Results 271 to 280 of about 254,642 (354)

Metabolic thermodynamics: pertinent reference state and energy potentials

The FEBS Journal, EarlyView.
A recommendation and method to view the energy potentials of metabolites with reference to (green arrow) a biochemical precursor state (in green: water, Mg2+, phosphate, bicarbonate, ammonium, and sulfate, at pH = 7) rather than (the red arrow) the physical–chemical reference state (in grayish red) that is alien to biology, that is, O2, H2, N2 at 1 ...
Hans V. Westerhoff, Barbara M. Bakker, Andreas S. Bommarius, Maria Luz Cárdenas, Athel Cornish‐Bowden, Paul Fitzpatrick, Peter J. Halling, Vassily Hatzimanikatis, Carsten Kettner, Yanhua Liu, Andrew G. McDonald, Elad Noor, Jürgen Pleiss, Frank M. Raushel, Johann M. Rohwer, Santiago Schnell, Keith F. Tipton, Ming‐Daw Tsai, Urs von Stockar, Ulrike Wittig, Roland Wohlgemuth, John M. Woodley   +21 more
wiley   +1 more source

Crystal structure of methanogen MtxX (Methanogen Marker Protein MMP4) from <i>Methanothermobacter thermautotrophicus</i> ΔH. [PDF]

FEMS Microbes
Sutherland-Smith AJ, Carbone V, Kaziur-Cegla W, Woermann M, Schofield LR, Ronimus RS.   +5 more
europepmc   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Successful Living Kidney Donation from Heterozygous Carrier Parents to Siblings with Coenzyme Q8B Nephropathy: Two Case Series. [PDF]

Nephron
Morita K, Nakanishi R, Ogura K, Shinzato T, Matsuo K, Tanaka S, Matsumoto M, Yamamoto S, Kitayama H, Nagano C, Nozu K, Nagai K.   +11 more
europepmc   +1 more source

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

Electron-Mediator-Free Microfluidic Photocatalytic Coenzyme Regeneration with 100% Conversion Efficiency within 126 S. [PDF]

Adv Sci (Weinh)
Chai Y, Wan L, Pang Z, Li X, Jia Z, Jiang H, Tsoi CC, Jia H, Shen J, Zhang Z, Long J, Xie F, Chen Y, Zhang X.   +13 more
europepmc   +1 more source

Additional file 1 of Nitrogen and carbon flows in a microbial mat involving anaerobic oxidation of methane in northwestern Black Sea: perspectives from nitrogen and carbon isotopic composition of coenzyme F430 and its biosynthetic pathway

Kaneko, Masanori, Takano, Yoshinori, Isaji, Yuta, Ogawa, Nanako O., Chikaraishi, Yoshito, Ishikawa, Naoto F., Imachi, Hiroyuki, Takaki, Yoshihiro, Ogawara, Miyuki, Kabashima, Fumie, Krüger, Martin, Ohkouchi, Naohiko   +11 more
openalex   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

Novel Dual-Coenzyme Specificity and Thermostability of Malate Dehydrogenase Identified in the Cyanobacterium <i>Microcystis aeruginosa</i> PCC7806. [PDF]

Int J Mol Sci
Ge Y, Wu Y, Zhou B, Wu X, Ren Y, Zhu J, Ge Y.   +6 more
europepmc   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

The FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito, Yasuyuki Kitaura, Kyoka Iino, Kazuya Toriumi, Hyunah Noh, Naoya Ogawa, Makoto Arai, Hisashi Hemmi, Tomokazu Ito   +8 more
wiley   +1 more source