Results 121 to 130 of about 52,855 (250)
Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution. [PDF]
Viruses, 2022 Zhao S, Cui H, Hu Z, Du L, Ran X, Wen X.
europepmc +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective To review the published literature on prenatal findings of COL2A1‐related SEDC, summarizing reported imaging and molecular variants, and to describe two additional prenatal cases evaluated at a tertiary referral center. Method A narrative review with a systematic search strategy was conducted to analyze prenatal imaging findings ...
López‐Rodríguez Larissa +10 more
wiley +1 more source
Codon Bias Can Determine Sorting of a Potassium Channel Protein. [PDF]
Cells, 2021 Engel AJ +7 more
europepmc +1 more source
Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection
PROTEOMICS, EarlyView.ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren +7 more
wiley +1 more source
The effects of codon bias and optimality on mRNA and protein regulation. [PDF]
Cell Mol Life Sci, 2021 Hia F, Takeuchi O.
europepmc +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Climate extremes threaten the sustainability of cranberry production, a culturally and economically important North American crop. This study demonstrates that wild cranberries (Vaccinium oxycoccos) harbor genetic variation that may enhance cold stress resilience when introduced into cultivated cranberry through hybridization.
Audrey Dickinson +5 more
wiley +1 more source
Epx4 Nanopore With Multiple Constrictions for Single‐Molecule Identification
Small Methods, EarlyView.Epx4 is a biological multi‐constriction nanopore that generates informative current signals for polypeptide sensing. Compared with α‐hemolysin, Epx4 detects short poly‐L‐lysine (S‐PLL, Mw 10 kDa) at a higher event frequency and produces signal features that distinguish it from long poly‐L‐lysine (L‐PLL, Mw 30–70 kDa), with an ROC AUC of 0.82 for the ...
Ayako Ijuin +7 more
wiley +1 more source
Codon bias coevolves with longevity
Summary Somatic mutations drive carcinogenesis and aging, shortening the lifespan of animals. Since the vulnerability of genes strongly depends on their size and the abundance of mutation hotspots, we have tested whether negative selection of hypermutable (e.g., CpG bearing) codons could play a role in the evolution of longevity in ...
Krisztina Kerekes +3 more
openaire +1 more source
Comparative Analysis of Genomic and Transcriptome Sequences Reveals Divergent Patterns of Codon Bias in Wheat and Its Ancestor Species. [PDF]
Front Genet, 2021 Yang C +8 more
europepmc +1 more source
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source