Results 141 to 150 of about 46,349 (329)
Advanced Science, EarlyView.PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg +3 more
wiley +2 more sources
The interaction of mitochondrial transhydrogenase with derivatives of coenzyme A [PDF]
, 1984 Kozlov Ia +3 more
openalex +1 more source
Advanced Science, EarlyView.Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian +7 more
wiley +1 more source
Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations
Angewandte Chemie, EarlyView.A cysteine‐selective bioconjugation using aromatic cyclopropenium cations is reported. The reaction proceeds rapidly under aqueous conditions, enabling site‐selective installation of tetrasubstituted cyclopropene rings on peptides and proteins. The method shows preference for internal cysteines and provides conjugates that serve as efficient radical ...
Adriana Faraone +6 more
wiley +2 more sources
Advanced Science, EarlyView.This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang +3 more
wiley +1 more source
Carboxylation of acetonyldethio‐coenzyme a by acetyl coenzyme a carboxylase
FEBS Letters, 1978 Nikawa, Jun-ichi +4 more
openaire +2 more sources
Research Progress on Idebenone in Neurodegenerative Diseases
AGING MEDICINE, EarlyView.The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Yanqing Zhang +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.A multicatalytic strategy based on the simple combination of metal‐organic frameworks (MOFs) and organocatalysts is able to mediate challenging aerobic oxidation reactions. The use of earth‐abundant MOFs and commercially available (hydro)quinone co‐catalysts greatly simplify the generation of powerful multicatalytic systems, opening the door for the ...
Juan Camilo Arango‐Daza +5 more
wiley +2 more sources