Results 91 to 100 of about 14,411 (293)
Performance evaluation of the UVAPS in measuring biological aerosols: fluorescence spectra from NAD(P)H coenzymes and riboflavin [PDF]
, 2004 This paper presents the results of the performance evaluation of the Ultraviolet Aerodynamic Particle Sizer (UVAPS, model 3312, TSI Inc., St. Paul, MN), the novel instrument for real-time monitoring of biological aerosols. The main objective of the study
Agranovski, Victoria +7 more
core +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser +16 more
wiley +2 more sources
PLoS Computational Biology, 2019 Genome-scale metabolic models (GEMs) are mathematically structured knowledge bases of metabolism that provide phenotypic predictions from genomic information.
Jean-Christophe Lachance +10 more
doaj +1 more source
Ultrasensitive detection of HIV-1 p24 antigen by ELISA coupled with a thio-NAD cycling using alkaline phosphatase, androsterone derivatives, 3α-hydroxysteroid dehydrogenase, and its coenzymes. [PDF]
, 2015 Ultrasensitive detection of HIV-1 p24 antigen by ELISA coupled with a thio-NAD cycling using alkaline phosphatase, androsterone derivatives, 3α-hydroxysteroid dehydrogenase, and its coenzymes.
Mugiho Kaneda (758758) +10 more
core +1 more source
Advanced Science, EarlyView.The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li +4 more
wiley +1 more source
Daurichromenic Acid-producing Oxidocyclase in the Young Leaves of
Natural Product Communications, 2014 Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity. The DCA-producing enzyme, named DCA synthase, could be detected in the soluble protein fraction prepared ...
Futoshi Taura +5 more
doaj +1 more source
The RNA World: Piecing together the historical development of a hypothesis
Mètode Science Studies Journal: Annual Review, 2016 The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta +17 more
wiley +1 more source