Results 281 to 290 of about 254,642 (354)

The impact of lipid-rich nutrition on ketogenesis and muscle weakness in sepsis. [PDF]

Intensive Care Med Exp
Lauwers C, Gunst J, El Dawy S, Derde S, Pauwels L, Derese I, Vander Perre S, Van den Berghe G, Casaer MP, Langouche L.   +9 more
europepmc   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Spatial mapping of CoQ10 repletion by BPM31510 in a genetic mouse model (Coq4^F147C) of coenzyme Q deficiency. [PDF]

J Lipid Res
Barriocanal-Casado E, Stopka SA, Pesini A, Aristizabal-Henao JJ, Karmacharya S, Van Cura D, Zhang R, Nickerson KR, Grover K, Zavidij O, Wessel SR, Narain NR, Modur V, Gesta S, Kiebish MA, Quinzii CM.   +15 more
europepmc   +1 more source

The role of impaired de novo Coenzyme A biosynthesis in pantothenate kinase-associated neurodegeneration : insight from a Drosophila model

, 2010
Anil Rana
openalex   +1 more source

Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources

The FEBS Journal, EarlyView.
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani, Marco Gargiulo, Elia Lio, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Maria Assunta Chiacchio, Barış Binay, Stefania Brocca, Francesco Secundo   +8 more
wiley   +1 more source

Bioactive Lipophilic Antioxidants (Carotenoids, Tocols, Retinol, and Coenzyme Q₁₀) in Human and Animal Tissues: Development and Validation of a Rapid Extraction and Chromatographic Method for Nutrition and Health Studies. [PDF]

Antioxidants (Basel)
Benítez-González AM, Stinco CM, Brnčić M, Barba FJ, Meléndez-Martínez AJ.   +4 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Coenzyme Q10 Supplementation in a Child with Biallelic <i>COQ8A</i> Variants: A Case Report. [PDF]

Case Rep Neurol
Motoi H, Watanabe R, Shirai A, Sakata Y, Kuroda Y, Watanabe Y, Ito S.   +6 more
europepmc   +1 more source

Prebiotic aqueous reactions catalyzed by native nickel without hydrogen

The FEBS Journal, EarlyView.
Serpentinizing (H2‐producing) hydrothermal vents are candidate environments for metabolic origin. They generate highly reducing conditions that convert CO2 to formate and methane in abiotic reactions resembling reactions of the acetyl‐CoA pathway of CO2 fixation. They also contain natural catalysts. Native nickel (Ni0), like Fe0, Co0, and their alloys,
Carolina Garcia Garcia, Max Brabender, William F. Martin   +2 more
wiley   +1 more source

A rare case report of familial glucocorticoid deficiency type 4 (GCCD4) with dilated cardiomyopathy: a 3-year follow-up study. [PDF]

Transl Pediatr
Xun Z, Du Y, Zhao T, Wang Z.
europepmc   +1 more source