Results 51 to 60 of about 166,204 (247)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10

Neurobiology of Disease, 2005
Neuronal cells depend on mitochondrial oxidative phosphorylation for most of their energy needs and therefore are at a particular risk for oxidative stress.
M. Somayajulu, S. McCarthy, M. Hung, M. Sikorska, H. Borowy-Borowski, S. Pandey   +5 more
doaj   +1 more source

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Coenzyme B induced coordination of coenzyme M via its thiol group to Ni(I) of F-430 in active methyl-coenzyme M reductase

, 2003
Methyl-coenzyme M reductase (MCR) catalyzes the reaction of methyl-coenzyme M (CH3-S-CoM) with coenzyme B (HS-CoB) to methane and CoM-S-S-CoB. At the active site, it contains the nickel porphinoid F430, which has to be in the Ni(I) oxidation state for ...
Thauer, R. ; https://orcid.org/, Finazzo, C., Goenrich, M., Bauer, C., Thauer, RK, Schweiger, A, Jaun, B, Finazzo, C, Duin, E., Jaun, B., Harmer, J, Harmer, J., Van Doorslaer, S., Duin, EC, Goenrich, M, Mahlert, F., Mahlert, F, Bauer, C, Schweiger, A., Van Doorslaer, S, Thauer, R., Jaun B, Bauer C, Finazzo C, Schweiger A, Thauer RK, Van Doorslaer S, Duin EC, Harmer J, Mahlert F, Goenrich M   +30 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Coenzyme B Induced Coordination of Coenzyme M via Its Thiol Group to Ni(I) of F₄₃₀ in Active Methyl-Coenzyme M Reductase

, 2016
Methyl-coenzyme M reductase (MCR) catalyzes the reaction of methyl-coenzyme M (CH3−S−CoM) with coenzyme B (HS−CoB) to methane and CoM−S−S−CoB. At the active site, it contains the nickel porphinoid F430, which has to be in the Ni(I) oxidation state for ...
Evert C. Duin (1623100), Felix Mahlert (2992047), Cinzia Finazzo (2423752), Jeffrey Harmer (1947019), Carsten Bauer (2659198), Meike Goenrich (174838), Rudolf K. Thauer (174856), Arthur Schweiger (2268661), Bernhard Jaun (1901035), Sabine Van Doorslaer (175514)   +9 more
core   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

The Antiviral Potential of a Natural Compound for COVID-19: A Review of the Current Findings

Natural Product Communications
Objective Coronavirus disease 2019 (COVID-19), a novel viral disease originating from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease with dramatic morbidity and mortality globally.
Zahra Jafari-Ardakan, Reza Arefnezhad, Fatemeh Rezaei-Tazangi   +2 more
doaj   +1 more source

The influence of coenzyme Q10 supplementation on antioxidant defense system in the liver of cadmium treated Rats

, 2000
Coenzyme Q10 in its reduced form (CoQ10Hz) is a powerful antioxidant. As an ant io x idant it is exploited either directly upon superoxide or indirectly on lipid radic als.
Štajn, Andraš Š., Žikić, Radoslav V., Ognjanović, Branka, Saičić, Zorica, Petrović, Vojislav M., Pavlović, Slađan   +5 more
core   +1 more source