Results 121 to 130 of about 5,587 (151)

SYNTHESIS OF COELENTERAZINE

Organic Preparations and Procedures International, 2001
(2001). SYNTHESIS OF COELENTERAZINE. Organic Preparations and Procedures International: Vol. 33, No. 5, pp. 477-485.
Maciej Adamczyk, Donald D. Johnson, Phillip G. Mattingly, You Pan, Rajarathnam E. Reddy   +4 more
openaire   +1 more source

Concise Synthesis ofv-Coelenterazines

Organic Letters, 2015
A novel synthetic method for v-coelenterazine (v-CTZ), which is a vinylene-bridged analog of native CTZ with a large red-shifted luminescence property, is described. The synthesis was achieved in a concise way through the use of three sequential cross-coupling reactions and ring-closing metathesis (RCM).
Takamitsu, Hosoya, Rie, Iimori, Suguru, Yoshida, Yuto, Sumida, Yuiko, Sahara-Miura, Jun-ichi, Sato, Satoshi, Inouye   +6 more
openaire   +2 more sources

ChemInform Abstract: Synthesis of Coelenterazine.

ChemInform, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Maciej Adamczyk, Donald D. Johnson, Phillip G. Mattingly, You Pan, Rajarathnam E. Reddy   +4 more
openaire   +1 more source

Oxygen Activation of Apo‐obelin–Coelenterazine Complex

ChemBioChem, 2013
AbstractCa2+‐regulated photoproteins use a noncovalently bound 2‐hydroperoxycoelenterazine ligand to emit light in response to Ca2+ binding. To better understand the mechanism of formation of active photoprotein from apoprotein, coelenterazine and molecular oxygen, we investigated the spectral properties of the anaerobic apo‐obelin–coelenterazine ...
Eremeeva, E., Natashin, P.V., Song, L., Zhou, Y., van Berkel, W.J.H., Liu, Z.J., Vysotski, E.S.   +6 more
openaire   +3 more sources

Synthetic Bioluminescent Coelenterazine Derivatives

2016
The development of coelenterazine (CTZ) derivatives resulting in superior optical characteristics is an efficient method to extend the range of its possible applications. Here, we describe the synthesis of three C-6 substituted CTZ derivatives retaining the recognition by Renilla luciferase (RLuc) and its derivatives.
Ryo, Nishihara, Daniel, Citterio, Koji, Suzuki   +2 more
openaire   +2 more sources

Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc

Org. Biomol. Chem., 2017
Synthesis and biological investigation of coelenterazine analogs that demonstrate a tunable red-shift in their bioluminescent emission with NanoLuc luciferase.
Anton Shakhmin, Mary P. Hall, Thomas Machleidt, Joel R. Walker, Keith V. Wood, Thomas A. Kirkland   +5 more
openaire   +2 more sources

Enzymatic activity of albumin shown by coelenterazine chemiluminescence

Luminescence, 2012
ABSTRACTBioluminescence, the emission of light from live organisms, occurs in 18 phyla and is the major communication system in the deep sea. It has appeared independently many times during evolution but its origins remain unknown. Coelenterazine bioluminescence discovered in luminous jellyfish is the most common chemistry causing bioluminescence in ...
N, Vassel, C D, Cox, R, Naseem, V, Morse, R T, Evans, R L, Power, A, Brancale, K T, Wann, A K, Campbell   +8 more
openaire   +2 more sources

Lighting up bioluminescence with coelenterazine: strategies and applications

Photochemical & Photobiological Sciences, 2016
Bioluminescence-based techniques, such as bioluminescence imaging, BRET and dual-luciferase reporter assay systems, have been widely used to examine a myriad of biological processes. Coelenterazine (CTZ), a luciferin or light-producing compound found in bioluminescent organisms, has sparked great curiosity and interest in searching for analogues with ...
Tianyu, Jiang, Lupei, Du, Minyong, Li
openaire   +2 more sources

Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence

Bioconjugate Chemistry, 2020
A synthetic luciferin comprising an imidazopyrazinone core, named HuLumino1, was designed to generate specific bioluminescence with human serum albumin (HSA) in real serum samples. HuLumino1 was developed by attaching a methoxy-terminated alkyl chain to C-6 of coelenterazine and by eliminating a benzyl group at C-8. HSA levels were quantified within 5%
Ryo Nishihara, Kazuki Niwa, Tatsunosuke Tomita, Ryoji Kurita   +3 more
openaire   +2 more sources

Coelenterazine: a two-stage antioxidant in lipid micelles

Free Radical Biology and Medicine, 2004
Coelenterazine is a luciferin found in many marine bioluminescent organisms. This luciferin also possesses high antioxidant properties and an exceptional ability to protect cells exposed to oxidative stress. It has been suggested that coelenterazine's antioxidative mechanisms include the formation of an oxidation product, coelenteramine, also endowed ...
Bertrand, de Wergifosse, Marlène, Dubuisson, Jacqueline, Marchand-Brynaert, André, Trouet, Jean-François, Rees   +4 more
openaire   +2 more sources