Results 91 to 100 of about 8,500 (189)

Development of a Lysine‐Reactive Targeted Covalent Inhibitor for the P300/CBP‐Associated Factor Bromodomain Through Structure‐Based Design

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
We developed a targeted covalent inhibitor for the p300/CBP‐associated factor (PCAF) bromodomain. Our lead molecule, 10, labeled a unique lysine residue in the PCAF bromodomain, demonstrated potent inhibition in biophysical/biochemical assays, and engaged the PCAF bromodomain in cells.
Richard R. Ede, Kerstin E. Peterson, Richard K. Begyinah, Irin P. Tom, Jason M. Ochoada, Molly S. Sneddon, Ana Katrina Y. Tiu, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +9 more
wiley   +1 more source

Mechanochemical Synthesis of a Cocrystal of Two Supramolecular Hydrogen-Bonded Aggregates of 1,3,6,8-Tetraazatricyclo[4.3.1.13,8]undecane (TATU) with 4-tert-Butylphenol Bearing Different Hydrogen Bonding Interactions

Crystals, 2018
The synthesis and single crystal structure of a new cocrystal, which is composed of OHphenolic∙∙∙OHphenolic∙∙∙Naminalic supramolecular heterosynthons assembled from 4-tert-butylphenol and the macrocyclic aminal TATU, is presented.
Augusto Rivera, Jicli José Rojas, Jaime Ríos-Motta, Michael Bolte   +3 more
doaj   +1 more source

Investigation of the Storage and Stability as Well as the Dissolution Rate of Novel Ilaprazole/Xylitol Cocrystal

Pharmaceutics
Reflux esophagitis, a treatment for gastric ulcers known as Ilaprazole (Ila), is not stable during storage and handling at room temperature, requiring storage at 5 degrees Celsius. In this study, to address these issues with Ila, coformers rich in oxygen
Sihyun Nam, Changjin Lim, Yongdae Kim, Bokyoung Yoon, Taewoo Park, Woo-Sik Kim, Ji-Hun An   +6 more
doaj   +1 more source

Apremilast Cocrystals with Phenolic Coformers

Molecules
Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates the cocrystallization of APR with four phenolic-type coformers: phenol, catechol, pyrogallol, and hydroxyquinol. These coformers
Yelizaveta Naumkina, Bohumil Kratochvíl, Elena Korotkova, Jan Čejka   +3 more
openaire   +3 more sources

4-Acetylpyridine–fumaric acid (2/1)

Acta Crystallographica Section E, 2009
In the crystal structure of the title cocrystal, 2C7H7NO·C4H4O4, the complete fumaric acid molecule is generated by a crystallographic inversion centre. The two components of the cocrystal are linked by an O—H...N hydrogen bond.
Kan Xu, Bing-Yu Zhang, Jing-Jing Nie, Duan-Jun Xu   +3 more
doaj   +1 more source

Crystal structure, Hirshfeld surface and intermolecular interaction energy analysis of the halogen-bonded 1:1 cocrystal 1-bromo-3,5-dinitrobenzene–N,N-dimethylpyridin-4-amine

Acta Crystallographica Section E: Crystallographic Communications
The structure of the 1:1 cocrystal formed between 1-bromo-3,5-dinitrobenzene and N,N-dimethylpyridin-4-amine that features a C—Br...N halogen bond is reported. The cocrystal, C6H3BrN2O4·C7H10N2, crystalizes in the monoclinic space group P21/c with Z = 4.
Eric Bosch
doaj   +1 more source

Silybin Cocrystals with Improved Solubility and Bioavailability

Pharmaceuticals
Backgroud/Objectives: Silymarin, an extract from milk thistle, is widely recognized for its therapeutic potential in treating liver disorders. However, its clinical utility is limited by the poor solubility and low bioavailability of its key active ...
Bingqing Zhu, Zhenfeng Ding, Xiaoyi Rong, Shengqiang Li, Xuefeng Mei   +4 more
doaj   +1 more source

Energetic cocrystals – structural studies of nitrotriazolone salts and cocrystals [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2013
Hayleigh J. Lloyd, S. Corless, C. R. Pulham   +2 more
openaire   +1 more source

Cocrystal Prediction Based on Deep Forest Model—A Case Study of Febuxostat

Crystals
To aid cocrystal screening, a deep forest-based cocrystal prediction model was developed in this study using data from the Cambridge Structural Database (CSD). The positive samples in the experiment came from the CSD.
Jiahui Chen, Zhihui Li, Yanlei Kang, Zhong Li   +3 more
doaj   +1 more source

Urea Cocrystals as a Potential Fertilizer for Turfgrass: Responses of ‘Tifway’ Hybrid Bermudagrass and Nitrogen Release Behavior

HortTechnology
Urea cocrystal materials are a potential fertilizer source that has shown to decrease environmental nitrogen losses. Novel nitrogen (N)-containing urea cocrystal fertilizers, CaSO4·4urea (UC1) and Ca(H2PO4)2·4urea (UC2), were synthesized using the ...
Reagan W. Hejl, Julia Farias, Jonas Baltrusaitis, Clinton F. Williams, Mohamed Eisa, Dovilė Ragauskaitė, Desalegn D. Serba   +6 more
doaj   +1 more source