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Free Radical Biology & Medicine, 2021
Coenzyme Q (CoQ) is a redox active lipid that plays a central in cellular homeostasis. It was discovered more than 60 years ago because of its role as electron transporter in the mitochondrial respiratory chain.
Elisa Baschiera +4 more
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Coenzyme Q (CoQ) is a redox active lipid that plays a central in cellular homeostasis. It was discovered more than 60 years ago because of its role as electron transporter in the mitochondrial respiratory chain.
Elisa Baschiera +4 more
semanticscholar +1 more source
Regulation of Coenzyme Q Biosynthesis Pathway in Eukaryotes.
Free Radical Biology & Medicine, 2021Coenzyme Q (CoQ, ubiquinone/ubiquinol) is a ubiquitous and unique molecule that drives electrons in mitochondrial respiratory chain and an obligatory step for multiple metabolic pathways in aerobic metabolism.
J. M. Villalba, P. Navas
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BioFactors, 2011
AbstractThe key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated.
D James, Morré, Dorothy M, Morré
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AbstractThe key role of coenzyme Q (ubiquinone or Q) is in mitochondrial and prokaryotic energetics. Less well investigated is the basis for its presence in eukaryotic membrane locations other than mitochondria and in plasma where both antioxidant and potentially more targeted roles are indicated.
D James, Morré, Dorothy M, Morré
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Coenzyme Q and Phenylketonuria
Nature, 1964INVESTIGATIONS by Olson's group1,2 of the biosynthesis of coenzyme Q9 (ubiquinone-45) in the rat have shown that phenylalanine is a metabolic precursor of the benzoquinoid ring of coenzyme Q. Presumably, hydroxylation of phenylalanine to yield tyrosine would be an intermediate step in the biosynthesis of coenzyme Q (ref. 3).
E A, NAPIER +3 more
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Russian Chemical Reviews, 1967
CONTENTS I. Discovery and natural sources of ubiquinones 414 II. Determination of the structure of ubiquinones 414 III. Synthesis of ubiquinones 415 IV. Conversion products of ubiquinones 418 V. Biosynthesis of ubiquinones 419 VI. Role of ubiquinones in electron transport in oxidative phosphorylation. Hypotheses concerning the possible mechanism of the
G I Samokhvalov, E A Obol'nikova
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CONTENTS I. Discovery and natural sources of ubiquinones 414 II. Determination of the structure of ubiquinones 414 III. Synthesis of ubiquinones 415 IV. Conversion products of ubiquinones 418 V. Biosynthesis of ubiquinones 419 VI. Role of ubiquinones in electron transport in oxidative phosphorylation. Hypotheses concerning the possible mechanism of the
G I Samokhvalov, E A Obol'nikova
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Coenzyme Q Cytoprotective Mechanisms
2004Publisher Summary This chapter provides an overview of coenzyme Q (CoQ) cytoprotective mechanisms. CoQ cytoprotective mechanisms can be divided into bioenergetic function and antioxidant activity. To discern to what extent these processes are occurring in cells during cell stress, it is necessary to measure the ability of the CoQ hydroquinone to both
Tom S, Chan +2 more
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Regulation of Coenzyme Q biosynthesis
Molecular Aspects of Medicine, 1994The side-chain moiety of coenzyme Q is synthesized by a trans-prenyltransferase present in microsomes. Condensation of this moiety with the precursor ring takes place in the Golgi system. The enzymes involved, as well as the cytosolic geranylgeranyl-PP synthase, are regulated in an independent fashion. When the size of the farnesyl-PP pool is decreased
E L, Appelkvist +4 more
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A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats.
Canadian Journal of Physiology and Pharmacology, 2019Mitochondria are the major source of cellular energy metabolism. In their function they produce a significant amount of free radicals, which in turn affects their function. Imbalance between ROS and antioxidant defense leads to oxidative stress.
A. Gvozdjáková +7 more
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Stimulation of coenzyme Q synthesis
BioFactors, 2008AbstractUptake of dietary coenzyme Q (CoQ) into organs is limited but there are some exceptions such as adrenal glands and ovaries. Under deficient conditions an optimal solution could be stimulation of the endogenous synthesis. In rodent exercise, cold exposure and a few substances elevate the CoQ levels to some extent.
Magnus, Bentinger +5 more
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2000
MOLECULAR MECHANISMS OF COENZYME Q Chemical and Biophysical Properties Biochemical Mechanisms in Electron transport in Mitochondria and Extramitochondrial Locations Antioxidant Mechanisms Prooxidant Mechanisms NUTRITIONAL ASPECTS OF COENZYME Q Biosynthesis and Nutritional Sources Dietary Supplementation and Plasma/Tissue Concentrations HEALTH EFFECT OF
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MOLECULAR MECHANISMS OF COENZYME Q Chemical and Biophysical Properties Biochemical Mechanisms in Electron transport in Mitochondria and Extramitochondrial Locations Antioxidant Mechanisms Prooxidant Mechanisms NUTRITIONAL ASPECTS OF COENZYME Q Biosynthesis and Nutritional Sources Dietary Supplementation and Plasma/Tissue Concentrations HEALTH EFFECT OF
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