Results 171 to 180 of about 16,526 (214)

Unprecedented Improvement of Near-Infrared Photothermal Conversion Efficiency to 87.2% by Ultrafast Non-radiative Decay of Excited States of Self-Assembly Cocrystal.

Journal of Physical Chemistry Letters, 2021
Near-infrared (NIR) photothermal conversion is of great interest in many fields. Here, a self-assembly organic cocrystal (N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) and pyromellitic dianhydride (PMDA)) with strong absorption in NIR range is ...
Wenbin Chen, Shanshan Sun, Guanheng Huang, Shao‐Fei Ni, Liang Xu, Li Dang, D. Phillips, Ming-de Li   +7 more
semanticscholar   +1 more source

Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges

CrysteEngComm, 2021
This highlight presents an overview of pharmaceutical cocrystal production and its potential in reviving problematic properties of drugs in different dosage forms. The challenges and future outlook of its translational development are discussed.
S. Wong, Yu Chee Sonia Chen, B. Xuan, Changquan Calvin Sun, S. F. Chow   +4 more
semanticscholar   +1 more source

Nutraceutical cocrystals: utilizing pterostilbene as a cocrystal former

CrystEngComm, 2010
The nutraceutical compound pterostilbene is investigated for its propensity to form cocrystalline materials with active pharmaceutical ingredients. Three cocrystals of a 1 : 1 stoichiometric molar ratio of pterostilbene with caffeine (two polymorphs, Form I and Form II) and carbamazepine were prepared and characterized by crystallographic (XRPD, single-
Nate Schultheiss, Sarah Bethune, Jan-Olav Henck   +2 more
openaire   +1 more source

Pharmaceutical cocrystals: An overview

International Journal of Pharmaceutics, 2011
Pharmaceutical cocrystals are emerging as a new class of solid drugs with improved physicochemical properties, which has attracted increased interests from both industrial and academic researchers. In this paper a brief and systematic overview of pharmaceutical cocrystals is provided, with particular focus on cocrystal design strategies, formation ...
Ning, Qiao, Mingzhong, Li, Walkiria, Schlindwein, Nazneen, Malek, Angela, Davies, Gary, Trappitt   +5 more
openaire   +2 more sources

Cocrystal Engineering: A Collaborative Strategy toward Functional Materials

Advances in Materials, 2019
Cocrystal engineering with a noncovalent assembly feature by simple constituent units has inspired great interest and has emerged as an efficient and versatile route to construct functional materials, especially for the fabrication of novel and ...
Lingjie Sun, Yu Wang, Fangxu Yang, Xiaotao Zhang, Wenping Hu   +4 more
semanticscholar   +1 more source

Investigation of Poor Solubility of a Salt-Cocrystal Hydrate: A Case Study of the Common-Ion Effect in Betrixaban, an Anticoagulant Drug.

Molecular Pharmaceutics, 2021
Achieving the desired solubility and dissolution of active pharmaceutical ingredients (APIs) continues to be a big challenge in the pharmaceutical industry. In this regard, multicomponent solids of APIs such as salts and cocrystals have shown significant
R. Devarapalli, Anjaneyaraju Indukuri, Manjunath Bollineni, A. Mondal, C. M. Reddy, Ramanaiah Chennuru   +5 more
semanticscholar   +1 more source

Cocrystal Formation between Chiral Compounds: How Cocrystals Differ from Salts

Crystal Growth & Design, 2014
A cocrystal screening of a series of chiral target compounds was performed in order to investigate the propensity for two optically active compounds to cocrystallize in an enantiospecific manner. Thirteen novel cocrystal systems were identified, out of which 11 are enantiospecific and two present a diastereomeric cocrystal pair, yielding a total of 15 ...
Springuel, Géraldine, Robeyns, Koen, Norberg, Bernadette, Wouters, Johan, Leyssens, Tom   +4 more
openaire   +2 more sources

Stability screening of pharmaceutical cocrystals

Pharmaceutical Development and Technology, 2021
An efficient protocol for assessing both the chemical and physical stability of cocrystalline forms of active pharmaceutical ingredients (APIs) is proposed. In this protocol, the cocrystalline material is used to prepare two standard formulations, mimicking wet granulations, to make low-dose tablets.
Kenneth C, Waterman, Alisa K, Waterman, Teslin M, Botoy, Jane, Li, Fenghe, Qiu, Michael, Hawley   +5 more
openaire   +2 more sources

Novel curcumin ascorbic acid cocrystal for improved solubility

Journal of Drug Delivery Science and Technology, 2020
The present investigation aims to develop novel curcumin-ascorbic acid cocrystal for enhancing the solubility, stability, and complementary biological activities for curcumin. Based on in silico approach to screen ascorbic acid as a coformer for curcumin,
Jidnyasa Pantwalawalkar, H. More, D. Bhange, Udaykumar Patil, N. Jadhav   +4 more
semanticscholar   +1 more source

Cocrystal Engineering: toward Solution-Processed Near-Infrared 2D Organic Cocrystals for Broadband Photodetection.

Angewandte Chemie, 2020
Two-dimensional (2D) cocrystals open a new way to get 2D functional materials via crystal engineering instead of molecular engineering. Here, large-area 2D cocrystals with length reaching several millimeters with strong near-infrared (NIR) absorption ...
Yu Wang, Huan-Bao Wu, Weigang Zhu, Xiaotao Zhang, Zheyuan Liu, Yishi Wu, Changfu Feng, Yanfeng Dang, Huanli Dong, H. Fu, Wenping Hu   +10 more
semanticscholar   +1 more source