Results 101 to 110 of about 14,800 (170)

Silybin Cocrystals with Improved Solubility and Bioavailability

Pharmaceuticals
Backgroud/Objectives: Silymarin, an extract from milk thistle, is widely recognized for its therapeutic potential in treating liver disorders. However, its clinical utility is limited by the poor solubility and low bioavailability of its key active ...
Bingqing Zhu, Zhenfeng Ding, Xiaoyi Rong, Shengqiang Li, Xuefeng Mei   +4 more
doaj   +1 more source

Can picolinamide be a promising cocrystal former?

, 2014
Eight novel cocrystals of picolinamide are reported in this study. Lattice energy calculations may help us to understand their relative stabilities versus those of the individual components. The stoichiometry of one cocrystal changed when heated.
Martin U., Schmidt, Woollam, Grahame, Lewis, Richard, Trixie, Wagner, Chan, Stephen   +4 more
core   +1 more source

Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin–nicotinamide cocrystal by solid-state NMR

, 2012
Two-dimensional 1H double-quantum and 14N–1H & 1H–13C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOHNarom and CHaromOC hydrogen-bonding interactions in the solid-state ...
Iuga, Dinu, Maruyoshi, K., Antzutkin, Oleg N., Velaga, Sitaram,, Maruyoshi, K.,, Iuga, D.,, Alhalaweh, Amjad, Brown, Steven P., Antzutkin, Oleg,, Alhalaweh, Amjad,, Brown, S.P.,, Velaga, Sitaram P.   +11 more
core   +1 more source

Cocrystallization and Particle Size Reduction of Active Pharmaceutical Ingredients (APIs) Using Supercritical Carbon Dioxide Crystallization or Spray Drying

Modern active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility, leading to poor bioavailability. Methods to improve dissolution include altering solid form (salts, polymorphs, cocrystals), creating amorphous dispersions, and ...
MacEachern, Lauren
core  

Impact of the Dissolution Profile of the Cilostazol Cocrystal with Supersaturation on the Oral Bioavailability

, 2017
The objectives of this study are to enhance the oral bioavailability of cilostazol (CLZ), which is a poorly soluble compound, by cocrystallization and to evaluate the correlation between the calculated solubility of the cocrystal by the solubility ...
Tetsuya Ozeki (3628403), Masateru Miyake (3628409), Yusuke Kato (2345269), Masahiko Bando (3014697), Tatsuya Kawato (681216), Motoyasu Yoshimura (3628400), Masafumi Toda (3628406), Toshiro Fukami (1479631)   +7 more
core   +1 more source

Cocrystal Prediction Based on Deep Forest Model—A Case Study of Febuxostat

Crystals
To aid cocrystal screening, a deep forest-based cocrystal prediction model was developed in this study using data from the Cambridge Structural Database (CSD). The positive samples in the experiment came from the CSD.
Jiahui Chen, Zhihui Li, Yanlei Kang, Zhong Li   +3 more
doaj   +1 more source

Organic anion lithium ionic cocrystal compounds and compositions

, 2019
A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates,
Shytle, Roland Douglas, Duggirala, Naga, Zaworotko, Michael John, Smith, Adam John   +3 more
core  

Urea Cocrystals as a Potential Fertilizer for Turfgrass: Responses of ‘Tifway’ Hybrid Bermudagrass and Nitrogen Release Behavior

HortTechnology
Urea cocrystal materials are a potential fertilizer source that has shown to decrease environmental nitrogen losses. Novel nitrogen (N)-containing urea cocrystal fertilizers, CaSO4·4urea (UC1) and Ca(H2PO4)2·4urea (UC2), were synthesized using the ...
Reagan W. Hejl, Julia Farias, Jonas Baltrusaitis, Clinton F. Williams, Mohamed Eisa, Dovilė Ragauskaitė, Desalegn D. Serba   +6 more
doaj   +1 more source

Thermal Behavior of Cocrystal: A Case Study of Ketoprofen-Malonic Acid and Ketoprofen-Nicotinamide Cocrystals

, 2020
Thermal properties are essential parameters in transformations of solid state. It is useful for estimating physicalchemical interactions that occur specifically in a multicomponent system as cocrystal.
WICAKSONO, Yudi, SISWANDONO, Siswandono, SETYAWAN, Dwi, NUGRAHA, Ari Satia   +3 more
core   +1 more source

Crystal Structure Prediction and Intermolecular Interaction Study of CL-20/NQ Cocrystal Explosive

四川大学学报. 自然科学版, 2016
Density functional theory was employed to investigate the four structures (a, b, c, d) of CL-20/NQ cocrystal. The intermolecular interaction, explosive property, and crystal structure were analyzed and predicted in this paper.
GOU Rui-Jun, ZHAO Yuan-Yuan, ZHANG Shu-Hai, DING Xiong, YANG Wen-Sheng, GAO Hong-Fei   +5 more
doaj