Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus [PDF]
BMC Evolutionary Biology, 2010 Abstract Background The influenza A virus is an important infectious cause of morbidity and mortality in humans and was responsible for 3 pandemics in the 20th century. As the replication of the influenza virus is based on its host's machinery, codon usage of its viral genes might be subject to host selection ...
Wong, Emily +4 more
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Analysis of factors shaping synonymous codon usage in pseudorabies virus
浙江大学学报. 农业与生命科学版, 2007 Synonymous codon usage and the main factors shaping codon usage in pseudorabies virus were reported in order to understand the architecture and evolution of pseudorabies virus.
YIN Hua-ping +3 more
doaj +1 more source
Programmed ribosomal frameshifting and codon usage bias [PDF]
, 2018 Experimental evidence shows that synonymous mutations can have important consequences on genetic fitness. Many organisms display codon usage bias (CUB), where synonymous codons that are translated into the same amino acid appear with distinct frequency ...
Anisimova, Maria +2 more
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Developmental Stage and Level of Codon Usage Bias in Drosophila [PDF]
Molecular Biology and Evolution, 2008 Codon usage bias (CUB) is a ubiquitous observation in molecular evolution. As a model, Drosophila has been particularly well-studied and indications show that selection at least partially controls codon usage, probably through selection for translational efficiency.
Vicario S +3 more
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A condition-specific codon optimization approach for improved heterologous gene expression in Saccharomyces cerevisiae [PDF]
, 2014 All authors are with the Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX 78712, USA -- Hal S.
Alper, Hal S. +3 more
core +3 more sources
Enhanced effective codon numbers to understand codon usage bias [PDF]
Biosystems, 2019 Abstract Codon usage bias is a well recognized phenomenon but the relative influence of its major causes: G+C content, mutational biases, and selection, are often difficult to disentangle. This paper presents methods to calculate modified effective codon numbers that allow the investigation of the sources of codon bias and how genes or ...
openaire +2 more sources
On ribosome load, codon bias and protein abundance. [PDF]
PLoS ONE, 2012 Different codons encoding the same amino acid are not used equally in protein-coding sequences. In bacteria, there is a bias towards codons with high translation rates.
Stefan Klumpp, Jiajia Dong, Terence Hwa
doaj +1 more source
Identification of the optimal codons for acetolactate synthase from weeds: an in-silico study
Plant, Soil and Environment, 2021 Although various studies of codon usage bias have been reported in a broad spectrum of organisms, no studies to date have examined codon usage bias for herbicide target genes. In this study, we analysed codon usage patterns for the acetolactate synthase (
Madhab Kumar Sen +3 more
doaj +1 more source
Solving the riddle of codon usage preferences: a test for translational selection [PDF]
, 1998 Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
A Kaminskii +17 more
core +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source