Results 51 to 60 of about 133,000 (265)

Codon Usage Domains over Bacterial Chromosomes [PDF]

, 2006
The geography of codon bias distributions over prokaryotic genomes and its impact upon chromosomal organization are analyzed. To this aim, we introduce a clustering method based on information theory, specifically designed to cluster genes according to ...
Danchin, Antoine, Vergassola, Massimo, Marc Bailly-Bechet, Marsili, Matteo, Bailly-Bechet, Marc, Antoine Danchin, Mudassar Iqbal, Matteo Marsili, Iqbal, Mudassar; id_orcid, Marsili, Metteo, Massimo Vergassola, Iqbal, Musaddar   +11 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

MicroRNA-mediated repression of nonsense mRNAs

eLife, 2014
Numerous studies have established important roles for microRNAs (miRNAs) in regulating gene expression. Here, we report that miRNAs also serve as a surveillance system to repress the expression of nonsense mRNAs that may produce harmful truncated ...
Ya Zhao, Jimin Lin, Beiying Xu, Sida Hu, Xue Zhang, Ligang Wu   +5 more
doaj   +1 more source

Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons

Advances in Biological Chemistry, 2012
Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon consisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of codon nonsense mutations and suppressor tRNAs in vitro and in vivo.
openaire   +2 more sources

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. [PDF]

, 2008
BACKGROUND: Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression.
Horn, David, Horn, David; id_orcid, Horn David   +2 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons [PDF]

Human Molecular Genetics, 2003
Drug transporters are an important part of the defense of cells against cytotoxic agents. One major group of transporters is known as multidrug resistance associated proteins (MRP; ABCC gene family). The MRPs belong to the ATP binding cassette transporter superfamily. One family member, ABCC4 (also known as MRP4) functions as a cellular efflux pump for
Jatinder Kaur, Lamba, Masashi, Adachi, Daxi, Sun, Jaana, Tammur, Erin G, Schuetz, Rando, Allikmets, John D, Schuetz   +6 more
openaire   +2 more sources

Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential

, 2023
Nonsense-mediated decay (NMD) is a conserved mRNA quality control process that eliminates transcripts bearing a premature termination codon. In addition to its role in removing erroneous transcripts, NMD is involved in post-transcriptional regulation of ...
Steven Batinovic (9481151), MS Bulloch (17473314), CJ Patrick (9877016), SA Ralph (14546957), E McHugh (7957331), DK Sarna (17473317)   +5 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Infrequent Translation of a Nonsense Codon Is Sufficient to Decrease mRNA Level [PDF]

Molecular Biology of the Cell, 1999
In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD). Although previous analyzes have shown that conditions that impede translation termination at nonsense codons also prevent NMD, the residual level of ...
A, Buzina, M J, Shulman
openaire   +2 more sources