Results 131 to 140 of about 1,318 (167)

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1427-1437, November 2026.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Chloroplast Genome Characterization and Phylogenetic Implications of Reyesia and Salpiglossis (Salpiglossideae, Solanaceae)

Ecology and Evolution, Volume 16, Issue 11, November 2026.
We generated and compared the complete chloroplast genomes of Reyesia chilensis and Salpiglossis sinuata, two representative species of the tribe Salpiglossideae (subfamily Cestroideae) within Solanaceae. Comparative plastome analyses revealed highly conserved genome organization, codon usage, and repeat composition, while phylogenetic analyses ...
Jie Huang, Suyun Nong, Yancheng Zhang, Weibin Xu   +3 more
wiley   +1 more source

Broadscale Distribution and Pronounced Mitochondrial Phylogeographic Structure in the Freshwater Minnow Opsariichthys bidens Across China's Major River Basins

Ecology and Evolution, Volume 16, Issue 11, November 2026.
This study investigated mitochondrial genetic diversity and phylogeographic structure in Opsariichthys bidens across China's major river basins using cyt b sequences from 379 individuals and complete mitochondrial genomes from 13 geographic populations. The results revealed limited haplotype sharing, pronounced among‐population differentiation, and two
Xinyue Wang, Denghua Yin, Jie Liu, Ming Yan, Wenwen Li, Silei Liu, Min Jiang, Ning Sun, Kai Liu, Yunzhi Yan   +9 more
wiley   +1 more source

Genotypic‐Phenotypic Correlations in Non‐HbE β‐Thalassemia Intermedia: A Geographic Systematic Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 11, November 2026.
β‐Thalassemia intermedia exhibits distinct region‐specific molecular patterns shaped by three interacting genetic axes: β‐globin mutation severity, HbF‐inducing modifiers, and α‐globin gene dosage. Mediterranean populations are predominantly mutation‐driven, Middle Eastern populations rely on HbF compensation, and Asian populations are governed by ...
Kavindya Fernando, Shiromi Perera, Anuja Premawardhena   +2 more
wiley   +1 more source

Long‐Read Reference Transcriptomes for Five Species of Rosaceae Tribe Spiraeeae: A Resource for Investigating Sequence Divergence, Species‐Associated Expression Variation, and Leaf‐Developmental Candidate Genes

Plant Direct, Volume 10, Issue 11, November 2026.
ABSTRACT Species in the Rosaceae tribe Spiraeeae occupy diverse habitats and vary strikingly in growth form and leaf morphology. Still, no reference transcriptomes have been published for the tribe, and its transcriptome‐level variation is uncharacterized.
Armin M. Mafakheri, Daniel Potter
wiley   +1 more source

MONDE·T: A database and interactive webserver for non‐standard amino acids and peptide components in the PDB

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Non‐standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been explored systematically.
Alex Waldherr, Gesa L. Freimann, Andrei N. Lupas   +2 more
wiley   +1 more source

The Broad Ecological Range of Salmonella enterica Serotype Typhimurium Is Associated With Genomic Diversification

Environmental Microbiology, Volume 28, Issue 11, November 2026.
The broad ecological range of Salmonella enterica serotype Typhimurium is associated with dynamic gain and loss of accessory genes, including plasmid‐associated antimicrobial resistance (AMR) genes, along with positive selection on core genes, potentially contributing to its differential adaptation across food animal and non‐food animal reservoirs ...
Leela Ohri, Sandeep Chinnareddy, Ying‐Xian Goh, Hailong Zhang, Xiangyu Deng, Amy Pruden, Rachel Cheng, Song Li, Jingqiu Liao   +8 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6‐Methyladenosine Modification

Cancer Science, Volume 117, Issue 11, Page 3132-3145, November 2026.
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Zhuoyi Wu, Ruyun Xu, Ju Fang, Bing Liu, Cao Zhang, Shangxin Zhang, Jing Ni   +6 more
wiley   +1 more source