Results 41 to 50 of about 14,800 (170)

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Pharmaceutics, 2021
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential.
Sangho Cho, Jeongwook Lee, Yongwon Yoo, Minyong Cho, Seil Sohn, Beom-Jin Lee   +5 more
doaj   +1 more source

Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

, 2006
The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal ...
Burley, Jonathan C., Motherwell, W. D. Samuel, Friščić, Tomislav, Jones, William, Fabian, Laszlo, Friščić, Tomislav; id_orcid, Motherwell, W. D.Samuel   +6 more
core   +1 more source

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

Heliyon
In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which
Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du   +7 more
doaj   +1 more source

Theoretical study of BTF/TNA cocrystal: Effects of hydrostatic pressure and temperature

Defence Technology, 2015
Cocrystallization is a promising technique for the design and preparation of new explosives, and the stability of cocrystal is highly concerned by the researchers.
Peng-yuan Chen, Lin Zhang, Shun-guan Zhu, Guang-bin Cheng   +3 more
doaj   +1 more source

Synthesis and Characterization of a New Norfloxacin/Resorcinol Cocrystal with Enhanced Solubility and Dissolution Profile

Pharmaceutics, 2021
A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael, Rafael Barbas, Rafel Prohens, Clara Ràfols, Elisabet Fuguet   +4 more
doaj   +1 more source

Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids

Pharmaceutics, 2021
The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules.
Ryoma Tanaka, Supisara Osotprasit, Jomjai Peerapattana, Kazuhide Ashizawa, Yusuke Hattori, Makoto Otsuka   +5 more
doaj   +1 more source

Ionic Cocrystal Programming of Spatial Ionic Organization in Carbon Nitrides Enables Highly Efficient H2O2 Photosynthesis

Advanced Materials, EarlyView.
Ionic cocrystal‐programmed ionic organization establishes a general strategy for electrostatic programming in polymeric photocatalysts. ABSTRACT Controlling the spatial organization of ions in polymeric photocatalysts remains a fundamental challenge for optimizing charge transport and catalytic selectivity in solar‐driven hydrogen peroxide (H2O2 ...
Anna Lo Presti, Zahra Hajiahmadi, Sam A. J. Hillman, Mu Xiao, James R. Durrant, Thomas D. Kühne, Christian Mark Pelicano   +6 more
wiley   +1 more source

Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal

, 2022
In this study, we investigated the effects of polymers on the pharmaceutical cocrystal formation process. Ibuprofen (IBU) was selected as the active pharmaceutical ingredient (API), nicotinamide (NIC) and saccharin (SAC) as the cocrystal coformer (CCF ...
Yang Chen (9737), Xintong Yang (4691617), Ning Qiao (1458877)   +2 more
core   +1 more source

Redefining the Minimal Editable Unit of Supramolecular Synthons: A 1→2 Lattice‐Editing Strategy in Ternary Multicomponent Crystals

Advanced Science, EarlyView.
Inspired by skeletal editing, we propose a lattice‐editing strategy that extends the minimal editable unit in supramolecular crystals from individual components to local supramolecular structural units, enabling non‐stoichiometric one‐to‐many substitution while preserving the parent lattice architecture.
Zheng Lin, Honglei Xia, Min Li, Ruihui Wang, Ying Wang, Xiaoyu Feng, Mingjing Tang, Yuan Zhang, Qinghua Zhang   +8 more
wiley   +1 more source

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer

Indonesian Journal of Chemistry, 2019
Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid ...
Yudi Wicaksono, Dwi Setyawan, Siswandono Siswandono, Tri Agus Siswoyo   +3 more
doaj   +1 more source