Results 91 to 100 of about 46,349 (329)
Advanced Science, EarlyView.This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan +7 more
wiley +1 more source
Synthesis and Regulation of Folate Coenzymes During early Germination in Vigna radiata
Pteridines, 2001 Folate profiles and DNA synthesis were studied during the early germinating period in Vigna radiata. Total folate andmethyl folate forms were increased from 4 to 32 hours during germination period studied.
Kesavan V. +3 more
doaj +1 more source
Advanced Science, EarlyView.Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang +9 more
wiley +1 more source
Characterisation of FAD-family folds using a machine learning approach [PDF]
, 2002 Flavin adenine dinucleotide (FAD) and its derivatives play a crucial role in biological processes. They are major organic cofactors and electron carriers in both enzymatic activities and biochemical pathways. We have analysed the relationships between
Gilbert, D, Tan, A C, Tuson, A
core
Gap Detection for Genome-Scale Constraint-Based Models [PDF]
, 2012 Constraint-based metabolic models are currently the most comprehensive system-wide models of cellular metabolism. Several challenges arise when building an in silico constraint-based model of an organism that need to be addressed before flux balance ...
Brooks, J. Paul +4 more
core +3 more sources
Advanced Science, EarlyView.NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota
Advanced Science, EarlyView.This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo +11 more
wiley +1 more source
Frontiers in Immunology, 2017 Activation-induced cytidine deaminase (AID) and its relative APOBEC3 cytidine deaminases boost immune response by mutating immune or viral genes. Because of their genome-mutating activities, AID/APOBECs are also drivers of tumorigenesis.
Mani Larijani, Justin J. King
doaj +1 more source
The RNA world: hypotheses, facts and experimental results. [PDF]
, 2005 A biochemical world that would have existed before the contemporary DNA-RNA-Protein world, and baptized in 1986 "The RNA World" by Walter Gilbert, such a world had already been proposed during the preceding decades by Carl Woese, Francis Crick and Leslie
Haenni, Anne-Lise +1 more
core +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source