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Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations [PDF]

Mitochondrion, 2007
Plasma coenzyme Q10 (CoQ10) response to oral ingestion of various CoQ10 formulations was examined. Both total plasma CoQ10 and net increase over baseline CoQ10 concentrations show a gradual increase with increasing doses of CoQ10. Plasma CoQ10 concentrations plateau at a dose of 2400 mg using one specific chewable tablet formulation.
Raj K. Chopra, Hemmi N. Bhagavan
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Coenzyme Q10 and male infertility

Journal of Endocrinological Investigation, 2009
We had previously demonstrated that Coenzyme Q10 [(CoQ10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility).
Balercia, Giancarlo, Mancini, Antonio, Paggi, F, Tiano, Luca, Pontecorvi, Alfredo, Boscaro, Marco, Lenzi, Andrea, Littarru, Gian Paolo   +7 more
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Coenzyme Q10 in essential hypertension

Molecular Aspects of Medicine, 1994
This study was undertaken to clarify the mechanism of the antihypertensive effect of coenzyme Q10 (CoQ10). Twenty-six patients with essential arterial hypertension were treated with oral CoQ10, 50 mg twice daily for 10 weeks. Plasma CoQ10, serum total and high-density lipoprotein (HDL) cholesterol, and blood pressure were determined in all patients ...
DIGIESI V., CANTINI F., ORADEI A., BISI, Gianni, GUARINO GC, BROCCHI A., BELLANDI F., MANCINI M., LITTARRU GP   +8 more
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Coenzyme Q10 for heart failure

Cochrane Database of Systematic Reviews, 2010
Coenzyme Q10, or ubiquinone, is a non-prescription nutritional supplement. It is a fat-soluble molecule that acts as an electron carrier in mitochondria and as a coenzyme for mitochondrial enzymes. Coenzyme Q10 deficiency may be associated with a multitude of diseases including heart failure.
Yasser Shahrour, Mohammed Eid Madmani, Khalil Tamr Agha, Yasser Madmani, Adib Essali, Waleed Kadro, Ahmad Yusuf Solaiman   +6 more
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Coenzyme Q10 for Parkinson's disease

Cochrane Database of Systematic Reviews, 2011
A number of preclinical studies in both in vitro and in vivo models of Parkinson's disease have demonstrated that coenzyme Q10 can protect the nigrostriatal dopaminergic system. Some clinical trials have looked at the neuroprotective effects of coenzyme Q10 in patients with early and midstage Parkinson's disease.To assess the evidence from randomized ...
Siyan Zhan, Lu-Ning Wang, Jia Liu, Yinyin Xia   +3 more
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Coenzyme Q10 in atherosclerosis

European Journal of Pharmacology
Atherosclerotic disease is a chronic disease that predominantly affects the elderly and is the most common cause of cardiovascular death worldwide. Atherosclerosis is closely related to processes such as abnormal lipid transport and metabolism, impaired endothelial function, inflammation, and oxidative stress. Coenzyme Q10 (CoQ10) is a key component of
Minjun Liao, Xueke He, Yangyang Zhou, Weiqiang Peng, Xiao-Mei Zhao, Miao Jiang   +5 more
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Coenzyme Q10 Deficiency

2014
CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. CoQ10 deficiency has been associated with an enlarging spectrum of phenotypes (Table 56.1). Many patients had cerebellar ataxia, some had recurrent myoglobinuria with ragged-red fibers and lipid storage in muscle, and others had ...
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The Production of Coenzyme Q10 in Microorganisms

2012
Coenzyme Q10 has emerged as a valuable molecule for pharmaceutical and cosmetic applications. Therefore, research into producing and optimizing coenzyme Q10 via microbial fermentation is ongoing. There are two major paths being explored for maximizing production of this molecule to commercially advantageous levels. The first entails using microbes that
Dominic Pinel, Vincent J. J. Martin, Corinne P. Cluis   +2 more
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Coenzyme Q10 in Male Infertility

2016
This chapter deals with the role of coenzyme Q10 in male infertility in the light of the increasing evidence of oxidative damage and antioxidant defence in sperm cells and seminal plasma. Reactive oxygen species have a key pathogenetic role in male infertility as well as a well-recognized physiological function.
Giancarlo Balercia, Antonio Mancini, Giacomo Tirabassi, Alfredo Pontecorvi   +3 more
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Coenzyme Q10 in cardiovascular disease

Mitochondrion, 2007
In this review we summarise the current state of knowledge of the therapeutic efficacy and mechanisms of action of CoQ(10) in cardiovascular disease. Our conclusions are: 1. There is promising evidence of a beneficial effect of CoQ(10) when given alone or in addition to standard therapies in hypertension and in heart failure, but less extensive ...
Silvana Marasco, Silvana Marasco, Silvana Marasco, Franklin L. Rosenfeldt, Franklin L. Rosenfeldt, Franklin L. Rosenfeldt, Henry Krum, Steven Joseph Haas, Salvatore Pepe, Freya L. Sheeran, Freya L. Sheeran   +10 more
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