Results 121 to 130 of about 1,318 (167)

Letermovir in Refractory and Resistant CMV After Lung Transplantation: Therapeutic Potential and Emergence of Resistance

Transplant Infectious Disease, EarlyView.
Letermovir use for active R/R CMV infection was associated with treatment‐emergent resistance in approximately one‐third of patients, particularly in those with high baseline viral loads and delayed virological response. These findings support careful patient selection, close virological monitoring, and early resistance testing.
Tobias Veit, Stefan Trost, Teresa Kauke, Nina Engels, Gabriela Leuschner, Michael Gerckens, Carlo Mümmler, Sebastian Michel, Michael Zoller, Valeria Hackemann, Jürgen Behr, Nikolaus Kneidinger   +11 more
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2719-2737, December 2026.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Ocular and Systemic Findings in COL2A1 and COL11A1 Stickler Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 12, Page 2656-2664, December 2026.
ABSTRACT Stickler syndrome is most commonly caused by variants in COL2A1 and COL11A1 genes. The purpose of this study was to describe genetic variants and phenotypes in COL2A1 and COL11A1 Stickler syndrome. We performed a retrospective genotype–phenotype evaluation of COL2A1 and COL11A1 Stickler syndrome subjects. Thirty‐two subjects with COL2A1 and 13
Aileen G. MacLachlan, Jessica A. Kraker, Denise J. Morgan, Lisa A. Schimmenti, M. Elizabeth Hartnett, Eileen S. Hwang   +5 more
wiley   +1 more source

Clinical Laboratory Innovations: Nanoscale Detection of Chloramphenicol Using Nanomaterial Biosensors

Analytical Science Advances, Volume 7, Issue 2, December 2026.
Nanosensor schematic functionalized with specific bioreceptors that produce electrochemical signals upon Chloramphenicol binding. Resulting voltammetric readouts (differential pulse, square‐wave, and cyclic voltammetry) are analyzed to identify and quantify Chloramphenicol.
Nava Moghadasian Niaki, Reza Kheradmand, Seyedeh Giso Akbarian, Elham Shaterian, Hamed Shaterian, Ahmad Mobed   +5 more
wiley   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 12, Page 1949-1964, December 2026.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Insights into the Huanglongbing defense responses in the Australasian citrus species

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Citrus production has declined substantially due to Huanglongbing (HLB), a bacterial disease that has caused severe economic losses worldwide. Long‐term field studies indicate that citrus species differ in their tolerance to HLB, underscoring the importance of incorporating disease‐tolerant traits to sustain the citrus industry.
Jaideep Kaur Deol, Sheetal Ramekar, Frederick G. Gmitter Jr., Jude W. Grosser, Robert Krueger, Manjul Dutt   +5 more
wiley   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV—Important Lessons Learned

Journal of Medical Primatology, Volume 55, Issue 6, December 2026.
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Matthias Tenbusch, Gerrit Koopman, Petra Mooij, Berit Roshani, Pascal Irrgang, Dennis Lapuente, Ivanela Kondova, Willy M. Bogers, Edmond J. Remarque, Ramona Vestweber, Samuel Alberto Merida Ruiz, Nadine Krüger, Sebastian Meyer, Olaf Gefeller, Christiane Stahl‐Hennig, Klaus Überla   +15 more
wiley   +1 more source

Establishing Sensory Neurons as Therapeutic Targets in Peripheral Neuropathy Driven by Polyglutamine Expanded Murine ATXN3

Annals of Neurology, Volume 100, Issue 5, Page 1039-1054, November 2026.
Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato, John M. Hayes, Jacen Emerson, Maeha Sridharan, Toluwani Adelaja, Arsal Naeem, Alexandra F. Putka, Hayley S. McLoughlin   +7 more
wiley   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2378-2389, November 2026.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source