Results 61 to 70 of about 14,340 (184)

Crystal engineering optimizes emodin-tetramethylpyrazine combination: From cocrystal design to in vivo anti-colitis efficacy assessment

International Journal of Pharmaceutics: X
Emodin (EMO) shows therapeutic promise for ulcerative colitis (UC), yet its clinical utility is hampered by low bioavailability. To rationally overcome this limitation, this study employed cocrystal engineering, strategically selecting ...
Meiru Liu, Yinru Jiang, Penghui Yuan, Shuang Li, Baoxi Zhang, Xia Zhou, Bin Su, Yifei Xie, Dezhi Yang, Linglei Kong, Li Zhang, Yang Lv, Guanhua Du   +12 more
doaj   +1 more source

Pharmaceutical Cocrystal Formation of Pyrazinamide with 3-Hydroxybenzoic Acid: A Terahertz and Raman Vibrational Spectroscopies Study

Molecules, 2019
Vibrational modes of pyrazinamide (PZA), 3-hydroxybenzoic acid (3-hBA), and their cocrystal were characterized using terahertz time-domain (THz-TDS) and Raman vibrational spectroscopic techniques.
Qiqi Wang, Jiadan Xue, Zhi Hong, Yong Du
doaj   +1 more source

Gas–Solid Interface‐Assisted Growth of Organic Semiconductor Single Crystals: Dimensions, Structures, Mechanisms, and Applications

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Gas–solid interface‐assisted growth strategies have unlocked precise control over crystal structure, morphology, dimension, and molecular packing. The obtained organic semiconductor single crystals represent the ideal candidates for high‐performance organic optoelectronic devices.
Tingyi Yan, Qing Tian, Jinwen Wang, Ke Jiang, Yage Han, Yuanzhuang Ren, Lingyun Li, Xiujuan Zhang, Jiansheng Jie   +8 more
wiley   +1 more source

Synthesis, Updated Characterization, and Reactivity of Low‐Valent Titanocene Complexes

European Journal of Inorganic Chemistry, EarlyView.
Syntheses and characterizations are provided for a series of low‐valent titanocene complexes including halotitanocene(III) dimers, [Cp2Ti(κ2‐DME)][BAr4] cations, and heterobimetallic [Cp2Ti(μ‐Cl)2AlR2]. Additionally, a monomeric titanacyclopropene complex featuring a pendent phosphine was prepared, and C─F bond activation upon reduction of [Cp{η5:κ2F2 ...
Griffin J. LaChapelle, James F. Britten, David J. H. Emslie   +2 more
wiley   +1 more source

Organic neuromorphic optoelectronic sensing materials, intelligent devices, and bionic systems

InfoMat, EarlyView.
Due to the excellent performance and biocompatibility, organic neuromorphic photoelectric sensing technology is regarded as a highly promising research field. In this review, Liu et al. summarize the recent advances in related materials, devices, and system integration.
Yu‐ang Liu, Guocai Liu, Lang Jiang, Yunqi Liu, Yunlong Guo   +4 more
wiley   +1 more source

Mechanochemical Synthesis of Pharmaceutical Cocrystal Suspensions via Hot Melt Extrusion: Enhancing Cocrystal Yield

, 2018
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability.
Tao Yu (176965), Shu Li (136154), Gavin P. Andrews (2890100), Yiwei Tian (2890103), David S. Jones (633681), Colette Lagan (5570714)   +5 more
core   +1 more source

Engineering cocrystal solubility and stability via ionization and micellar solubilization. [PDF]

Pharmaceutical cocrystals have generated enormous interest due to their potential for improving the physicochemical shortcomings of a drug, such as poor aqueous solubility. Poor aqueous solubility can compromise drug performance and cocrystallization is
Huang, Neal Chun
core   +6 more sources

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Hydrogen bonding in cocrystals of trans‐NiII(hfac)2(H2O)2

Acta Crystallographica Section C, EarlyView.
Two cocrystals of trans‐NiII(hfac)2(H2O)2 containing cocrystallized water or 1,2‐dimethoxybenzene were characterized by single‐crystal X‐ray diffraction. The hydrogen‐bonding networks in each cocrystal were compared to previously reported structures, revealing that NiII(hfac)2(H2O)2 is capable of forming a variety of hydrogen‐bond network motifs ...
Grace L. Clemmer, Caden W. York, Mackenzie G. Gray, Elisabeth M. Fatila, Alex Lovstedt   +4 more
wiley   +1 more source

Neutron Vibrational Spectroscopic Study of the Acetonitrile:Acetylene (1:2) Cocrystal Relevant to Titan, Saturn’s Moon [PDF]

Saturn’s moon Titan features a surface composed of various organic solids with pronounced compositional and structural diversity. On top of the icy core, the surface experiences temperature of ~93 K and pressure of ~1.45 atm. Under these conditions, most
Craig , Brown, Rafael, Balderas-Xicohtencatl, Yongqiang, Cheng, Tomce, Runcevski, Morgan , Kramer, Luke, Daemen, Anibal, Ramirez Cuesta   +6 more
core   +1 more source