Yueying), Wang, L (Wang, Lin), Li, P (Li, Ping), Deng, ZW (邓宗武)   +6 more
core