Results 121 to 130 of about 23,789 (261)

Modulation of succinyl‐CoA:3‐ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Trypanosomatids are protozoan parasites that remain a global health challenge due to the limited efficacy, safety, and durability of current treatments. Acetate: succinate CoA transferase (ASCT), together with succinyl‐CoA synthase (SCS), forms the ASCT/SCS cycle that fuels ATP production and generates acetate, a central metabolic intermediate
Kota Mochizuki, Daniel Ken Inaoka, Keisuke Fukuda, Hana Kurasawa, Kenji Iyoda, Uta Nakai, Shigeharu Harada, Emmanuel O. Balogun, Frédéric Bringaud, Michael Boshart, Takaya Sakura, Kenji Hirayama, Kiyoshi Kita, Tomoo Shiba   +13 more
wiley   +1 more source

 Pharmaceutical Cocrystals a Patentable Composition - A Review [PDF]

, 2023
Ramadoss Karthikeyan, Haema Ganapathi, Vijayan Venugopal, Sakthiganapathi Meenatchi Sundaram, S Shanmuganathan, V. Velmurugan   +5 more
openalex   +1 more source

Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking [PDF]

, 2018
Extracellular calcium flow through neuronal voltage-gated CaV2.2 calcium channels converts action potential-encoded information to the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, culminating in excitation of the ...
Chen, Xingjuan, Ghozayel, Mona K., Liu, Degang, Meroueh, Samy O., Obukhov, Alexander G., Ripsch, Matthew S., Si, Yubing, Stamatkin, Christopher W., White, Fletcher A., Xu, David, Zhou, Donghui   +10 more
core   +1 more source

Engineering and manufacturing of pharmaceutical co-crystals : a review on solvent-free manufacturing technologies [PDF]

, 2016
Design and synthesis of pharmaceutical cocrystals have received great interest in the recent years. Cocrystallization of drug substances offer a tremendous opportunity for the development of new drug products with superior physical and pharmacological ...
Douroumis, D., Lamprou, D. A., Ross, S. A.   +2 more
core   +1 more source

CARMIL family proteins as multidomain regulators of actin-based motility [PDF]

, 2017
CARMILs are large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper of actin filament barbed ends in cells.
Cooper, John A, Lanier, M. Hunter, Stark, Benjamin C   +2 more
core   +2 more sources

Preliminary assessment on cocrystals of nicotinamide:cinnamic acid and nicotinamide:p-coumaric acid at different solvents and ratio

, 2021
Mohamad Nor Amirul Azhar Kamis, Hamizah Mohd Zaki, Nornizar Anuar, Mohammad Noor Jalil   +3 more
openalex   +2 more sources

Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. [PDF]

, 2020
Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor complex (IL-2Rα/IL-2Rβ/γc).
De Paula, Viviane S, Garcia, K Christopher, Glassman, Caleb R, Jude, Kevin M, Nerli, Santrupti, Sgourakis, Nikolaos G   +5 more
core   +1 more source

Three new hydrochlorothiazide cocrystals: Structural analyses and solubility studies [PDF]

, 2016
YesHydrochlorothiazide (HCT) is a diuretic BCS class IV drug with poor aqueous solubility and low permeability leading to poor oral absorption. The present work explores the cocrystallization technique to enhance the aqueous solubility of HCT.
Aakeröy, Aitipamula, Aitipamula, Aitipamula, Aitipamula, Animesh Ghosh, Bag, Borba, Braga, C. Malla Reddy, Chadha, Chadha, Chadha, Chan, Clarke, Desiraju, Dolomanov, El-Gizawy, Fandaruff, Ghosh, Ghosh, Ghosh, Gonçalves, Gopi, Gwak, Hancock, Kadam, Khan, Krishna, Leuner, Li, Martins, Mureşan-Pop, Ni, Palatinus, Pires, Qiao, Rajewski, Ramesh Devarapalli, Rao Khandavilli, Rasenack, Remenar, Saha, Sanphui, Sanphui, Sarma, Serajuddin, Sheldrick, Subham Ranjan, Sudeshna Kundu, Swapna, Vangala, Vangala, Vasconcelos, Vasisht, Venu R. Vangala, Vyas, Wang   +57 more
core   +1 more source

Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs [PDF]

, 2017
YesPolymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product.
Aitipamula, Aitipamula, Aitipamula, Alhalaweh, Anant Paradkar, Azizi, Bag, Bauer, Benjamin Whiteside, Bernstein, Buanz, Burger, Burger, Cassidy, Chow, Dhumal, Duggirala, Duggirala, Eddleston, Fleischman, Good, Grant, Gu, Hickey, Hilfiker, Hong, Jung, Karki, Li, Maeno, Mangin, McNamara, Niten Jadav, Pagire, Porter, Qiu, Rager, Ranjan, Remenar, Sarkar, Shan, Sheikh, Sudhir K. Pagire, Sun, Trask, Trask, Vangala, Vangala, Vangala, Variankaval, Venu R. Vangala, Vishwehwar   +51 more
core   +1 more source

Searching for Suitable Kojic Acid Coformers: From Cocrystals and Salt to Eutectics

, 2023
Renren Sun, Doris E. Braun, Lucia Casali, Dario Braga, Fabrizia Grepioni   +4 more
openalex   +1 more source