Results 171 to 180 of about 199,160 (290)

Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.

, 2019
Translation termination requires eRF1 and eRF3 for polypeptide-and tRNA-release on stop codons. Additionally, Dbp5/DDX19 and Rli1/ABCE1 are required; however, their function in this process is currently unknown.
Beissel , C., Hampe , I., Karki, P., Krebber, H., Neumann, B., Uhse, S.   +5 more
core   +1 more source

Nonsense Codons

Cold Spring Harbor Symposia on Quantitative Biology, 1966
A O, Stretton, S, Kaplan, S, Brenner
openaire   +2 more sources

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ‐aminobutyric acid dysregulation

Epilepsia, EarlyView.
Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon, Claire Bar, Anca Marian, Lisa Lehmann, Solène Renault, Edor Kabashi, Sorana Ciura, Rima Nabbout   +7 more
wiley   +1 more source

Post‐Axial Polydactyly and Postnatal Pulmonary Stenosis Observed With a SPRED1 Pathogenic Variant

Prenatal Diagnosis, EarlyView.
Alexander Gibbs, Muriel Holder‐Espinasse, Vijaya Ramachandran, Natalie J. Chandler   +3 more
wiley   +1 more source

Neocortical neurogenesis: a proneural gene perspective

The FEBS Journal, EarlyView.
The neocortex is a mammalian‐specific brain region responsible for higher‐order cognitive functioning that shares fundamental similarities across species, but which is larger and more complex in humans. Proneural genes, encoding basic helix–loop–helix transcription factors (TFs), are evolutionarily conserved drivers of neurogenesis from fly to human ...
Lakshmy Vasan, Alexandra Moffat, Pierre Mattar, Carol Schuurmans   +3 more
wiley   +1 more source

Potential cytotoxicity of truncated slow skeletal muscle troponin T (ssTnT) in a loss of function TNNT1 myopathy mouse model

The FEBS Journal, EarlyView.
A loss of function TNNT1 myopathy mouse model with the nonsense mutation p.E180* showed potential cytotoxicity of the truncated slow troponin T fragment. The mRNA expression profile in the soleus muscle of Tnnt1‐p.E180* mice showed very different changes in comparison to that of Tnnt1‐knockout mice.
Han‐Zhong Feng, Kevin A. Strauss, Jian‐Ping Jin   +2 more
wiley   +1 more source

Recent advances in improving yield and immunity through transcription factor engineering

Journal of Integrative Plant Biology, EarlyView.
Recent advances have demonstrated that modulating transcription factors can help balance growth and immunity, which is critical to achieving high yield and disease resistance in crops. This review provides a perspective on how specific transcription factors can be engineered to enhance growth and immunity simultaneously. ABSTRACT Transcription factors (
Arya Bagus Boedi Iswanto, Hobin Kang, Seonyeong Park, Geon Hui Son, Sharon M. Pike, Sang Hee Kim   +5 more
wiley   +1 more source

Nonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3

Proceedings of the National Academy of Sciences of the United States of America, 2015
Bijoyita Roy, J. Leszyk, D. A. Mangus, A. Jacobson   +3 more
semanticscholar   +1 more source

D-stem mutation in an essential tRNA increases translation speed at the cost of fidelity.

PLoS Genetics
The efficiency with which aminoacyl-tRNA and GTP-bound translation elongation factor EF-Tu recognizes the A-site codon of the ribosome is dependent on codons and tRNA species present in the polypeptide (P) and exit (E) codon sites.
Madison N Schrock, Krishna Parsawar, Kelly T Hughes, Fabienne F V Chevance   +3 more
doaj   +1 more source

Downregulation of eRF1 by RNA interference increases mis-acylated tRNA suppression efficiency in human cells [PDF]

, 2017
The site-specific incorporation of non-natural amino acids into proteins by nonsense suppression has been widely used to investigate protein structure and function. Usually this technique exhibits low incorporation efficiencies of non-natural amino acids
Ilegems, Erwin, Pick, Horst M., Vogel, Horst   +2 more
core