Results 81 to 90 of about 166,204 (247)
Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials
BMC Cardiovascular Disorders, 2017 Background The therapeutic efficacy of coenzyme Q10 on patients with cardiac failure remains controversial. We pooled previous clinical studies to re-evaluate the efficacy of coenzyme Q10 in patients with cardiac failure.
Li Lei, Yan Liu
doaj +1 more source
Methyl-coenzyme M formation in methanogenic archaea - Involvement of zinc in coenzyme M activation
, 2000 Methyl-coenzyme M (2-methylthioethane sulfonate) is the key intermediate of methane formation in methanogenic archaea. It is generated from coenzyme M (2-mercaptoethane sulfonate) in methyl transfer reactions catalyzed by proteins containing zinc.
Thauer, R. ; https://orcid.org/ +1 more
core +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Advanced Science, EarlyView.A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie +4 more
wiley +1 more source
Acylation of monolysocardiolipin in rat heart
Journal of Lipid Research, 1999 Cardiolipin is a major mitochondrial membrane glycerophospholipid in the mammalian heart. In this study, the ability of the isolated intact rat heart to remodel cardiolipin and the mitochondrial enzyme activities that reacylate monolysocardiolipin to ...
Brian J. Ma +3 more
doaj +1 more source
Protein cost minimization promotes the emergence of coenzyme redundancy
, 2022 Coenzymes distribute a variety of chemical moieties throughout cellular metabolism, participating in group (e.g., phosphate and acyl) and electron transfer. For a variety of reactions requiring acceptors or donors of specific resources, there often exist
Goldford, Joshua E. +7 more
core +1 more source
Engineering an Artificial Metalloenzyme for Efficient Photo‐Enzymatic CO2 Conversion
Advanced Science, EarlyView.We built a light‐driven artificial metalloenzyme by covalently conjugating formate dehydrogenase (FDH) with a tailored rhodium complex (Rh‐L6) to overcome spatial‐separation‐limited electron transfer. This integration boosts NADH regeneration and CO2 conversion, giving 2.31‐fold higher formate yield than physical mixtures, due to a narrowed bandgap and
Mengxue Kang +6 more
wiley +1 more source
Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa
Angewandte Chemie, EarlyView.Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding +3 more
wiley +2 more sources
Advances in Biomarker Sciences and TechnologyBackground: Plasmodium falciparum, the primary causative agent of severe malaria, catabolizes hemoglobin to obtain nutrients, resulting in the accumulation of toxic free heme.
David B. Ouko +7 more
doaj +1 more source
In vitro bioaccessibility of coenzyme Q10 in enriched yoghurts
, 2012 In this study, the aim was to determine the bioaccessibilities of coenzyme Q10 (CoQ10) in yoghurt samples produced using enriched skim milk with different coenzyme Q10 preparations.
El Sedef, Nehir +2 more
core +1 more source