Results 131 to 140 of about 8,547 (185)

On the thermodynamics of cocrystal formation

International Journal of Pharmaceutics, 2009
The thermodynamics underpinning cocrystal formation are derived. The results provide the pharmaceutical scientist with the foundation to experimentally assess the thermodynamic stability of a cocrystal with respect to its component forms. Data for the carbamazepine-nicotinamide system are discussed as an example.
exaly   +3 more sources

Nutraceutical cocrystals: utilizing pterostilbene as a cocrystal former

CrystEngComm, 2010
The nutraceutical compound pterostilbene is investigated for its propensity to form cocrystalline materials with active pharmaceutical ingredients. Three cocrystals of a 1 : 1 stoichiometric molar ratio of pterostilbene with caffeine (two polymorphs, Form I and Form II) and carbamazepine were prepared and characterized by crystallographic (XRPD, single-
Nate Schultheiss, Sarah Bethune, Jan-Olav Henck   +2 more
openaire   +1 more source

Exploring cocrystal–cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

Chem. Commun., 2006
The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal-cocrystal reactions.
Friščić, Tomislav, Fabian, Laszlo, Burley, Jonathan C., Jones, William, Motherwell, W. D. Samuel   +4 more
openaire   +3 more sources

Color-Tunable Upconversion-Emission Switch Based on Cocrystal-to-Cocrystal Transformation

Journal of the American Chemical Society, 2023
Cocrystal engineering, involving the assembly of two or more components into a highly ordered solid-state superstructure, has emerged as a popular strategy for tuning the photophysical properties of crystalline materials. The reversible co-assembly and disassembly of multicomponent cocrystals and their reciprocal transformation in the solid state ...
Yu Wang, Huang Wu, Leighton O. Jones, Martín A. Mosquera, Charlotte L. Stern, George C. Schatz, J. Fraser Stoddart   +6 more
openaire   +2 more sources

Establishment of cocrystal cocktail grinding method for rational screening of pharmaceutical cocrystals

International Journal of Pharmaceutics, 2012
Cocrystals (CCs) used in the pharmaceutical industry are defined as complex crystals formed by reaction between an API and a cocrystal former (CCF); unlike salts, CCs do not show proton transfer. Recently, pharmaceutical CCs have been used to improve the drug-likeness of APIs, such as solubility and stability.
Katsuhiko, Yamamoto, Shunichirou, Tsutsumi, Yukihiro, Ikeda   +2 more
openaire   +2 more sources

Three cocrystals and a cocrystal salt of pyrimidin-2-amine and glutaric acid

Acta Crystallographica Section C Structural Chemistry, 2015
Four new cocrystals of pyrimidin-2-amine and propane-1,3-dicarboxylic (glutaric) acid were crystallized from three different solvents (acetonitrile, methanol and a 50:50 wt% mixture of methanol and chloroform) and their crystal structures determined. Two of the cocrystals, namely pyrimidin-2-amine–glutaric acid (1/1), C4H5N3·C6H8O4, (I) and (II), are ...
Isaac, Odiase, Catherine E, Nicholson, Ruksanna, Ahmad, Jerry, Cooper, Dmitry S, Yufit, Sharon J, Cooper   +5 more
openaire   +2 more sources

COCRYSTAL SOLUBILITY

2017
The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
openaire   +1 more source

PHARMACEUTICAL COCRYSTALS

2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
openaire   +1 more source

Crystal structure and explosive performance of a new CL-20/benzaldehyde cocrystal

Journal of Molecular Structure, 2020
Siping Pang, Chenghui Sun, Teng Fei
exaly  

Deep insight into the charge transfer interactions in 1,2,4,5-tetracyanobenzene-phenazine cocrystal

Chinese Chemical Letters, 2021
Wenping Hu, Xiaotao Zhang, Lingjie Sun   +2 more
exaly