Results 131 to 140 of about 61,105 (301)

Antitussive codeine medicines in Ukraine: clinical and pharmacological, marketing, regulatory aspects, and forecasts

Annals of Mechnikov's Institute
Introduction. The circulation and use of codeine-containing medicines require careful regulation to ensure effective treatment of pain and cough and minimize the risks of misuse. In Ukraine, the availability of such medicines is the subject of regulatory
Oleksandr Nevzghoda, Alina Osyntseva, Valentyn Shapovalov, Viktoriia Shapovalova, Oleksandr Veits   +4 more
doaj   +1 more source

Development and Validation of the Brief Inventory of Treatment Expectations in Chronic Pain (BITEC)

European Journal of Pain, Volume 30, Issue 2, February 2026.
ABSTRACT Background Expectations shape therapeutic outcomes, yet their systematic assessment remains limited in clinical and research settings. To address this gap, we developed and validated the Brief Instrument for the Assessment of Treatment Expectations in Chronic Pain (BITEC) using Item Response Theory. Methods The study comprised four phases. (I)
Wolnei Caumo, Bárbara Regina França, Jaira Ehlers, Stela Maris de Jezus Castro, Rogério Boff Borges, Vania Naomi Hirakata, Graziele Borges Bueno, Iraci LS da Torres, Felipe Fregni   +8 more
wiley   +1 more source

A spotlight on the role, use, and availability of codeine and the implications faced

Expert Review of Clinical Pharmacology, 2018
Codeine or 3-methylmorphine, was isolated from poppy seeds in the early 1800’s, soon after the discovery of morphine. It is the most consumed opioid globally based on tonnage [1].
E. Tay, D. Roberts
semanticscholar   +1 more source

Postoperative Prescription Patterns After Sleep Surgery: An International Provider Survey Study

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 1, February 2026.
ABSTRACT Objective To characterize international opioid prescribing patterns among otolaryngologists performing sleep surgery. Methods Cross‐sectional online survey of otolaryngologists and health care professionals who are members of the International Sleep Surgical Society (ISSS).
Amrita N. Bhat, Leyda S. Marrero Morales, Jolie L. Chang, Megan L. Durr   +3 more
wiley   +1 more source

Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme

ACS Omega, 2018
CYP2D6, a cytochrome P450 (CYP) enzyme, metabolizes codeine to morphine. Within the human body, 0–15% of codeine undergoes O-demethylation by CYP2D6 to form morphine, a far stronger analgesic than codeine.
Ibidapo S. Williams, Linda Gatchie, S. Bharate, B. Chaudhuri   +3 more
semanticscholar   +1 more source

The Risk Factors and Mortality Among Patients With Different Combination Patterns of Opioids and Benzodiazepines: A Retrospective Study

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT The concurrent use of opioids and benzodiazepines (BZDs) has raised safety concerns due to increased risks of respiratory depression and death. To evaluate mortality risks linked to different patterns of co‐prescription, we conducted a retrospective cohort study using data from a private hospital system between 2008 and 2018.
Fang‐Yu Su, Ming‐Che Tsai, Yee‐Yung Ng, Shiao‐Chi Wu   +3 more
wiley   +1 more source

Magnetic Dual-template Molecularly Imprinted Polymer Nanoparticles for the Simultaneous Determination of Acetaminophen and Codeine in Urine Samples by Ion Mobility Spectrometry

Analytical Sciences, 2018
Dual-template magnetic molecularly imprinted polymer nanoparticles were synthesized and used for the solid-phase extraction of acetaminophen and codeine before simultaneous determination by corona discharge ion mobility spectrometry.
M. Jafari, B. Rezaei, Hajar Bahrami
semanticscholar   +1 more source

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse ...
Jenny Reeve, Aiden Pang
wiley   +1 more source

Changing trends in drug overdose mortality in Spain, 2001–2022

Addiction, Volume 121, Issue 2, Page 261-272, February 2026.
Abstract Aim To measure the evolution of drug overdose mortality in Spain between 2001 and 2022. Design, Setting, Participants A repeated cross‐sectional observational study using nationwide mortality data from Spain, 2001–2022, among individuals aged 15–64 years.
Florencia Giné, Marta Donat, Juan Miguel Guerras, Gregorio Barrio, María José Belza, Julieta Politi, Enrique Regidor   +6 more
wiley   +1 more source

Prevalence of Opioid Use and Associated Healthcare Outcomes in Rome IV Irritable Bowel Syndrome in the United Kingdom

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 557-568, February 2026.
One in five people with Rome IV irritable bowel syndrome use opioids on a regular basis. Compared with non‐users, opioid users had worse quality of life, greater psychological impairment, and higher direct healthcare costs. ABSTRACT Background The United Kingdom (UK) has one of the highest worldwide opioid prescription rates per capita.
Mohsin F. Butt, Vivek C. Goodoory, Cho Ee Ng, Christopher J. Black, Alexander C. Ford, Maura Corsetti, Peter Paine   +6 more
wiley   +1 more source