British Journal of Pharmacology, EarlyView.Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley +1 more source
Urgent need for newborn targeted sequencing screening technology in Shandong Province, China. [PDF]
World J PediatrMu JL, Sun M, Li YL, Li PP, Zou H.
europepmc +1 more source
Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors
British Journal of Pharmacology, EarlyView.Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen +3 more
wiley +1 more source
Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy. [PDF]
Antioxidants (Basel)D'Elia M +7 more
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The emergence of metabolisms through Earth history and implications for biospheric evolution. [PDF]
Philos Trans R Soc Lond B Biol SciMoody ERR +6 more
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Pantethine therapy dramatically rescues end-stage failing heart in a patient with deficiency of coenzyme A biosynthesis. [PDF]
ESC Heart FailGoetz V +9 more
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Thiamine, gastrointestinal beriberi and acetylcholine signaling. [PDF]
Front NutrOverton E, Emelyanova A, Bunik VI.
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Acyl-CoA-binding proteins: bridging long-chain acyl-CoA metabolism to gene regulation. [PDF]
New PhytolWundersitz A +2 more
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