Results 71 to 80 of about 9,364,051 (364)

Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity

Nature Communications
Autoantibodies against the enzyme transglutaminase 3 (TG3) are characteristic to the gluten-sensitive skin disorder dermatitis herpetiformis (DH), which is an extraintestinal manifestation of celiac disease.
Rasmus Iversen, Julie Elisabeth Heggelund, Saykat Das, Lene S. Høydahl, Ludvig M. Sollid   +4 more
doaj   +1 more source

Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut

Acta Dermato-Venereologica, 2017
Coeliac disease and dermatitis herpetiformis (DH) are characterized by autoantibodies targeting transglutaminase (TG)2 and TG3, respectively. Previous studies show that TG2 antibodies are produced in the gut and can be assessed in organ culture of small ...
Minna Hietikko, Kaisa Hervonen, Tuire Ilus, Teea Salmi, Heini Huhtala, Kaija Laurila, Tiina Rauhavirta, Timo Reunala, Katri Kaukinen, Katri Lindfors   +9 more
doaj   +1 more source

Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species [PDF]

, 2019
The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet.
Barro Losada, Francisco, Comino Montilla, Isabel María, López Casado, Miguel Ángel, Moreno Amador, María de Lourdes, Ozuna Serafini, Carmen Victoria, Ruiz Carnicer, Ángela, Segura Montero, Verónica, Sousa Martín, Carolina, Torres López, María Isabel   +8 more
core   +1 more source

Gram‐Scale Synthesis of Hafnium‐Rich Carbon Dots for Preclinical Computed Tomography Imaging Across Various Systems

Advanced Science, EarlyView.
Hafnium (Hf)‐rich carbon dots (Hf‐rCDs) with high metal content (40.7%) and robust batch production capacity (>2 g per batch) are synthesized via a facile air‐assisted pyrolysis method. In vivo CT imaging demonstrates outstanding performance of Hf‐rCDs across multiple physiological systems and enables high‐resolution visualization of swine cervical ...
Shuo Li, Hengrui Wu, Jianqi Deng, Qiyu Sun, Yuping Zhang, Cai Zhang, Jinbin Pan, Dingbin Liu, Xuejun Zhang, Quan Zou, Xiaoyuan Chen, Shao‐Kai Sun   +11 more
wiley   +1 more source

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

Cell Reports
Summary: Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients.
Ida Lindeman, Lene S. Høydahl, Asbjørn Christophersen, Louise F. Risnes, Jørgen Jahnsen, Knut E.A. Lundin, Ludvig M. Sollid, Rasmus Iversen   +7 more
doaj   +1 more source

Long-term care for patients with coeliac disease in the UK: a review of the literature and future directions. [PDF]

, 2016
Coeliac disease is a common digestive disorder that affects 1% of adults. It is characterised by mucosal damage of the small intestine caused by dietary gluten.
Bardella, Bebb, Biagi, Biagi, Canavan, Ciacci, Ciacci, Comino, Cooper, Dewar, Fera, Galli, Gray, Haines, Hall, Heel, Holmes, Ilus, Irvine, Kang, Kurppa, Lebwohl, Lee, Leffler, Leffler, Lohi, Lohi, Ludvigsson, Mahadev, Mangione RA, Metzger, Mooney, Moreno, Mulder, Murray, Nazareth, Norstrom, Rubio-Tapia, Rubio-Tapia, Sainsbury, Sainsbury, Sharkey, Silano, Silvester, Tau, Tennyson, Thanvi, West, West   +48 more
core   +1 more source

Elevated serum interleukin‐2 after gluten correlates with symptoms and is a potential diagnostic biomarker for coeliac disease

Alimentary Pharmacology and Therapeutics, 2019
Coeliac disease patients on a gluten‐free diet experience reactions to gluten, but these are not well characterised or understood. Systemic cytokine release was recently linked to reactivation of gluten immunity in coeliac disease.
J. Tye-Din, A. J. Daveson, Hooi C. Ee, G. Goel, J. Macdougall, S. Acaster, K. E. Goldstein, J. Dzuris, Kristin M Neff, Kenneth E. Truitt, Robert P. Anderson   +10 more
semanticscholar   +1 more source

Bakery Products Enriched With Fruit and Vegetable Wastes: A Functional Approach

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Enrichment of bakery products with bioactive compounds from fruit and vegetable wastes. ABSTRACT Bread and other bakery goods are among the most critical components of the human diet, which make them attractive carriers for functional ingredients aimed at improving public health.
Sena Bakir
wiley   +1 more source

Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway [PDF]

, 2012
Objective To determine the ability of selective antibody testing to screen for coeliac disease in the presence of IgA deficiency and to define the sensitivity of a pathway using this method (Figure1).
Arasaradnam, Ramesh P., Harrison, Elizabeth, Liu, Kuo-Kang, Loft, Duncan, Nwokolo, Chuka U., Petchey, Michael   +5 more
core   +1 more source

Learning Curve Effect in Reducing Local Recurrence Rate After Resection of Pancreatic Cancer With Arterial Abutment: A Single‐Center Retrospective Study

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Pancreatectomy for pancreatic ductal adenocarcinoma (PDAC) with arterial abutment is a complex, high‐risk surgery. We aimed to investigate the clinicopathological features, risk factors, and learning curve for local recurrence after pancreatectomy for PDAC with arterial abutment.
Jun Ishida, Hirochika Toyama, Takayuki Kodama, Yoshihide Nanno, Takuya Mizumoto, Shohei Komatsu, Hiroaki Yanagimoto, Masahiro Kido, Tomoo Ito, Takumi Fukumoto   +9 more
wiley   +1 more source