Results 161 to 170 of about 8,500 (189)
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Five pseudopolymorphs and a cocrystal of nitrofurantoin
Acta Crystallographica Section C Crystal Structure Communications, 2010The antibiotic nitrofurantoin {systematic name: (E)-1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione} is not only used for the treatment of urinary tract infections, but also illegally applied as an animal food additive. Since derivatives of 2,6-diaminopyridine might serve as artificial receptors for its recognition, we crystallized one ...
Maya, Tutughamiarso +3 more
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Cocrystals and Salts of Gabapentin: pH Dependent Cocrystal Stability and Solubility
Crystal Growth & Design, 2008Thirteen new multicomponent crystals (cocrystals and salts) of an anticonvulsant drug gabapentin with various carboxylic acid coformers have been discovered using the reaction crystallization method (RCM). These new forms are characterized by X-ray powder diffraction (XRPD), Raman and infrared spectroscopy, and differential scanning calorimetry (DSC ...
L. Sreenivas Reddy +3 more
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Chrysin cocrystals: Characterization and evaluation
Journal of Pharmaceutical and Biomedical Analysis, 2017Solvent free mechanochemical approach is utilized to synthesise new cocrystals of chrysin using supramolecular chemistry based upon reliable synthons. Chrysin, a flavone nutraceutical with wide range of beneficial effects has critically low bioavailability on account of its poor aqueous solubility and consequently poor absorption from the ...
Renu, Chadha +4 more
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A melt castable energetic cocrystal
Chemical Communications, 2017Cocrystallization leads to melt-state stabilization of the thermally unstable energetic 4-amino-3,5-dinitropyrazole, allowing for production of a melt castable cocrystalline explosive.
Jonathan C. Bennion +2 more
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Furosemide Cocrystals with Pyridines: An Interesting Case of Color Cocrystal Polymorphism
Crystal Growth & Design, 2015Furosemide (FS), a loop diuretic drug commonly used for the treatment of hypertension and edema, exhibited color cocrystal polymorphism with coformer 4,4′-bipyridine (4BPY) in the stoichiometry 2:1, albeit both the API and the cocrystal former are colorless.
Ekta Sangtani +6 more
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Understanding and Predicting the Effect of Cocrystal Components and pH on Cocrystal Solubility
Crystal Growth & Design, 2009Understanding how cocrystal solubility−pH dependence is affected by cocrystal components is important to engineer cocrystals with customized solubility behavior. Equations that describe cocrystal solubility in terms of solubility product, cocrystal component ionization constants, and solution pH are derived for cocrystals with acidic, basic, amphoteric,
Sarah J. Bethune +3 more
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Advanced methodologies for cocrystal synthesis
Advanced Drug Delivery Reviews, 2017Pharmaceutical cocrystals are multicomponent systems composed of two or more molecules and held together by H-bonding. Currently, cocrystals provide exciting opportunities in the pharmaceutical industry for the development and manufacturing of new medicines by improving poor physical properties of Active Pharmaceutical Ingredients (APIs) such as ...
Dennis Douroumis +2 more
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2017
The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The aim of this project is to improve cocrystal screening and solubility prediction methods.
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The role of cocrystals in pharmaceutical science
Drug Discovery Today, 2008Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ...
Ning, Shan, Michael J, Zaworotko
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2017
The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
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The aim of this project is to improve solubility and dissolution rate of active pharmaceutical ingrednient via cocrystallization.
openaire +1 more source