Results 91 to 100 of about 10,442 (249)

Effect of hydroxyapatite nanoparticles on the degradability of random poly(butylene terephthalate-co-aliphatic dicarboxylate)s having a high content of terephthalic units [PDF]

, 2016
Copolyesters derived from 1,4-butanediol and constituted also of aliphatic and aromatic dicarboxylate units in a molar ratio of 3:7 were synthesized by a two-step polycondensation procedure.
Faramarz Afshar Taromi, Faramarz Afshar, Franco García, María Lourdes, Heidarzadeh, Nina, Mehdi Rafizadeh, Mehdi, Puiggalí Bellalta, Jordi, Valle Mendoza, Luis Javier del   +5 more
core   +2 more sources

Electrospray technique for cocrystallization of phytomolecules

Journal of King Saud University - Science, 2018
Abstract Poor aqueous solubility of most of the phytomolecules has restricted their vital biological use. Cocrystal approach can be one of the remedies for the problem. The present work was carried out with an objective to screen the potential of electrospray technique towards cocrystallization of quercetin (QUE). QUE was cocrystallized with caffeine
Sharvil Patil, Khushbu Chaudhari, Ravindra Kamble   +2 more
openaire   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source

Vibrational Spectroscopy for Cocrystals Screening. A Comparative Study

Molecules, 2018
A recurrent problem faced by the pharmaceutical industry when formulating drug products concerns poorly soluble drugs, which, despite having desirable pharmacological activity, present limited bioavailability.
Marisa Rodrigues, João Lopes, Mafalda Sarraguça   +2 more
doaj   +1 more source

Identification of Quality Markers in Viola kunawaresis Royel Using HPLC Fingerprints, Chemometric Analysis, and Network Pharmacology

Biomedical Chromatography, Volume 40, Issue 4, April 2026.
ABSTRACT Violae tianshanicae herba (VTH), a widely used crude drug in Uyghur medicine in China, is renowned for its immunomodulatory, anti‐inflammatory, antibacterial, antiviral, and antidiabetic activities, with notable efficacy in treating asthma. However, systematic research on its quality markers (Q‐markers) remains limited, underscoring the need ...
Haifeng Liu, Rongmei Zhao, Hong Xu, Tabusi Manaer, Le Pan, Lu Jin, Amatjan Ayupbek   +6 more
wiley   +1 more source

In Silico, In Vitro, and In Vivo Antinociceptive Potential of S‐Naproxen Derivatives

ChemistryOpen, Volume 15, Issue 4, April 2026.
Selected naproxen derivatives were investigated for their antinociceptive effects, using in vitro (COX‐I/COX‐II antagonistic effect), in vivo (acetic acid and hot plate assay), and in silico (molecular simulation studies) approaches. The COX inhibition studies revealed that the maximum percent effect exhibited by GMO‐I‐111a 96.01 and 92% against COX‐2 ...
Ubaidullah, Naveed Muhammad, Abad Khan, Rahaf Ajaj, Abdur Rauf, Umer Rashid, Fahad Hussain, Rashid Khan, Faiza Seraj, Uzma Uzma, Basharat Ali, Abdul Sadiq, Khalid Mohammed Khan, Marcello Iriti   +13 more
wiley   +1 more source

Host–Guest Cocrystallization of Phenanthrene[2]arene Macrocycles Facilitating Structure Determination of Liquid Organic Molecules

Molecules
Single-crystal X-ray diffraction analysis has emerged as the most reliable method for determining the structures of organic molecules. However, numerous analytes, such as liquid organic molecules, pose challenges in crystallization, making their ...
Guangchuan Ou, Yanfeng Zhang, Qiong Wang, Yingzhi Tan, Qiang Zhou, Fei Zeng   +5 more
doaj   +1 more source

The structure of the ternary Eg5–ADP–ispinesib complex [PDF]

, 2012
The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation of monoastral spindles, leading to mitotic arrest that eventually causes apoptosis.
A. W. Schüttelkopf, Adams, Bergnes, Blangy, Britton, Burris, Chen, Cox, Cox, Debonis, Emsley, Esaki, F. Kozielski, Good, Hackney, Harrison, Holen, Kaan, Kabsch, Kapitein, Kim, Kozielski, Lad, Lebedev, Luo, Matsuno, Mayer, Miki, Murshudov, Parrish, S. K. Talapatra, Sakowicz, Schüttelkopf, Sheth, Souid, Turner, Vaguine, Weil, Winn, Wordeman, Yan, Yeates, Zhang   +42 more
core   +2 more sources

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 6, 27 March 2026.
Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen, Monica Cal, Queenie Mondile, Rick Oerlemans, Mukim Mayur Shashikant, Alexander S. S. Dömling, Özlem Tastan Bishop, Pascal Mäser, Matthew R. Groves   +8 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Theoretical Study of Indenoquinolinylphosphine Oxide Derivatives as Topoisomerase 1 Inhibitors and Antiproliferative Agents

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
The topoisomerase I inhibition and antiproliferative activities of phosphorated indenoquinoline derivatives were investigated. The target hybrid quinoline and tetrahydroquinoline compounds were synthesized via a two‐step Povarov‐type cycloaddition.
Alba Rodriguez, Elena Formoso, Birgitta R. Knudsen, Cinzia Tesauro, Maria Fuertes, Concepcion Alonso   +5 more
wiley   +1 more source