Results 41 to 50 of about 8,500 (189)

Theoretical study of BTF/TNA cocrystal: Effects of hydrostatic pressure and temperature

Defence Technology, 2015
Cocrystallization is a promising technique for the design and preparation of new explosives, and the stability of cocrystal is highly concerned by the researchers.
Peng-yuan Chen, Lin Zhang, Shun-guan Zhu, Guang-bin Cheng   +3 more
doaj   +1 more source

Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating

Pharmaceuticals, 2023
Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components.
Aytug Kara, Dinesh Kumar, Anne Marie Healy, Aikaterini Lalatsa, Dolores R. Serrano   +4 more
doaj   +1 more source

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Pharmaceutics, 2021
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential.
Sangho Cho, Jeongwook Lee, Yongwon Yoo, Minyong Cho, Seil Sohn, Beom-Jin Lee   +5 more
doaj   +1 more source

Combining a Drug and a Nutraceutical: A New Cocrystal of Praziquantel and Curcumin

Crystals
This study explores the co-crystallization between the drug praziquantel (PZQ) and the nutraceutical curcumin (CU). The investigation revealed two novel solid forms: a cocrystal solvate with ethyl acetate and a non-solvated cocrystal.
Camila Caro Garrido, Marie Vandooren, Koen Robeyns, Damien P. Debecker, Patricia Luis, Tom Leyssens   +5 more
doaj   +1 more source

Cocrystal construction between the ethyl ester with parent drug of diclofenac: structural, stability, and anti-inflammatory study

Heliyon, 2019
This study aimed to collect the crystallographic data of ethyl diclofenac and discover a cocrystal from this ester with its parent, diclofenac acid, and to investigate their physicochemical properties and anti-inflammation activity.
Ilma Nugrahani, Dwi Utami, Yuda Prasetya Nugraha, Hidehiro Uekusa, Rahel Hasianna, Aisyah Amalia Darusman   +5 more
doaj   +1 more source

Pharmaceutical Cocrystals

Procedia Chemistry, 2014
AbstractCocrystals are very interesting and useful product. In this paper the main information about cocrystals is presented. It is shown that cocrystals are solid substances, which consist of few components mixed together. There are a lot of ways of cocrystals production and application.
Korotkova, Elena Ivanovna, Kratochvнl, B.   +1 more
openaire   +2 more sources

Energetic Cocrystals – Structural Studies of Nitrotriazolone Salts & Cocrystals [PDF]

Acta Crystallographica Section A Foundations and Advances, 2014
Developments in energetic materials are currently focused on the requirements for safer, yet still powerful materials for uses within mining, munitions and rocket propulsion systems One strategy that can be used to achieve these desirable properties is to synthesise new molecules, but this is both time-consuming and resource-intensive. Instead, another
Hayleigh Lloyd, Colin Pulham, Paul Coster, Craig Henderson, David Williamson, Andy Jardine   +5 more
openaire   +1 more source

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

Heliyon
In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which
Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du   +7 more
doaj   +1 more source

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

Indonesian Journal of Chemistry, 2019
Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid ...
Yudi Wicaksono, Dwi Setyawan, Siswandono Siswandono, Tri Agus Siswoyo   +3 more
doaj   +1 more source

Decreasing the hygroscopicity of ammonium dinitramide (ADN) through cocrystallization

Energetic Materials Frontiers, 2022
To decrease the hygroscopicity of ADN—a energetic oxidizer, this study developed a new cocrystal composed of ADN and 18C6 (18-crown-6) at a 1:1 ​M ratio through cocrystallization using the solvent evaporation method.
Shen Qiao, Hong-zhen Li, Zong-wei Yang
doaj   +1 more source