Results 141 to 150 of about 99,240 (382)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

open access: yes, 2022
Hepatology, EarlyView.
Robert J. Fontana   +6 more
wiley   +1 more source

Intricate Regulation of Sphingolipid Biosynthesis: An In‐Depth Look Into ORMDL‐Mediated Regulation of Serine Palmitoyltransferase

open access: yesBioEssays, EarlyView.
Multiple enzymes play a crucial role in regulating the biosynthesis of de novo sphingolipids. This regulation starts with the rate‐limiting enzyme, serine palmitoyltransferase (SPT), which catalyzes the first step of the pathway. Disruptions in this regulatory process can lead to serious diseases.
Usha Mahawar, Binks Wattenberg
wiley   +1 more source

Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation

open access: yesBioEssays, EarlyView.
Recently, Singh et al. studied the influence of reactive oxygen species (ROS) formation by the ETC on mitochondrial morphology in baker's yeast. Their findings highlight evolutionary constraints, important trade‐offs using different metabolic substrates, and connections with points of entry into the ETC, ROS production, the FADH2/NADH ratio concept ...
Dave Speijer
wiley   +1 more source

A Setup for Automatic Raman Measurements in High‐Throughput Experimentation

open access: yesBiotechnology and Bioengineering, EarlyView.
Record Raman spectra in High‐Throughput Bioprocess Development. Measure eight samples of 50μL $50\,\mathrm{\mu L}$ fully automated. ABSTRACT High‐throughput (HT) experimentation is transforming biotechnology by enabling systematic exploration of complex multi‐dimensional experimental conditions.
Christoph Lange   +8 more
wiley   +1 more source

The Effects of Surface Disturbances on the Leaching of Heavy Metals [PDF]

open access: yes, 1987
The harmful effects of heavy metal contamination of surface waters impacted by gold mining activity are well documented. An examination was conducted on the effects of surface disturbances in Wade Creek on the concentrations of heavy metals in ...
Brown, Edward J., Dixson, David P.
core  

Efficacy and Engagement With an Immersive Virtual Learning Experience of the Citric Acid Cycle

open access: yesBiochemistry and Molecular Biology Education, EarlyView.
ABSTRACT This randomized controlled trial assessed the comparative effectiveness of a biochemistry education program delivered through an immersive virtual reality (iVR) experience and traditional video‐based instruction. Undergraduate students enrolled in three nutrition courses from a large R1 American university participated (n = 95).
Bianca C. Braga   +9 more
wiley   +1 more source

On the origin and early evolution of biological catalysis and other studies on chemical evolution [PDF]

open access: yes
One of the lines of research in molecular evolution which we have developed for the past three years is related to the experimental and theoretical study of the origin and early evolution of biological catalysis. In an attempt to understand the nature of
Lazcano, A., Oro, J.
core   +1 more source

Oxidation reactions are required to produce atranorin from acetate by alginate-immobilized cells of Cladonia verticillaris. [PDF]

open access: yes, 2000
Atranorin, a p-depside of the b-orcinol series, is produced by several Cladonia species. Immobilized cells of Cladonia verticillaris in calcium alginate are able to produce atranorin when they are supplied with 1.0 mM acetate as a precursor.
Fontaniella, B.   +3 more
core  

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

open access: yesCancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu   +12 more
wiley   +1 more source

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