Results 81 to 90 of about 186,635 (298)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The law of the sea in the Mediterranean throughout the history / Pravo mora u Sredozemlju tijekom povijesti

open access: yesMiscellanea Hadriatica et Mediterranea, 2017
This paper presents the principal characteristics of the development of the law of the sea in the Mediterranean, from the initial historical sources to the Third UN Conference on the Law of the Sea (1982).
Marina Vokić Žužul, Božena Bulum
doaj   +1 more source

Internal versus External Labour Flexibility : The Role of Knowledge Codification. [PDF]

open access: yes
This article uses a competence-based approach to the firm in order to analyse the recent destabilisation of internal labour markets. We argue that increasing knowledge codification made possible by the diffusion of information and communication ...
Caroli, Eve
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

The Babbage principle after evolutionary economics [PDF]

open access: yes
In this paper we analyse the cognitive roots of the division of labour and relate it to the reduction of tacitness in the organisation and technology of a firm. We study the interaction between efforts of knowledge codification and problems of control in
Hölzl,Werner, Reinstaller,Andreas
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Codification of Islamic Laws: A Critical Study [PDF]

open access: yesHazara Islamicus, 2014
The codification of Islamic Laws is a hot issue among the present Muslim scholars. Some Muslim scholars are of the view that Islamic laws should be codified likewise the western laws; while, on the other hand, some other Muslim scholars are of the ...
Dr Niaz Muhammad, Muhammad Shoaib
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

On the Concept of the New Code of the Russian Federation on Administrative Responsibility: A Brief Commentary on the Bill

open access: yesСибирское юридическое обозрение, 2020
The article comments on the draft Concept of the new Code of the Russian Federation on Administrative Responsibility. It is emphasized that the Concept maintains and develops traditional approaches to the legal regulation of relations that make up the ...
V. E. Sevryugin
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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