Results 91 to 100 of about 86,596 (332)

Identification of New KCNT1‐Epilepsy Drugs by In Silico, Cell, and Drosophila Modeling

Annals of Neurology, EarlyView.
Objective Hyperactive KCNT1 potassium channels, caused by gain‐of‐function mutations, are associated with a range of epilepsy disorders. Patients typically experience drug‐resistant seizures and, in cases with infantile onset, developmental regression can follow.
Michael G. Ricos, Bethan A. Cole, Rashid Hussain, Grigori Y. Rychkov, Zeeshan Shaukat, Nadia Pilati, Stephen P. Muench, Katie J. Simmons, Leanne M. Dibbens, Jonathan D. Lippiat   +9 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Dynamics of Vitamins and Phenols of Alchemilla subcrenata by Diurnal Variation of Temperature in October [PDF]

Journal of Stress Physiology & Biochemistry, 2016
Round-the-clock dynamics of phenols and vitamins В6, С, РР in the leaves of Alchemilla subcrenata with a glance of thermal change was shown. The maximum of content of phenols and vitamin С was observed at 6 a.m.
Zhivetev M.A., Rudikovskaya E.G., Dudareva L.V., Graskova I.A., Voinikov V.K.   +4 more
doaj  

Influence of the Addition of Riboflavin in Culture Medium on Delivering Biomass Using Yeast Strains of Saccharomyces Carlsbengensis

Scientific Papers Animal Science and Biotechnologies, 2023
Yeasts requirements for growth factors should be considered both in terms of ability to summarize the simple average and the dependence on external supplies.
Cornelia Nicoară
doaj  

Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi

Angewandte Chemie, EarlyView.
Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova, Stepan S. Denisov, Thomas Hackl, Kristina Haslinger   +3 more
wiley   +1 more source

ON THE MECHANISM OF DEHYDROGENATION OF FATTY ACYL DERIVATIVES OF COENZYME A

, 1956
F.L. Crane, Helmut Beinert
openalex   +2 more sources

Apoptotic and proliferative processes in the small intestine of rats with type 2 diabetes mellitus after metformin and propionic acid treatment

Frontiers in Pharmacology
BackgroundPropionic acid (PA) is an intermediate product of metabolism of intestinal bacteria and may protect the intestinal barrier from disruption. The aim of the study was to investigate the apoptotic and proliferative processes in the small intestine
Larysa Natrus, Olha Lisakovska, Anton Smirnov, Yuliia Osadchuk, Yuliia Klys   +4 more
doaj   +1 more source

THE NET ENZYMATIC SYNTHESIS OF ACETYL COENZYME A

, 1952
Earl R. Stadtman
openalex   +1 more source

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source